Hematopoietic Growth Factors: Supportive and Priming Effects in AML
Growth factors have been administered after chemotherapy in 12 studies. Eight studies showed benefits in neutropenia and seven studies benefits in infections or survival or remissions. Clinical benefits are mainly found in high-risk patients. There are five negative studies according to major benefits, all five studies using E. coli produced GM-CSF. Growth factors before or together with chemotherapy were given in nine studies with trends to more remissions in one and to longer disease-free survival in three studies. Extending the priming strategy to more chemotherapy courses than having been done so far may further improve the antileukemic effect.
KeywordsPlacebo Toxicity Europe Leukemia Neutropenia
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