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The Ups and Downs of α2β1-Integrin Expression: Contributions to Epithelial Cell Differentiation and the Malignant Phenotype

  • Chapter
Leukocyte Integrins in the Immune System and Malignant Disease

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 231))

Abstract

The integrins are a family of cell surface adhesion receptors that mediate adhesion to either components of the extracellular matrix or to other cells. The integrins are noncovalently associated, heterodimeric glycoproteins composed of distinct α and β subunits of which at least 14 α and nine β subunits have been identified (Ruoslahti 1991; Hynes 1992; Albelda 1993). The β1 family of integrins represent the major class of cell substrate receptors with specificities primarily for collagens, laminins, and fibronectins. Ligand specificity is a function of the particular α-β combination with a great deal of apparent redundancy within the system. For example, many integrins may bind a given extracellular matrix molecule and a single integrin may bind more than one matrix molecule. Recent evidence from several laboratories suggests that some of the apparent redundancy observed at the level of adhesion is not at all redundancy since each receptor may mediate distinct post-receptor occupancy events such as cell differentiation (Dedhar et al. 1987; Reichardt and Tomaselli 1991), alteration in gene expression (Werb et al. 1989; Damsky and Werb 1992), ion fluxes through membrane channels (Schwartz and Denninghoff 1994), and regulation of tumor progression, invasion and metastasis.

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Authors and Affiliations

  1. Department of Pathology, Division of Anatomic Pathology, Barnes Hospital, 1 Barnes Plaza, Washington University School of Medicine, St. Louis, MO, 63110, USA

    M. M. Zutter & S. A. Santoro

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  1. M. M. Zutter
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  2. S. A. Santoro
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  1. Institute of Medical Microbiology, Immunology, and Hygiene, Technical University of Munich, Trogerstr. 9, D-81675, Munich, Germany

    Bernhard Holzmann M.D.  & Hermann Wagner M.D., Ph.D.  & 

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© 1998 Springer-Verlag Berlin Heidelberg

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Zutter, M.M., Santoro, S.A. (1998). The Ups and Downs of α2β1-Integrin Expression: Contributions to Epithelial Cell Differentiation and the Malignant Phenotype. In: Holzmann, B., Wagner, H. (eds) Leukocyte Integrins in the Immune System and Malignant Disease. Current Topics in Microbiology and Immunology, vol 231. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71987-5_10

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  • DOI: https://doi.org/10.1007/978-3-642-71987-5_10

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  • Print ISBN: 978-3-642-71989-9

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