Bacterial Gene Regulatory Proteins: Organisation and Mechanism of Action
The study of adaptive responses in bacteria led to the discovery of a panoply of proteins whose role is to modulate promoter activity, coupling the expression of specific genes to changes in the environment. These gene regulatory proteins are ubiquitous and are essential for all processes of adaptation and differentiation in all living cells. At first sight, this is a very complex topic, made incomprehensible by the sheer number of different factors and different modes of operation. The aim of this chapter is to tackle the central question of how gene regulatory proteins function, and to describe a small number of key examples from the microbial repertoire that reveal principles applicable to most systems.
KeywordsSingle Amino Acid Substitution Target Promoter Integration Host Factor Gene Regulatory Protein araBAD Promoter
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