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The Role of the Host Defense Response in the Progression and Outcome of ARDS

  • Conference paper
Book cover Yearbook of Intensive Care and Emergency Medicine 1998

Part of the book series: Yearbook of Intensive Care and Emergency Medicine ((YEARBOOK,volume 1998))

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Abstract

Acute respiratory distress syndrome (ARDS) describes the clinical syndrome associated with the morphologic lesion termed diffuse alveolar damage (DAD). At presentation, (early) ARDS manifests with acute and diffuse injury to the endothelial and epithelial lining of the terminal respiratory units and causes increased vascular permeability with protein-rich exudative edema. In non-survivors of ARDS, DAD rapidly advances through three histological phases (exudative, fibroproliferative, and fibrotic) with different clinico-physiologic features. The objective of this review is to describe systematically the pathophysiology of unresolving ARDS relating to mechanisms of its development, structural alterations induced in the lung, and functional consequences of these morphologic changes.

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Authors
  1. G. U. Meduri
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Editors and Affiliations

  1. Department of Intensive Care, Erasme Hospital, Free University of Brussels, Route de Lennik 808, B-1070, Brussels, Belgium

    Jean-Louis Vincent (Clinical Director) (Clinical Director)

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© 1998 Springer-Verlag Berlin Heidelberg

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Meduri, G.U. (1998). The Role of the Host Defense Response in the Progression and Outcome of ARDS. In: Vincent, JL. (eds) Yearbook of Intensive Care and Emergency Medicine 1998. Yearbook of Intensive Care and Emergency Medicine, vol 1998. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72038-3_4

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  • DOI: https://doi.org/10.1007/978-3-642-72038-3_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-63798-1

  • Online ISBN: 978-3-642-72038-3

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