Pivotal Role of Lactate in Aerobic Energy Metabolism

  • X. M. Leverve
  • I. Mustafa
  • F. Peronnet
Part of the Yearbook of Intensive Care and Emergency Medicine book series (YEARBOOK, volume 1998)


A defect in the energy status of the cell is believed to play a central role in the pathophysiology of shock and possibly also of other less severe acute disorders. It has been known for a long time that defects in oxidative energy metabolism could be accompanied by increases in blood lactate concentration, and many efforts have been made during the last decades to use blood lactate levels in acutely ill patients to better understand the pathophysiology and the prognosis of the disease as well as the effects of therapeutic approaches [1–9]. However, the metabolic significance of the lactate anion is very broad and an increase in blood lactate concentration cannot be considered only as a marker of a defect in oxidative energy metabolism.


Blood Lactate Pyruvate Dehydrogenase Lactate Production Blood Lactate Concentration Blood Lactate Level 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • X. M. Leverve
  • I. Mustafa
  • F. Peronnet

There are no affiliations available

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