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Marrow Transplants from Unrelated Donors for the Treatment of High-Risk Acute Leukemia

  • Conference paper
Acute Leukemias VII

Part of the book series: Haematology and Blood Transfusion / Hämatologie und Bluttransfusion ((HAEMATOLOGY,volume 39))

  • 138 Accesses

Abstract

Transplantation of allogeneic stem cells has become a well established treatment for a variety of hematological malignancies including poor-risk acute leukemias [1]. This procedure has the highest probability of success if donor and recipient are closely HLA-matched. For patients without a suitable relative, one option is to identify an HLA-identical unrelated volunteer donor [2]. Despite the enormous polymorphism of HLA genes, the probability of finding a compatible unrelated donor is increasing since the international registries contain now more than 3.5 million HLA-typed volunteers. Shortening the time needed for the donor search has made unrelated donor bone marrow transplants (URD-BMT) a realistic alternative for the treatment of patients with acute leukemia. Five-hundred ninety-five URD-BMT were facilitated by the U.S. National Marrow Donor Program (NMDP) for the treatment of acute leukemias between 1989 and 1993 [3].

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Authors and Affiliations

  1. Hematology Department, Hospital Clinic, University of Barcelona, Barcelona, Spain

    J. Sierra

  2. Fred Hutchinson Cancer Research Center, Seattle, Washington, USA

    J. W. Bjerke, J. A. Hansen, P. J. Martin, E. W. Petersdorf & C. Anasetti

  3. University of Washington, Seattle, Washington, USA

    J. A. Hansen, P. J. Martin, E. W. Petersdorf & C. Anasetti

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  1. J. Sierra
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  2. J. W. Bjerke
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  3. J. A. Hansen
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  4. P. J. Martin
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  5. E. W. Petersdorf
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  6. C. Anasetti
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Editors and Affiliations

  1. Department of Internal Medicine, University of Göttingen, Robert-Koch-Straße 40, 37075, Göttingen, Germany

    W. Hiddemann  & B. Wörmann  & 

  2. Department of Internal Medicine, USA

    T. Büchner

  3. Department of Pediatrics, University of Münster, Albert-Schweitzer-Straße 33, 48149, Münster, Germany

    J. Ritter  & U. Creutzig  & 

  4. Dept. of Hematology, University of Texas, Anderson Cancer Center, 1515 Holcombe Boulevard, 77030, Houston, Tx., USA

    M. Keating MD PhD  & W. Plunkett MD PhD  & 

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Sierra, J., Bjerke, J.W., Hansen, J.A., Martin, P.J., Petersdorf, E.W., Anasetti, C. (1998). Marrow Transplants from Unrelated Donors for the Treatment of High-Risk Acute Leukemia. In: Hiddemann, W., et al. Acute Leukemias VII. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, vol 39. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71960-8_156

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