Oral Idarubicin in the Treatment of AML

  • J.-L. Harousseau
Conference paper
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 39)

Abstract

The current treatment of Acute Myeloid Leukemia (AML) is based on intensive chemotherapy at different steps (induction treatment, consolidation, treatment of relapse). Since these strategies induce prolonged and severe myelosuppression, all patients are nursed in specialized units and receive a number of intravenous supportive treatments (antibiotics, antifungal treatments, red blood cell and platelet transfusions, parenteral nutrition, etc.) which are administered through a central line. Therefore the place of oral chemotherapy appears very limited in the overall management of AML.

However, in some cases, giving an orally effective antileukemic drug partly on an outpatient basis could be an attractive alternative. These conditions include palliative therapy of relapsed or refractory AML, consolidation (or maintenance) therapy and induction therapy in poor-risk patients. Elderly patients represent the most important cohort in the latter category.

Keywords

Placebo Lymphoma Leukemia Oncol Doxorubicin 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • J.-L. Harousseau
    • 1
  1. 1.Service d’Hématologie CliniqueCHU de NantesNantes CedexFrance

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