Immunophenotypical Subtype of Childhood T-All with Favourable Outcome in the COALL 1985–1992 Study Group

  • T. Niehues
  • P. Kapaun
  • D. Harms
  • H. Kabisch
  • S. Burdach
  • G. Janka-Schaub
  • U. Göbel
Conference paper
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 39)


Physiologically, T-cell differentiation involves passage through the thymic cortex, where approximately 90% of the T-cells will be eliminated by apoptosis. This thymic cortical T-cell population is called selection-related (SR) and can be identified by a distinct pattern of surface marker expression (CD1+CD4+8+).

Aims of the study: as malignant transformation can occur at different stages of T-cell differentiation we asked the following questions:
  1. 1.

    What percentage of T-ALL cases are of SR phenotype?

  2. 2.

    Does SR phenotype confer a different prognosis under standard leukemia therapy?



Acute Lymphoblastic Leukemia Mediastinal Mass Leukemic Blast Childhood Acute Lymphoblastic Leukemia Myeloid Marker 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • T. Niehues
    • 1
  • P. Kapaun
    • 2
  • D. Harms
    • 2
  • H. Kabisch
    • 2
  • S. Burdach
    • 1
  • G. Janka-Schaub
    • 2
  • U. Göbel
    • 1
  1. 1.Dept. of Pediatric HematologyGermany
  2. 2.Depts. of OncologyUniversities of Düsseldorf and HamburgGermany

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