Excessive Differentiation of Myeloid Cells in AML-M2 with Translocation 8;21
t(8;21) is a chromosomal abnormality found in a part of AML-M2 cases and exceptionally in other blood disorders. According to literature data, CR in this form of M2 is easy to obtain and therefore BMT is not recommended in the first remission. We report here on 3 patients observed in the past 3 years, in whom blood disease was firstly diagnosed as blast crisis/acceleration of CML, because of an excessive differentiation of their leukemic cells and low FAG scores. These results prompted us to diagnose BC/ACC-CML and to administer a proper therapy. However, cytogenetic examination of BM cells of the patients did not confirm the diagnosis: t(8;21) and no Ph chromosome was found in all samples examined, which enabled us to change the diagnosis. During the course of the disease a disappea-rance of t(8;21) in remissions and reappearance in relapses was revealed. t(8;21) is very rarely seen in BC-CML of M2 type and was never described in Ph(-) CML. Our observation confirm that of Yamasaki and co. that t(8;21) M2 may show an excessive differentiation of the myeloid cell line.
KeywordsAcute Myeloid Leukemia Partial Remission Granulocytic Sarcoma Acute Myeloid Leukemia Cell Line Cytogenetic Examination
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