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Leukocyte Integrins in the Immune System and Malignant Disease pp 65–83Cite as

The Roles of α4-Integrins in the Development of Insulin-Dependent Diabetes Mellitus

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Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 231))

Abstract

Most lymphocytes recirculate throughout the body, migrating from blood through organized lymphoid tissues such as lymph nodes (LN) and Peyer’s patches (PP), then to lymph and back to blood (Gowans and Knight 1964). Smaller numbers of lymphocytes migrate from blood to extranodal tissues such as pancreas and then through lymphatic vessels to LN (Mackay et al. 1990). An important feature of this migration is the ability of lymphocytes to recognize and adhere to the surface of blood vessel endothelial cells before migrating through the vessel wall into surrounding tissue (Carlos and Harlan 1994; Imhof and Dunon 1995; Butcher and Picker 1996).

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Authors and Affiliations

  1. Department of Veterans Affairs, Palo Alto Health Care System, Center for Molecular Biology in Medicine, Palo Alto, CA, 94304, USA

    S. A. Michie

  2. Department of Pathology, Stanford University School of Medicine, Stanford, CA, 94305-5324, USA

    S. A. Michie

  3. Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, 94305-5402, USA

    H.-K. Sytwu & J. O. McDevitt

  4. Department of Medicine, Stanford University School of Medicine, Stanford, CA, 94305-5111, USA

    J. O. McDevitt

  5. Division of Preclinical Research, Abgenix, Inc., Fremont, CA, 94555, USA

    X.-D. Yang

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  1. S. A. Michie
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  3. J. O. McDevitt
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  1. Institute of Medical Microbiology, Immunology, and Hygiene, Technical University of Munich, Trogerstr. 9, D-81675, Munich, Germany

    Bernhard Holzmann M.D.  & Hermann Wagner M.D., Ph.D.  & 

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Michie, S.A., Sytwu, HK., McDevitt, J.O., Yang, XD. (1998). The Roles of α4-Integrins in the Development of Insulin-Dependent Diabetes Mellitus. In: Holzmann, B., Wagner, H. (eds) Leukocyte Integrins in the Immune System and Malignant Disease. Current Topics in Microbiology and Immunology, vol 231. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71987-5_5

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