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Lymphocyte Development and Selection in Germinal Centers

  • Chapter
Somatic Diversification of Immune Responses

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 229))

Abstract

Germinal centers (GCs) represent an intense focal proliferation of antigen-specific B and T lymphocytes within a reticulum of follicular dendritic cells (FDCs). Newly formed GCs contain oligoclonal populations of lymphocytes that interact by cell-to-cell contact (Jacob et al. 1991a; Liu et al. 1991b; MacLennan 1994; Han et al. 1995a; Kelsoe 1995; Ferguson et al. 1996). These collaborations are necessary for the maintenance of the GC reaction, efficient activation of V(D)J hypermutation and selection, and the generation of memory B cells (Han et al. 1995a). By supporting these processes, the GC microenvironment controls and directs major pathways of antigen-dependent lymphocyte differentiation.

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  1. Department of Microbiology and Immunology, University of Maryland School of Medicine, 655 West Baltimore Street, Baltimore, MD, 21201, USA

    J. Przylepa, C. Himes & G. Kelsoe

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  1. J. Przylepa
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  2. C. Himes
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Editors and Affiliations

  1. Department of Microbiology and Immunology, University of Maryland School of Medicine, 655 W. Baltimore Street, Baltimore, MD, 21201, USA

    Garnett Kelsoe D. Sc.

  2. Department of Microbiology and Immunology, University of Miami School of Medicine, 1600 NW 10th Avenue, Miami, FL, 33136, USA

    Martin F. Flajnik Ph.D.

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Przylepa, J., Himes, C., Kelsoe, G. (1998). Lymphocyte Development and Selection in Germinal Centers. In: Kelsoe, G., Flajnik, M.F. (eds) Somatic Diversification of Immune Responses. Current Topics in Microbiology and Immunology, vol 229. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71984-4_8

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