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Dermatologie pp 116-118 | Cite as

Gesteigerte Aktivität von Protein-Tyrosinkinasen in dendritischen Zellen unter Stimulation mit Kontaktallergenen

  • D. Becker
  • U. Kühn
  • J. Willemsen
  • R. van Brandwijk-Petershans
  • J. Knop
Conference paper

Zusammenfassung

Kontaktallergene sind in der Lage, antigenpräsentie- rende Zellen, wie z. B. epidermale Langerhans-Zellen (LZ), zu aktivieren. Als wesentliche Bestandteile der Aktivierung wurden die frühe Induktion der Synthese und Ausschüttung von IL-1β [1], eine vermehrte Endozytose von MHC-Klasse II-Molekülen [2,3], phä-notypische Veränderungen wie die Abnahme von Adhäsionsmolekülen [4] und die Heraufregulation von MHC Molekülen und kostimulatorischen Rezeptoren [5] beschrieben.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • D. Becker
  • U. Kühn
  • J. Willemsen
  • R. van Brandwijk-Petershans
  • J. Knop

There are no affiliations available

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