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Molecular Pathology of Colorectal Cancer: From Phenotype to Genotype

  • Conference paper
Rectal Cancer

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 146))

Abstract

In the West, colorectal cancer is the second most common cancer in males and the third among females, with about 180 000 new cases being diagnosed per year in Western Europe. The overall 5-year mortality rate is 50–60% after complete tumor removal (R0), whereas it is very poor after R1/2 resections. Once the tumor has metastazised, almost all therapeutic approaches — chemotherapy with cytostatic drugs, immunotherapy with monoclonal antibodies directed to surface (glyco-)proteins of the tumor cells, gene therapy with transduction of genes to stimulate antitumor inflammation or to reconstitute mutations, and several others — have proved to be of limited efficacy.

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Authors and Affiliations

  1. Institute of Pathology, University Hospital Charité, Humboldt University of Berlin, Schumannstrasse 20-21, 10117, Berlin, Germany

    M. Dietel

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  1. M. Dietel
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Editors and Affiliations

  1. Klinik für Chirurgie und Chirurgische Onkologie, Universitätsklinikum Charité, Robert-Rössle-Klinik, Lindenberger Weg 80, D-13125, Berlin, Germany

    Peter M. Schlag

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© 1998 Springer-Verlag Berlin · Heidelberg

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Dietel, M. (1998). Molecular Pathology of Colorectal Cancer: From Phenotype to Genotype. In: Schlag, P.M. (eds) Rectal Cancer. Recent Results in Cancer Research, vol 146. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71967-7_1

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  • DOI: https://doi.org/10.1007/978-3-642-71967-7_1

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-71969-1

  • Online ISBN: 978-3-642-71967-7

  • eBook Packages: Springer Book Archive

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