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Expression of Differentiation Antigens on Blast Cells of Acute Myelogenous Leukemia (AML, M0–M6)

  • I. Abramenko
  • D. Gluzman
  • N. Bilous
  • V. Chromyak
  • L. Sklyarenko
  • S. Andreeva
Conference paper
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 39)

Abstract

Forty one patients with AML (M01 4 patients, M11 5, M21 7, M41 8, M5a1 16, and M61 one patient) have been studied. Cytochemical reactions (MPO, CAE, AcP, ANAE, NE, PAS) and immunological detection of antigens expression (indirect immunoperoxidase, APAAP methods and, in some cases, flow cytometry) were performed. The definition of typical phenotypical pattern for discrete FAB-variants AML was carried out. Significant heterogeneity of monoblasts was revealed. Cases of AML, M5a with unusual phenotypical features were discovered. Its origin from hierarchy of hematopoietic stem cells is discussed.

Keywords

acute myelogenous leukemia monoblastic leukemia hematopoietic progenitor cells stem cells antigen expression 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • I. Abramenko
  • D. Gluzman
  • N. Bilous
  • V. Chromyak
  • L. Sklyarenko
  • S. Andreeva

There are no affiliations available

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