Abstract
About 15% of patients with colorectal cancer report a family history of this disease. An estimated 1%–5% of patients have hereditary non-polyposis colorectal cancer (HNPCC). Recently, DNA mismatch repair genes associated with this syndrome were identified. For about 50% of families in which HNPCC occurs, DNA-based diagnosis and presymptomatic DNA testing are now feasible. Diagnosis of a hereditary tumour syndrome is relevant for both the patient with cancer and his or her close relatives. The complexities of family studies warrant the forming of a multidisciplinary team which may choose to work within a specialized cancer family clinic.
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Menko, F.H., Wijnen, J.T., Vasen, H.F.A., Sijmons, R.H., Khan, P.M. (1998). Familial and Hereditary Non-polyposis Colorectal Cancer: Issues Relevant for Surgical Practice. In: Schlag, P.M. (eds) Rectal Cancer. Recent Results in Cancer Research, vol 146. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71967-7_2
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DOI: https://doi.org/10.1007/978-3-642-71967-7_2
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