Abstract
Sepsis can be defined as the systemic inflammatory response to infection. It is an important cause of morbidity and mortality in hospitalized patients and a predominant cause of prolonged intensive care. The vast majority of intensive care resources is used to treat these patients with sepsis-related states. Despite this, the epidemiology and especially the clinical course of sepsis have not been well described.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Wiles JB, Cerra FB, Siegel JH, Border JR (1980) The systemic septic response: does the organism matter? Crit Care Med 8: 55–60
Shoemaker WC, Appel PL, Kram HB, Bishop MH, Abraham E (1993) Sequence of physiologic patterns in surgical septic shock. Crit Care Med 21: 1876–1889
Vincent J-L (1997) Dear SIRS, I’m sorry to say that I don’t like you… Crit Care Med 25: 372–374
Parrillo JE (1993) Pathogenetic mechanisms of septic shock. N Engl J Med 328: 1471–1477
Bone RC (1991) Sepsis, the sepsis syndrome, multi-organ failure. A plea for comparable definitions. Ann Intern Med 114: 332–333
Rackow EC, Astiz ME, Weil MH (1988) Cellular oxygen metabolism during sepsis and shock. The relationship of oxygen consumption to oxygen delivery. JAMA 259: 1989–1993
Marshall JC, Sweeney (1990) Microbial infection and the septic response in critical surgical illness. Sepsis, not infection, determines outcome. Arch Surg 125: 17–25
Ziegler EJ, Fisher CJ, Sprung CL, et al (1991) Treatment of Gram-negative bacteremia and septic shock with HA-1A human monoclonal antibody against endotoxin. A randomized, double- blinded, placebo-controlled trial. N Engl J Med 324: 429–436
Bone RC, Balk RA, Fein AM, et al (1995) A second large controlled clinical study of E5, a mono¬clonal antibody to endotoxin: Results of a prospective, multicenter, randomized, controlled trial. Crit Care Med 23: 994–1006
American College of Chest Physicians/Society of Critical Care Medicine Consensus Conferences (1992) Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit Care Med 20: 864–874
Rangel-Frausto MS, Pittet D, Costigan M, Hwang T, Davis C, Wenzel RP (1995) The natural history of the systemic inflammatory response (SIRS). A prospective study. JAMA 273: 117–123
Salvo I,, de Cian W, Musicco M et al (1995) The Italian sepsis study: Preliminary results on the incidence and evolution of SIRS, sepsis, severe sepsis and septic shock. Intensive Care Med 21 (suppl 2): S244–S249
Vincent J-L,Bihari DJ,Suter PM,et al (1995) The prevalence of nosocomial infection in intensive care units in Europe. Results of the European prevalence of infection in intensive care (EPIC) study. JAMA 274: 639–644
Brun-Buisson C, Doyon F, Carlet J, et al (1995) Incidence, risk factors, and outcome of severe sepsis and septic shock in adults. A multicenter prospective study in intensive care units. JAMA 274: 968–974
Wildmer A (1994) Infection control and prevention strategies in the ICU. Intensive Care Med 20 (suppl 1):S7–S11
Pittet D, Brun-Buisson C (1996) Nosocomial infections and the intensivist. Curr Opinion Crit Care 2: 345–346
Goldstein EJC (1996) Anaerobic bacteremia. Clin Infect Dis 23: S97–S101
Pfaller M, Wenzel R (1992) Impact of the changing epidemiology of fungal infections in the 1990s. Eur J Clin Microbiol Infect Dis 11: 287–291
Girou E, Brun-Buisson C (1996) Morbidity, mortality, and the cost of nosocomial infections in critical care. Curr Opinion Crit Care 2: 347–351
Wilson RF, Thai AP, Kindling PH, Grifka T, Ackerman E (1965) Hemodynamic measurements in septic shock. Ann Surg 91: 121–129
Parker MM, Shelhamer JH, Natanson C, Ailing DW, Parrillo JE (1987) Serial cardiovascular variables in survivors and nonsurvivors of human septic shock: Heart rate as an early predictor of prognosis. Crit Care Med 15: 923–929
Ilkka L, Takala J (1996) Hemodynamic pattern preceding septic shock. Intensive Care Med 22 (suppl 2): S329 (Abst)
Parker MM, Shelhamer JH, Bacharach SL, et al (1984) Profound but reversible myocardial de¬pression in patients with septic shock. Ann Intern Med 100: 483–490
Parrillo JE, Burch C, Shelhamer JH, Parker MM, Natanson C, Schuette W (1985) A circulating myocardial depressant substance in humans with septic shock. J Clin Invest 76: 1539–1553
Natanson C, Eichenholz PW, Danner RL, et al (1989) Endotoxin and tumor necrosis factor challenges in dogs simulate the cardiovascular profile of human septic shock. J Exp Med 169: 823–832
Danner RL, Elin RJ, Hosseini JM, Wesley RA, Reilly JM, Parrillo JE (1991) Endotoxemia in human septic shock. Chest 99: 169–175
Lorente JA, Landin L, Renes E, et al (1993) Role of nitric oxide in the hemodynamic changes of sepsis. Crit Care Med 21: 759–767
Takala J, Guntupalli K, Donaldson J, Watson D (1997) Multicentre, placebo-controlled, double- blind study of the nitric oxide synthase inhibitor 546C88 in patients with septic shock: effect on early non-cardiovascular organ function. Intensive Care Med 23 (suppl 1): S51 (Abst)
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1998 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Ilkka, L., Parviainen, I., Takala, J. (1998). Do We Really Know the Epidemiology and Clinical Course of Sepsis?. In: Vincent, JL. (eds) Yearbook of Intensive Care and Emergency Medicine 1998. Yearbook of Intensive Care and Emergency Medicine, vol 1998. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72038-3_20
Download citation
DOI: https://doi.org/10.1007/978-3-642-72038-3_20
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-63798-1
Online ISBN: 978-3-642-72038-3
eBook Packages: Springer Book Archive