Skip to main content
SpringerLink
Log in

Ätiologie und Epidemiologie des Lungenkarzinoms

  • Chapter
Thoraxtumoren

Zusammenfassung

Die mit Abstand häufigste Krebstodesursache in Deutschland ist das Bronchialkarzinom (ICD 162). Im Jahr 1995 starben in der Bundesrepublik Deutschland 37.147 Personen an Lungenkrebs, die meisten davon aufgrund des Rauchens. Bei keiner anderen Tumorform könnten durch wirksame Prävention so viele Todesfälle vermieden werden wie beim Bronchialkarzinom. Das Bronchialkarzinom zog früh das Interesse der Epidemiologen auf sich. Bereits in den 30er Jahren wurden in Deutschland Arbeiten veröffentlicht, die auf einen Zusammenhang zwischen Rauchen und Lungenkrebs hindeuteten (Lickint 1935; Müller 1939), allerdings führten erst große Studien in den 50er Jahren zu einer größeren Akzeptanz dieser Erkenntnis (Wynder u. Graham 1950; Doli u. Hill 1950). Radioaktive Strahlung als Risikofaktor wurde ebenfalls bereits früh entdeckt. Mittlerweile sind eine Reihe von Substanzen bekannt, nach deren Exposition das Lungenkrebsrisiko erhöht ist. Nach gegenwärtiger Kenntnis können über 90% aller Lungenkrebsfälle durch bekannte Risikofaktoren erklärt werden.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 54.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 69.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. Albanes D, Heinonen OP, Taylor PR et al. (1996) Alpha-Tocopherol and beta-carotene supplements and lung cancer incidence in the alpha-tocopherol, beta-carotene cancer prevention study: effects of base-line characteristics and study compliance. J Natl Cancer Inst 88: 1560–1570

    Article  PubMed  CAS  Google Scholar 

  2. Auvinen A, Mäkeläinen I, Hakama M et al. (1996) Indoor radon exposure and risk of lung cancer: a nested case-control study in Finland. J Natl Cancer Inst 88: 966–972

    Article  PubMed  CAS  Google Scholar 

  3. Becher H, Jedrychowski W, Wahrendorf J, Basa-Cierpialek Z, Flak E, Gomola K (1993) Effect of occupational air pollutants on various nistologic types of lung cancer. A population-based case-control study. Br J Indust Med 50: 136–142

    CAS  Google Scholar 

  4. Becher H, Wahrendorf J (1994) Passivrauchen und Lungenkrebsrisiko. Gegenwärtiger epidemiologischer Erkenntnisstand und Abschätzung des Effektes in der Bundesrepublik Deutschland. Dtsch Ärztebl 48, A: 3352–3357

    Google Scholar 

  5. Becher H (1992) Epidemiologie des Bronchialkarzinoms. MMW 134: 569–574

    Google Scholar 

  6. Becker N, Frentzel-Beyme R, Wagner G (1984) Krebsatlas der Bundesrepublik Deutschland. Springer, Berlin Heidelberg New York Tokyo

    Google Scholar 

  7. Becker N, Wahrenaorf J (1997) Krebsatlas der Bundesrepublik Deutschland. 2. Auflage Springer, Berlin Heidelberg New York Tokio

    Google Scholar 

  8. BEIR, IV National Research Council (1988) Health risks of radon and other internally deposited alpha-emitters. National Academy Press, Washington

    Google Scholar 

  9. Brown MM, Caporaso NE, Page WF, Hoover RN (1994) Genetic component of lung cancer: cohort study of twins. Lancet 344: 440–443

    Article  Google Scholar 

  10. Brüske-Hohlfeld I, Wichmann HE, Konietzko N (1995) Lungenkrebs. In: Wichmann H-E, Schlipköter HW, Füllgraff G (Hrsg) Handbuch der Umweltmedizin, 6. erg Lfg, Kap V-1. 3. 4. Ecomed, Lanasberg

    Google Scholar 

  11. Doli R, Hill AB (1950) Smoking and carcinoma of the lung. Preliminary report. Br Med J 111: 739–748

    Article  Google Scholar 

  12. Doll R, Peto R (1991) The causes of cancer: Quantitative estimates of avoidable risks of cancer in the United States today. J Natl Cancer Inst 66: 1191–1308

    Google Scholar 

  13. El-Torky M, El-Zeky F, Hall JC (1990) Significant changes in the distribution of histologic types of lung cancer. Cancer 65: 2361–2367

    Article  PubMed  CAS  Google Scholar 

  14. Enterline PE, Henderson VL, Marsh GM (1987) Exposure to arsenic and respiratory cancer. A reanalysis. Am J Epidemiol 125: 929–38

    PubMed  CAS  Google Scholar 

  15. Environmental Protection Agency (EPA) (1992) Respiratory health effects of passive smoking: lung cancer and other disorders, Office of Research and Development, Office of Health and Environmental Assessment, Washington, D.C., EPA/600/ 6-90-006F

    Google Scholar 

  16. Fontham ETH, Correa P, Reynolds P, Wu-Williams A, Büffler PA, Greenberg RS, Chen VW, Alterman T, Boyd P, Austin DF et al. (1994) Environmental tobacco smoke and lung cancer in nonsmoking women. A multicenter study. JAMA 271: 1752–9

    Article  PubMed  CAS  Google Scholar 

  17. Gilliland FD, Samet JM (1994) Lung cancer. Cancer Surv 19–20: 175–95

    Google Scholar 

  18. Hemminki K, Perhagen G (1992) Cancer risk of air pollution: epidemiological evidence. In: Proceedings Risk assessment of Urban Air. Stockholm

    Google Scholar 

  19. Hoar-Zahm S, Browson RC, Chang JC, Davis JR (1989) Study of lung cancer histologic types, occupation, and smoking in Missouri. Am J Indust Med 15: 565–578

    Article  Google Scholar 

  20. IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans (1986) Tobacco smoking, vol 38. International Agency for Research on Cancer, Lyon, France

    Google Scholar 

  21. IARC Monographs on the Evaluation of Carcinogenic Risks of Chemicals to Humans (1990) Chromium, nickel and welding, vol 49. International Agency for Research on Cancer, Lyon, France

    Google Scholar 

  22. Jedrychowski W, Becher H, Wahrendorf J, Basa-Cierpialek Z (1990) A case-control study of lung cancer with special reference to the effect of air pollution in Poland. J Epid Comm Health 44: 114–120

    Article  CAS  Google Scholar 

  23. Jedrychowski W, Becher H, Wahrendorf J, Basa-Cierpialek Z, Gomola G (1992) Effect of tobacco smoking on various histologic types of lung cancer. J Cancer Res Clin Oncol 118: 276–282

    Article  PubMed  CAS  Google Scholar 

  24. Jockel KH, Ahrens W, Jahn I, Pohlabeln H, Bolm-Audorff U (1995) Untersuchungen zu Lungenkrebs und Risiken am Arbeitsplatz. Schriftenreihe der Bundesanstalt für Arbeitsmedizin. Wirtschaftsverlag, Bremerhaven

    Google Scholar 

  25. Jockel K-H, Ahrens W, Wichmann H-E, Becher H, Bolm-Audorff U, Jahn I, Molik B, Greiser E, Timm J (1992) Occupational and environmental hazards associated with lung cancer. Int J Epidemiol 21: 202–213

    Article  PubMed  CAS  Google Scholar 

  26. Länderausschuß für Imissionsschutz (1992) Beurteilungsmaßstäbe zur Begrenzung des Krebsrisikos durch Luftverunreinigungen. Ministerium für Umwelt, Raumordnung und Landwirtschaft des Landes NW (Hrsg), S 1–158

    Google Scholar 

  27. Le Marchand L, Yoshizawa CN, Kolonel LN, Hankin JH, Goodman MT (1989) Vegetable consumption and lung cancer risk: a population-based case-control study in Hawaii. JNCI 81: 1158–64

    PubMed  Google Scholar 

  28. Lickint F (1935) Der Bronchialkrebs der Raucher. MMW 82: 1158–1164

    Google Scholar 

  29. Lubin JH, Blot WJ (1984) Assessment of lung cancer risk factors by histologic category. JNCI 73: 383–389

    PubMed  CAS  Google Scholar 

  30. Lubin JH, Boice JD, Edling C, Hornung RW, Howe G, Kunz E, Kusiak A, Morrison HI, Radford EP, Samet JM, Tirmarche M, Woodward A, Xiang YS, Pierce DA (1994a) Radon and lung cancer risk: A joint analysis of 11 underground miners studies. National Institutes of Health, NIH Publ 94: 3644

    Google Scholar 

  31. Lubin JH, Zhonghua L, Hrubec Z, Pershagen G, Schoenberg JB, Blot WJ, Klotz JB, Xu Z-Y, Boice JD Jr. (1994b) Radon exposure in residences and lung cancer among women: combined analysis of three studies. Cancer Causes Control 5: 114–128

    Article  PubMed  CAS  Google Scholar 

  32. Müller FH (1939) Tabakmißbrauch und Lungenkrebs. Z Krebsforsch 49: 57–85

    Google Scholar 

  33. Nakachi K et al. (1991) Genetic susceptibility to squamous cell carcinoma of the lung in relation to cigarette smoking dose. Cancer Res 51: 5177–5180

    PubMed  CAS  Google Scholar 

  34. Negri E, La Vecchia C (1995) Epidemiology of lung cancer: recent trends in mortality with emphasis on Europe. Lung Cancer 12: S3–11

    Article  Google Scholar 

  35. Omenn GS, Goodman GE, Thornquist MD, Balmes J, Cullen MR, Glass A, Keogh JP, Meyskens FL Jr, Valanis B, Williams JH Jr, Barnhart S, Cherniack MG, Brodkin CA, Hamar S (1996) Risk factors for lung cancer and for intervention effects in CARET, the beta-carotene and retinol efficacy trial. J Natl Cancer Inst 88: 1550–9

    Article  PubMed  CAS  Google Scholar 

  36. Perng DW, Perng RP, Kuo BI, Chiang SC (1996) The variation of cell type distribu¬tion in lung cancer: a study of 10,910 cases at a medical center in Taiwan between 1970 and 1993. Jpn J Clin Oncol 26: 229–33

    PubMed  CAS  Google Scholar 

  37. Pershagen G, Simonato L (1990) Epidemiological evidence on air pollution and cancer. In: Tomatis L (ed) Air pollution and human cancer. Springer, Berlin Heidelberg New York

    Google Scholar 

  38. Pershagen G, Äkerblom G, Axelson O, Clavensjö B, Damber L, Desai G, Enflo A, Lagarde F, Mellander H, Svartengren M, Swedjemark GA (1994) Residential radon exposure and lung cancer in Sweden. N Engl J Med 330: 159–64

    Article  PubMed  CAS  Google Scholar 

  39. Saracci R, Riboli E (1989) Passive smoking and lung cancer: current evidence and ongoing studies at the International Agency for Research on Cancer. Mutat Res 222: 117–127

    Article  PubMed  CAS  Google Scholar 

  40. Schottenfeld D u. Fraumeni JF Jr (eds) (1996) Cancer epidemiology and prevention, 2nd edn. Oxford Univ Press, New York Oxford

    Google Scholar 

  41. Schwartz AG, Yang P, Swanson GM (1996) Familial risk of lung cancer among non- smokers and their relatives. Am J Epidemiol 144: 554–62

    PubMed  CAS  Google Scholar 

  42. Shaw GL et al. (1991) Lung cancer risk associated with cancer in relatives. J Clin Epidemiol 44: 429–437

    Article  PubMed  CAS  Google Scholar 

  43. Simonato L, Vineis P, Fletcher AC (1988) Estimates of the proportion of lung cancer attributable to occupational exposure. Carcinogenesis 9: 1159–1165

    Article  PubMed  CAS  Google Scholar 

  44. Statistisches Landesamt Saarland (Hrsg.) (1996) Morbidität und Mortalität an bösartigen Neubildungen im Saarland 1993. Eigenverlag, Saarbrücken

    Google Scholar 

  45. Steenland K, Loomis D, Shy C, Simonsen N (1996) Review of occupational lung carcinogens. Am J Ind Med 29: 474–90

    Article  PubMed  CAS  Google Scholar 

  46. Steindorf K, Lubin, J, Wichmann H-E, Becher H (1995) Lung cancer deaths attributable to indoor radon exposure in West Germany. Int J Epidemiol 24

    Google Scholar 

  47. Steinmetz KA, Potter JD (1991) Vegetables, fruit, and cancer. I. Epidemiology. Cancer Causes Control 2: 325–357

    Article  PubMed  CAS  Google Scholar 

  48. Stockwell HG, Goldman AL, Noss CI, Armstrong AW, Pinkham PA, Candelora EC, Brusa MR (1992) Environmental tobacco smoke and lung cancer risk in non-smoking women. J Natl Cancer Inst 84: 1417–1422

    Article  PubMed  CAS  Google Scholar 

  49. Vena JE (1982) Air pollution as a risk factor in lung cancer. Am J Epidemiol 116: 42–56

    PubMed  CAS  Google Scholar 

  50. Wichmann HE, Kreienbrock L, Kreuzer M, Goetze HJ, Heinrich J, Gerken M (1993) Radon und Lungenkrebs — Kenntnisstand und erste Erfahrungen mit einer Studie in der Bundesrepublik Deutschland. In: Veröffentlichungen der Strahlenschutzkom-mission. Fischer, Stuttgart

    Google Scholar 

  51. Wu AH, Fontham ET, Reynolds P, Greenberg RS, Büffler P, Liff J, Boyd P, Correa P (1996) Family history of cancer and risk of lung cancer among lifetime nonsmoking women in the United States. Am J Epidemiol 143: 535–42

    PubMed  CAS  Google Scholar 

  52. Wynder EL, Graham EA (1950) Tobacco smoking as a possible etiologic factor in bronchiogenic carcinoma. A study of six hundred and eighty-four proved cases. J Am Med Assoc 143: 239–336

    Article  Google Scholar 

  53. Wynder EL, Hebert JR, Kabat GC (1987) Association of dietary fat and lung cancer. JNCI 79: 631–637

    PubMed  CAS  Google Scholar 

  54. Xu Z-Y, Blot WJ, Xiao H-P, Wu A, Feng Y-P, Stone BJ, Sun J, Ershow AG, Henderson BE, Fraumeni Jr JF (1989) Smoking, air pollution, and the high rates of lung cancer in Shengyang, China. J Natl Cancer Inst 81: 1800–1806

    Article  PubMed  CAS  Google Scholar 

  55. Ziegler RG, Mayne ST, Swanson CA (1996) Nutrition and lung cancer. Cancer Causes Control 7: 157–177

    Article  PubMed  CAS  Google Scholar 

Download references

Authors
  1. H. Becher
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J. Wahrendorf
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Abteilung Innere Medizin/Onkologie, Thoraxklinik Heidelberg-Rohrbach der Landesversicherungsanstalt Baden, Amalienstr. 5, 69126, Heidelberg, Germany

    P. Drings

  2. Ziegelhäuser Landstraße 65, 69117, Heidelberg, Germany

    I. Vogt-Moykopf

Rights and permissions

Reprints and permissions

Copyright information

© 1998 Springer Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Becher, H., Wahrendorf, J. (1998). Ätiologie und Epidemiologie des Lungenkarzinoms. In: Drings, P., Vogt-Moykopf, I. (eds) Thoraxtumoren. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72041-3_2

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-72041-3_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-72042-0

  • Online ISBN: 978-3-642-72041-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation