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Selective Pharmacological Inhibition of Inducible Nitric Oxide Synthase in Experimental Septic Shock

  • Conference paper
Yearbook of Intensive Care and Emergency Medicine 1998

Part of the book series: Yearbook of Intensive Care and Emergency Medicine ((YEARBOOK,volume 1998))

Abstract

In spite of major advances in the care of critically ill patients, septic shock remains a commonly fatal condition, with a mortality rate averaging 50% [1], Recent progress in the understanding of the pathophysiology of septic shock has prompted an intense search for new therapeutic modalities. In particular, the recognition that an enhanced production of the vasodilator nitric oxide (NO) from an inducible isoform of NO synthase (iNOS) plays a major role in sepsis-induced hypotension, has suggested that the pharmacological inhibition of iNOS might be of great therapeutic value in this setting [2]. In this article, we will review the current state of knowledge regarding the inhibition of NO production in experimental septic shock, by focusing on the most recent data obtained with the newly developed selective inhibitors of iNOS.

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Authors
  1. L. Liaudet
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  2. M. D. Schaller
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  3. F. Feihl
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Editors and Affiliations

  1. Department of Intensive Care, Erasme Hospital, Free University of Brussels, Route de Lennik 808, B-1070, Brussels, Belgium

    Jean-Louis Vincent (Clinical Director) (Clinical Director)

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© 1998 Springer-Verlag Berlin Heidelberg

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Liaudet, L., Schaller, M.D., Feihl, F. (1998). Selective Pharmacological Inhibition of Inducible Nitric Oxide Synthase in Experimental Septic Shock. In: Vincent, JL. (eds) Yearbook of Intensive Care and Emergency Medicine 1998. Yearbook of Intensive Care and Emergency Medicine, vol 1998. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72038-3_15

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  • DOI: https://doi.org/10.1007/978-3-642-72038-3_15

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-63798-1

  • Online ISBN: 978-3-642-72038-3

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