Transformation of Myeloid Cells by the BCR/ABL Oncogene

  • J. D. Griffin
  • M. Sattler
  • N. Uemura
  • K. Okuda
  • R. Salgia
Conference paper
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 39)


BCR/ABL transforms hematopoietic cells in vitro and in vivo and exerts a wide variety of biological effects, including induction of factor-independence, reduction of apoptosis, and altering adhesion of CML cells to marrow stroma. However, at a biochemical level, the mechanisms by which BCR/ABL transforms myeloid cells remain poorly understood. p210BCR/ABL has elevated ABL tyrosine kinase activity, relocates to the cytoskeleton, and phosphorylates many cellular signaling proteins. Recent advances in identifying the substrates of the ABL tyrosine kinase have led to a better understanding of the mechanism of transformation. A variety of signaling pathways are activated by p210BCR/ABL, including those involving p2lras, PI3K, and CRKL. Considerable progress has been made linking each of these pathways to specific biological and clinical abnormalities in CML.


Focal Adhesion Focal Adhesion Protein Tyrosine Kinase Oncogene Protein CRKL Cellular Signaling Protein 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • J. D. Griffin
    • 1
  • M. Sattler
    • 1
  • N. Uemura
    • 1
  • K. Okuda
    • 1
  • R. Salgia
    • 1
  1. 1.Dana-Farber Cancer InstituteBostonUSA

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