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Herpesvirus Evasion of the Immune System

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Antigen Presentation

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 232))

Abstract

It is now well established that animal viruses evade host immunity by many different mechanisms. In an immunocompetent host, the evolutionary pressure brought to bear on viruses is obviously immense, and thus their existence will ultimately dependent upon one form or another of immune subterfuge, subversion, suppression, or abrogation. However, there must also be a well-established balance between the ability of a virus to go around host immunity and the host’s ability to adapt to the virus and ultimately contain it. In the event that this balance is not established, either the host or the virus will be eliminated. It is also important to note that viruses have had a very long time to study the immune system, many millions of years longer than immunologists. Thus, much can be learned by examining the effects of viruses on the immune system and their evasion strategies, not only about the intricate interplay between viruses and the immune system, but also about the workings of the immune system itself.

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  1. L-220, Department of Molecular Microbiology & Immunology, Oregon Health Sciences University, Portland, OR, 97201, USA

    David C. Johnson & Ann B. Hill

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  1. David C. Johnson
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  1. Department of Neuropharmacology, CVN-9, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, CA, 92037, USA

    J. Lindsay Whitton M.D., Ph.D. (Associate Professor) (Associate Professor)

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Johnson, D.C., Hill, A.B. (1998). Herpesvirus Evasion of the Immune System. In: Whitton, J.L. (eds) Antigen Presentation. Current Topics in Microbiology and Immunology, vol 232. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72045-1_8

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