Experience with BFM 1990 Protocol Treatment of Recurrent Childhood Lymphoblastic Leukemia. Report of the Polish Children’s Leukemia/Lymphoma Study Group
Between 1993 and 1996,54 children aged from 6 mths-18 years (16 girls and 38 boys) with first relapse of acute lymphoblastic leukemia were included to the study. The children were treated according to the BFM 90 relapse protocol. There were 40 cases with early (including 14 children with very early) and 14 cases with late relapse (BM-30, local-12, combined 12). The probability of EFS were calculated according to the Kaplan-Meier method.
The overall second complete remission (CR) rate in very early was 71.42%, in early relapse was 73.07% and in late relapse 78.57%. The probability of overall event-free survival (EFS) after 2 years was 39.9%. The EFS achieved in children with late relapses was four times higher when compared with early and very early relapses 73.2% vs. 59% vs.29.2% (p = 0.05).
The results obtained with BFM 90 chemotherapy in children with first late relapse are acceptable. One must conclude that for children with early relapses, other chemotherapy methods together with BMT in second remission should be applied.
KeywordsToxicity Lymphoma Leukemia Oncol Dexamethasone
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