Advertisement

Treatment of Ph+ and t(4;11)+ Acute Lymphoblastic Leukemia in Adults

  • H. Martin
  • N. Goekburget
  • J. Atta
  • W.-D. Ludwig
  • D. Hoelzer
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 39)

Abstract

About 20–25% of adult patients with acute lymphoblastic leukemia (ALL) present with a Philadelphia chromosome t(9;22) as cytogenetic marker and/or on a molecular level with the corresponding BCR-ABLrearrangement [1–4]. The proportion of ALL-patients with Ph+/BCR-ABL+ ALL increases with age. The median age of patients with BCR-ABL+ ALL in the German multicenter adult ALL (GMALL) trials is 45 years [4].

Keywords

Acute Lymphoblastic Leukemia Minimal Residual Disease Childhood Acute Lymphoblastic Leukemia Matched Unrelated Donor Phoblastic Leukemia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Bloomfield CD, Goldman AI, Alimena G, Berger R, Borgstroem GH, Brandt L, Catovsky D, de la Chapelle A, Dewald GW et al (1986) Chromosomal abnormalities identify high-risk and low-risk patients with acute lymphoblastic leukemia. Blood 67 (2): 415PubMedGoogle Scholar
  2. 2.
    Seeker-Walker LM, Craig JM, Hawkins JM, Hoff-brand AV (1990) Philadelphia positive acute lymphoblastic leukemia in adults: age distribution, bcr breakpoint and prognostic significance. Leukemia 5: 196Google Scholar
  3. 3.
    Maurer J, Jannsen JWG, Thiel E, van Denderen J, Ludwig WD, Aydemir O, Heinze B, Fonatsch C, Harbott J, Reiter A, Riehm H, Hoelzer D, Bartram CR (1991) Detection of chimeric BCR-ABL genes in acute lymphoblastic leukemia by the polymerase chain reaction. Lancet 337: 1055PubMedCrossRefGoogle Scholar
  4. 4.
    Hoelzer D (1994) Treatment of acute lymphoblastic leukemia. Semin Hematol 31: 1PubMedGoogle Scholar
  5. 5.
    Yokota S, Hansen-Hagge TE, Ludwig WD, Reiter A, Raghavachar A, Kleihauer E, Bartram CR (1991) Use of polymerase chain reactions to monitor minimal residual disease in acute lymphoblastic leukemia patients. Blood 77: 331PubMedGoogle Scholar
  6. 6.
    Atta J, Martin H, Bruecher J, Elsner S, Wassmann B, Rode C, Russ A, Kvalheim G, Hoelzer D (1996) Residual disease and immunomagnetic bead purging in patients with BCR-ABL-positive acute lymphoblastic leukemia. Bone Marrow Transplant 18: 541PubMedGoogle Scholar
  7. 7.
    Brennan C, Weisdorf D, Kersey J, Haake R, Ramsay N (1991) Bone marrow transplantation for Philadelphia chromosome-positive acute lymphoblastic leukemia. Proc ASCO 10: 222Google Scholar
  8. 8.
    Gehly GB, Bryant EM, Lee AM, Kidd PG, Thomas ED (1991) Chimeric BCR-abl messenger RNA as a marker for minimal residual disease in patients transplanted for Philadelphia chromosome-positive acute lymphoblastic leukemia. Blood 78: 458PubMedGoogle Scholar
  9. 9.
    Miyamura K, Tanimoto M, Morishima Y, Horibe K, Yamamoto K, Akatsuka M, Kodera Y, Kojima S, Matsauyama K, Hirabayashi N,Yazaki M, Imai K, Onozawa Y, Kanamaru A, Mizutani S, Saito H (1992) Detection of Philadelphia chromosome positive acute lymphoblastic leukemia by polymerase chain reaction: possible eradication of minimal residual disease by marrow transplantation. Blood 79: 1366PubMedGoogle Scholar
  10. 10.
    Barrett AJ, Horowitz MM, Ash RC, Atkinson K, Gale RP, Goldman JM, Henslee-Downey PJ, Herzig RH, Speck B, Zwaan FE, Bortin MM: Bone marrow transplantation for Philadelphia chromosome-positive acute lymphoblastic leukemia. Blood 79: 3067Google Scholar
  11. 11.
    Stockschläder M, Hegewisch-Becker S, Krüger W, tom Dieck A, Hoffknecht M, Berger C, Kohlschütter B, Martin H, Peters S, Kabisch H, Kuse R, Weh H, Zander A (1995) Bone marrow transplantation for Philadelphia-chromosome positive acute lymphoblastic leukemia. Bone Marrow Transplant 16: 663PubMedGoogle Scholar
  12. 12.
    Chao NJ, Blume KG, Forman SJ, Snyder DS (1995) Long-term follow-up of allogeneic bone marrow recipients for Philadelphia chromosome-positive acute lymphoblastic leukemia. Blood 85: 3353PubMedGoogle Scholar
  13. 13.
    Casper J, Camitta B, Ash R, Unin N, Pietriyga D, Garbrecht F, Baxter-Lowe LA, Murray K, Lawton C, Truitt R, Keever C, Flomenb erg N (1992) Bone marrow transplantation for Philadelphia chromosome positive (Ph+) acute lymphocytic leukemia (ALL) using alternative donors. Blood 80 Suppl I: 65aGoogle Scholar
  14. 14.
    Mitterbauer G, Fodinger M, Scherrer R, Knobl P, Jager U, Laczika K, Schwarzinger I, Gaiger A, Geissler K, Greinix H et al. (1995) PCR- monitoring of minimal residual leukaemia after conventional chemotherapy and bone marrow transplantation in BCR-ABL-positive acute lymphoblastic leukaemia [published erratum appears in Br J Haematol 1995 Jun; 90(2): 492]. Br J Haematol 89: 937Google Scholar
  15. 15.
    Powles R,Mehta J, Singhal S, Horton C, Tai D, Milan S, Pollard C, Lumley H, Matthey F, Shirley J, Williams H, Samaratunga I, Lakhani A, Millar J, Treleaven J (1995) Autologous bone marrow transplantation or peripheral blood stem cell transplantation followed by maintenance chemotherapy for adult acute lymphoblastic leukemia in first remission: 50 cases from a single center. Bone Marrow Transplant 16: 241PubMedGoogle Scholar
  16. 16.
    Martin H, Atta J, Wassmann B, Ottmann OG, Ott MG, Fauth F, Bergmann L, Gramatzki M, Stockschläder M, Bunjes D, Arnold R, Hoelzer D (1997) Autologous bone marrow transplantation in patients with BCR-ABL-positive acute lymphoblastic leukemia. Bone Marrow Transplant 19: S101CrossRefGoogle Scholar
  17. 17.
    Martin H, Atta J, Zumpe P, Eder M, Elsner S, Rode C, Wassmann B, Bruecher J, Hoelzer D (1995) Purging of peripheral blood stem cells yields BCR-ABL-negative autografts in patients with BCR-ABL-positive acute lymphoblastic leukemia. Exp Hematol 23: 1612PubMedGoogle Scholar
  18. 18.
    Martin H, Atta J, Bruecher J, Elsner S, Schardt C, Stadler M, von Melchner H, Hoelzer D (1994) In patients with BCR-ABL-positive ALL in CR peripheral blood contains less residual disease than bone marrow: implications for autologous BMT. Ann Hematol 68: 85PubMedCrossRefGoogle Scholar
  19. 19.
    Pui C-H, Kane JR, Crist WM (1995) Biology and treatment of infant leukemias. Leukemia 9: 762PubMedGoogle Scholar
  20. 20.
    Rubnitz JE, Behm F, Downing JR (1996) 11q23 rearrangements in acute leukemia. Leukemia 10: 74PubMedGoogle Scholar
  21. 21.
    Secker-Walker LM, Prentice HG, Durrant J, Richards S, Hall E, Harrison G (1997) Cytogenetics adds independent prognostic information in adults with acute lymphoblastic leukaemia on MRC trial UKALLL XA. Br J Haematol 96: 601PubMedCrossRefGoogle Scholar
  22. 22.
    Charrin C (1996) Cytogenetic abnormalities in adult acute lymphoblastic leukemia: Correlations with hematologic findings and outcome. A collaborative study of the Groupe Francais de Cytogénétique Hématologique. Blood 87: 3135Google Scholar
  23. 23.
    Ziemin-van der Poel S, McCabe NR, Gill HJ, Espinosa R, Patel Y, Harden A, Rubinelli P, Smith SD, LeBeau MM, Rowley JD, Diaz MO (1991) Identification of a gene, MLL, that spans the breakpoint in 11q23 translocations associated with human leukemias. Proc Natl Acad Sci USA 88: 10735CrossRefGoogle Scholar
  24. 24.
    Griesinger F, Jahn T, Elfers H, Ludwig W-D, Falk M, Rieder H, Harbott J, Lampert F, Heinze B, Hoelzer D, Thiel E, Riehm H, Wörman B, Fonatsch C, Hiddemann W (1996) Heterogeneity of HRX-FEL fusion transcripts in adult and pediatric t(4;11) ALL. In: Hiddemann et al (ed) Acute Leukemias V: Experimental Approaches and Management of Refractory Diseases. Springer, Berlin Heidelberg, p 15Google Scholar
  25. 25.
    Pui C-H, Lawrence D, Frankel S, Carroll A, Rai-mondi S, Shuster J, Head D, Crist W, Land V, Pullen J, Steuber CP, Behm F, Borowitz M (1991) Clinical characteristics and treatment outcome of childhood acute lymphoblastic leukemia with the t(4;11) (q21;q23): A collaborative study of 40 cases. Blood 77: 440PubMedGoogle Scholar
  26. 26.
    Cimino G, Rapanotti MC, Rivolta A, Lo Coco F, D’Arcangelo E, Rondelli R, Basso G, Barisone E, Rosanda C, Santostasi T, Canaani E, Masera G, Mandelli F, Biondi A (1995) Prognostic relevance of ALL-1 gene rearrangement in infant acute leukemias. Leukemia 9: 391PubMedGoogle Scholar
  27. 27.
    Bene MC, Castoldi G, Knapp W, Ludwig W-D, Matutes E, Orfao A, van’t Veer MB (1995) Proposal for the immunological classification of acute leukemias. Leukemia 9: 1783PubMedGoogle Scholar
  28. 28.
    Garand R, Bene MC (1993) Incidence, clinical and laboratory features, and prognostic significance of immunophenotypic subgroups in acute lymphoblastic leukemia: the GEIL experience. Recent Res Cancer Res 131: 283CrossRefGoogle Scholar
  29. 29.
    Ludwig W-D, Raghavachar A, Thiel E (1994) Immunophenotypic classification of acute lymphoblastic leukemia. Bailliere’s Clinical Haematology 7: 235PubMedCrossRefGoogle Scholar
  30. 30.
    Basso G, Rondelli R, Putti MC, Rajnoldi AC, Granchi D, Cocito MG, Saitta M et al. (1993) Incidence and prognostic significance of immunopheotypic subgroups in childhood acute lymphoblastic leukemia: the experience of the AIEOP cooperative study. Recent Res Cancer Res 131: 297CrossRefGoogle Scholar
  31. 31.
    Ludwig WD, Harbott J, Rieder H, Bartram CR, Maurer J, Becher R, Heinze B, Gassmann W, Drexler HG, Martin M, Sperling C, Völkers B, Reiter A, Ritter J, Hiddemann W, Büchner T, Löffler H, Fonatsch C, Hoelzer D, Riehm H, Thiel E (1994) Incidence, Biologic features and treatment outcome of myeloid-antigen-positive acute lymphoblastic leukemia (My+ ALL). In: Büchner et al. (ed) Acute leukemias I V. Prognostic factors. Springer, Berlin Heidelberg New YorkGoogle Scholar
  32. 32.
    Hilden JM, Frestedt JL, Moore RO, Heerema NA, Arthur DC, Reaman GH, Kersey JH (1995) Molecular analysis of infant acute lymphoblastic leukemia: MLL gene rearrangement and reverse transcriptase-polymerase chain reaction for t(4;11) (q21;q23). Blood 86: 3876PubMedGoogle Scholar
  33. 33.
    Behm F, Raimondi S, Frestedt JL, Liu Q, Crist W, Downing JR, Rivera GK, Kersey J, Pui C-H (1996) Rearrangement of the MLL gene confers a poor prognosis in childhood acute lymphoblastic leukemia, regardless of presenting age. Blood 87: 2870PubMedGoogle Scholar
  34. 34.
    Janssen JWG, Ludwig W-D, Borkhardt A, Spadinger U, Rieder H, Fonatsch C, Hossfeld D, Harbott J, Schulz AS, Repp R, Sykora K-W, Hoelzer D, Bartram CR (1994) Pre-pre-B Acute lymphoblastic leukemia: high frequency of alternatively spliced ALLI-AF4 transcripts and absence of minimal residual disease during complete remission. Blood 84: 3835PubMedGoogle Scholar
  35. 35.
    Cimino G, Elia L, Rivolta A, Rap anotti MC, Rossi V, Alimena G, Annino L, Canaani E, Lo Coco F, Biondi A (1996) Clinical relevance of residual disease monitoring by polymerase chain reaction in patients with ALL-1/AF-4 positive acute lymphoblastic leukemia. Br J Haematol 92: 659PubMedCrossRefGoogle Scholar
  36. 36.
    Ida K, Taki T, Bessho F, Kobayashi M, Taira F, Hanada R, Yamamoto K, Okimoto Y, Seto M, Ueda R, Hayashi Y (1997) Detection of chimeric mRNAs by reverse transcriptase-polymerase chain reaction for diagnosis and monitoring of acute leukemias with 11g23 abnormalities. Med Pediatr Oncol 28: 325PubMedCrossRefGoogle Scholar
  37. 37.
    Schardt C, Ottmann OG, Hoelzer D, Ganser A (1992) Acute lymphoblastic leukemia with the t(4;11) translocation: combined cytogenetic, immunological and molecular genetic analysis. Leukemia 6: 370PubMedGoogle Scholar
  38. 38.
    Schoch C, Rieder H, Freund M, Hoelzer D, Riehm H, Fonatsch C (1995) Twenty-three cases of acute lymphoblastic leukemia with translocation t(4;11) (q21;q23): the implication of additional chromosomal aberrations. Ann Hematol 70: 195PubMedCrossRefGoogle Scholar
  39. 39.
    Pui C-H, Carroll A, Raimondi S, Shuster J, Crist W, Pullen J (1994) Childhood acute lymphoblastic leukemia with the t(4;11) (q21;q23): an update (letter). Blood 83: 2384PubMedGoogle Scholar
  40. 40.
    Hoelzer D, Thiel E, Löffler H, Büchner T, Ganser A, Heil G, Koch P, Freund M, Diedrich H (1988) Prognostic factors in a multicenter study for treatment of acute lymphoblastic leukemia in adults. Blood 71: 123PubMedGoogle Scholar
  41. 41.
    Boucheix C, David B, Sebban C, Racadot E, Bene MC, Bernard A, Campos L, Jouault H, Sigaux F, Lepage E, Hervé P, Fiere D (1994) Immunophenotype of adult acute lymphoblastic leukemia, clinical parameters, and outcome: An analysis of a prospective trial including 562 tested patients (LALA87]. Blood 84: 1603PubMedGoogle Scholar
  42. 42.
    Pui C-H, Hancock ML, Crist WM (1991) Prognosis in children with the t(4;11)(q21;q23) acute leukemia (response to a letter). Blood 78: 2472Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • H. Martin
    • 1
  • N. Goekburget
    • 1
  • J. Atta
    • 1
  • W.-D. Ludwig
    • 2
  • D. Hoelzer
    • 1
  1. 1.Medizinische Klinik IIIKlinikum der Johann Wolfgang Goethe Universität FrankfurtFrankfurtGermany
  2. 2.Robert Rössle-KlinikUK Rudolf VirchowGermany

Personalised recommendations