Pivotal Role of Lactate in Aerobic Energy Metabolism
A defect in the energy status of the cell is believed to play a central role in the pathophysiology of shock and possibly also of other less severe acute disorders. It has been known for a long time that defects in oxidative energy metabolism could be accompanied by increases in blood lactate concentration, and many efforts have been made during the last decades to use blood lactate levels in acutely ill patients to better understand the pathophysiology and the prognosis of the disease as well as the effects of therapeutic approaches [1–9]. However, the metabolic significance of the lactate anion is very broad and an increase in blood lactate concentration cannot be considered only as a marker of a defect in oxidative energy metabolism.
KeywordsBlood Lactate Pyruvate Dehydrogenase Lactate Production Blood Lactate Concentration Blood Lactate Level
Unable to display preview. Download preview PDF.
- 12.Thijs LG (1994) Regional or organ blood flow and oxygen consumption: observations in septic shock. Curr Top Intensive Care 1: 101–123Google Scholar
- 22.Reilly E,Yucha CB (1994) Multiple organ failure syndrome. Crit Care Nurse 14: 25–26, 28–31Google Scholar
- 31.Long X, Boluyt MO, Hipolito ML, et al (1997) p53 and the hypoxia-induced apoptosis of cultured neonatal rat cardiac myocytes. J Clin Invest 99: 2635–2643Google Scholar
- 34.Newsholme EA, Leech AR (1990) Control of gluconeogenesis and glycolysis. In: Newsholme EA, Leech AR (eds) Biochemistry for the medical sciences, John Wiley and Sons, Chichester, pp 450–460Google Scholar
- 35.Leverve X (1995) Amino acid metabolism and gluconeogenesis. In: Cynober L (ed) Amino acid metabolism and therapy in health and nutritional disease. CRC Press, New York, pp 45–56Google Scholar
- 52.Tascopoulos M, Magistretti PJ (1996) Metabolic coupling between glia and neurons. J Neurosci 16: 877–885Google Scholar