Selective Pharmacological Inhibition of Inducible Nitric Oxide Synthase in Experimental Septic Shock

  • L. Liaudet
  • M. D. Schaller
  • F. Feihl
Conference paper
Part of the Yearbook of Intensive Care and Emergency Medicine book series (YEARBOOK, volume 1998)


In spite of major advances in the care of critically ill patients, septic shock remains a commonly fatal condition, with a mortality rate averaging 50% [1], Recent progress in the understanding of the pathophysiology of septic shock has prompted an intense search for new therapeutic modalities. In particular, the recognition that an enhanced production of the vasodilator nitric oxide (NO) from an inducible isoform of NO synthase (iNOS) plays a major role in sepsis-induced hypotension, has suggested that the pharmacological inhibition of iNOS might be of great therapeutic value in this setting [2]. In this article, we will review the current state of knowledge regarding the inhibition of NO production in experimental septic shock, by focusing on the most recent data obtained with the newly developed selective inhibitors of iNOS.


Nitric Oxide Septic Shock Multiple Organ Dysfunction Syndrome Amino Guanidine Nitric Oxide Synthesis 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • L. Liaudet
  • M. D. Schaller
  • F. Feihl

There are no affiliations available

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