Role of Cyclin-Dependent Kinases and Their Inhibitors in Cellular Differentiation and Development

  • S. P. Chellappan
  • A. Giordano
  • P. B. Fisher
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 227)


The proliferation of normal cells is regulated by a combination of stimulatory and inhibitory factors that can respond to external signals in a coordinated manner (MacLachlan et al. 1995; Grana and Reddy 1995; Paggi et al. 1996). Various mitogens, growth factors, cytokines, and a host of other agents can perturb the cell cycle machinery eliciting proliferation, differentiation, or apoptosis (Reed et al. 1994; Reddy 1994). Any permanent alteration of the cell cycle-regulatory mechanisms can lead to abnormal proliferation, resulting in neoplasia (Blshor 1987, 1991; Morgan 1992). Such a situation can result following the inactivation of various tumor suppressor proteins, such as Rb and its family members and p53 (Marshall 1991; Cobrinik et al. 1992; Hollingsworth et al. 1993; Ewen 1994; Hooper 1994; Picksley and Lane 1994; Weinberg 1995; Giordano and Kaiser 1996), or by the dominant activation of positive-acting components of the cell cycle machinery, such as the cyclins and cyclin-dependent kinases (CDK) or proto-oncogenes (Pines 1995a, b; Kamb 1995; Bates and Peters 1995).


Transform Growth Factor Proliferate Cell Nuclear Antigen Cyclin Dependent Kinase Terminal Differentiation Mouse Embryo Fibroblast 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • S. P. Chellappan
    • 1
  • A. Giordano
    • 3
  • P. B. Fisher
    • 1
    • 2
  1. 1.Department of Pathology, Herbert Irving Comprehensive Cancer CenterCollege of Physicians and Surgeons of Columbia UniversityNew YorkUSA
  2. 2.Department of Urology, Herbert Irving Comprehensive Cancer CenterCollege of Physicians and Surgeons of Columbia UniversityNew YorkUSA
  3. 3.Department of Pathology, Anatomy and Cell Biology, Kimmel Cancer InstituteThomas Jefferson University, Sbarro Institute for Cancer Research and Molecular MedicinePhiladelphiaUSA

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