Abstract
The host immune response is generally thought to consist of cells with “professional” immunologic functions, such as B and T cells, macrophages, and natural killer (NK) cells. However, differentiated cells which do not normally participate in immune surveillance may be recruited to serve an integral function in the immune-mediated elimination of foreign intracellular pathogens such as viruses. As discussed elsewhere in this volume, most cells have the ability to present immunogenic, “non-self” peptides (called epitopes) in association with “self&” class I major histocompatibility complex (MHC) molecules. This cell surface complex is engaged by the T cell receptor (TCR) of cytotoxic T lymphocytes (CTL). Appropriate MHC-epitope-TCR interaction leads to the CTL-mediated lysis of the epitope-expressing target cell via the perforation of the plasma membrane, introduction of CTL-derived proteolytic enzymes (granzymes) into the target cell cytosol, and eventual cell death, presumably via apoptosis.
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Keywords
- Major Histocompatibility Complex
- Major Histocompatibility Complex Class
- Central Nervous System Neuron
- Measle Virus Infection
- Major Histocompatibility Complex Expression
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Rall, G.F. (1998). CNS Neurons: The Basis and Benefits of Low Class I Major Histocompatibility Complex Expression. In: Whitton, J.L. (eds) Antigen Presentation. Current Topics in Microbiology and Immunology, vol 232. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72045-1_6
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