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Role of Cyclin-Dependent Kinases and Their Inhibitors in Cellular Differentiation and Development

  • Chapter
Cyclin Dependent Kinase (CDK) Inhibitors

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 227))

Abstract

The proliferation of normal cells is regulated by a combination of stimulatory and inhibitory factors that can respond to external signals in a coordinated manner (MacLachlan et al. 1995; Grana and Reddy 1995; Paggi et al. 1996). Various mitogens, growth factors, cytokines, and a host of other agents can perturb the cell cycle machinery eliciting proliferation, differentiation, or apoptosis (Reed et al. 1994; Reddy 1994). Any permanent alteration of the cell cycle-regulatory mechanisms can lead to abnormal proliferation, resulting in neoplasia (Blshor 1987, 1991; Morgan 1992). Such a situation can result following the inactivation of various tumor suppressor proteins, such as Rb and its family members and p53 (Marshall 1991; Cobrinik et al. 1992; Hollingsworth et al. 1993; Ewen 1994; Hooper 1994; Picksley and Lane 1994; Weinberg 1995; Giordano and Kaiser 1996), or by the dominant activation of positive-acting components of the cell cycle machinery, such as the cyclins and cyclin-dependent kinases (CDK) or proto-oncogenes (Pines 1995a, b; Kamb 1995; Bates and Peters 1995).

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References

  • Andres V, Walsh K (1996) Myogenin expression, cell cycle withdrawal and phenotypic differentiation are temporally separable events that precede cell fusion upon myogenesis. J Cell Biol 132: 657–666

    Article  PubMed  CAS  Google Scholar 

  • Aprelikova O, Xiong Y, Liu ET (1995) Both p16 and p21 families of cyclin-dependent kinase ( CDK) inhibitors block the phosphorylation of cyclin-dependent kinases by the CDK-activating kinase. J Biol Chem 1270: 18195–18197

    Google Scholar 

  • Bates S, Peters G (1995) Cyclin DI as a cellular proto-oncogene. Semin Cancer Biol 6: 73–82

    Article  PubMed  CAS  Google Scholar 

  • Benezra R, Davis RL, Lockshon D, Turner DL, Weintraub H (1990) The protein Id: a negative regulator of helix-loop-helix DNA binding proteins. Cell 61: 49–59

    Article  PubMed  CAS  Google Scholar 

  • Biggs JR, Kraft AS (1995) Inhibitors of cyclin-dependent kinase and cancer. J Mol Med 75: 509–514

    Google Scholar 

  • Bishop JM (1987) The molecular genetics of cancer. Science 235: 305–311

    Article  PubMed  CAS  Google Scholar 

  • Bishop JM (1991) Molecular themes in oncogenesis. Cell 64: 235–248

    Article  PubMed  CAS  Google Scholar 

  • Breituran T. Delonick D, Collins S (1980) Induction of differentiation of the human promyelocytic leukemia cell line (HL-60) by retinoic acid. Proc Natl Acad Sci USA 77: 2936–2940

    Article  Google Scholar 

  • Brugarolas J, Chandrasekaran C, Gordon JI, Beach D, Jacks T, Hannon GJ (1995) Radiation-induced cell cycle arrest compromised by p21 deficiency. Nature 377: 552–557

    Article  PubMed  CAS  Google Scholar 

  • Bullrich F, MacLachlan TK, Sang N, Druck T, Veronese ML, Allen SL, Chiorazzi N, Koff A, Huebner K, Croce CM, Giordano A (1995) Chromosomal mapping of members of the cdc2 family of protein kinases, cdk3, cdk6. PISSLRE and PITALRE and a cdk inhibitor, p27Kipl, to regions involved in human cancer. Cancer Res 55: 1199–1205

    PubMed  CAS  Google Scholar 

  • Calautti E, Missero C, Stein PL, Ezzell RM, Dotto GP (1995) Fyn tyrosine kinase is involved in keratinocyte differentiation control. Genes Dev 9: 2279–2291

    Article  PubMed  CAS  Google Scholar 

  • Caruso M, Martelli F, Giordano A, Felsani A (1993) Regulation of MyoD gene transcription and protein function by the transforming domains of the adenovirus ElA oncoproteins. Oncogene 8: 267–278

    PubMed  CAS  Google Scholar 

  • Castresana JS, Rubi MP, Vazquez J, Idoate M, Sober AJ, Seizinger BR, Barnhill RL (1993) Lack of allelic deletion and point mutation as mechanisms of p53 activation in human malignant melanoma. Intl J Oncol 55: 562–565

    CAS  Google Scholar 

  • Chan FK, Zhang J, Cheng L, Shapiro DN, Winoto A (1995) Identification of human and mouse p19, anovel CDK4 and CDK6 inhibitor with homology to pl6ink4. Mol Cell Biol 15: 2682–2688

    PubMed  CAS  Google Scholar 

  • Chellappan SP (1994) The E2F transcription factor: role in cell cycle regulation and differentiation. Mol Cell Diff 2 (3): 201–220

    CAS  Google Scholar 

  • Chen J, Jackson PK, Kireschner MW, Dotta A (1995) Separate domains of p21 involved in the inhibition of Cdk kinase and PCNA. Nature 374: 386–388

    Article  PubMed  CAS  Google Scholar 

  • Chen X, Bargonetti J, Prives C (1995) p53, through p21 ( WAFI/CIPI), induces cyclin DI synthesis. Cancer Res 55: 4257–4263

    PubMed  CAS  Google Scholar 

  • Clark W (1991) Tumor progression and the nature of cancer. Br J Cancer 64: 631–644

    Article  PubMed  CAS  Google Scholar 

  • Clurman BE, Bruns G (1995) Cell cycle and cancer. J Natl Cancer Inst 87: 1499–1501

    Article  PubMed  CAS  Google Scholar 

  • Coats S, Flanagan WM, Nourse J, Roberts JM (1996) Requirement of p27Kip1 for restriction point control of the fibroblast cell cycle. Science 272: 877–880

    Article  PubMed  CAS  Google Scholar 

  • Cobrinik D, Dowdy SF, Hinds PW, Mittnacht S, Weinberg RA (1992) The retinoblastoma protein and the regulation of cell cycling. Trends Biochem Sci 17: 312–315

    Article  PubMed  CAS  Google Scholar 

  • Collins SJ (1987) The HL-60 promyelocytic leukemia cell line: proliferation, differentiation, and cellular oncogene expression. Blood 70: 1233–1244

    PubMed  CAS  Google Scholar 

  • Collins SJ, Ruscetti FW, Gallagher R, Gallo R (1978) Terminal differentiation of the human promyelocytic leukemia cells induced by dimethylsulfoxide and other polar compounds. Proc Natl Acad Sci USA 75: 2458–2462

    Article  PubMed  CAS  Google Scholar 

  • Coppola JA, Lewis BA, Cole MD (1990) Increased retinoblastoma gene expression is associated with late stages of differentiation in many different cell types. Oncogene 5: 1731–1733

    PubMed  CAS  Google Scholar 

  • De Bondt HL, Rosenblatt J, Jancarik J, Jones HD, Morgan DO, Kim SH (1993) Crystal structure of cyclin-dependent kinase 2. Nature 363: 595–602

    Article  PubMed  Google Scholar 

  • Del Sal G, Murphy M, Ruaro EM, Lazarevic D, Levine AJ, Schneider C (1996) Cyclin D1 and p21 /wafl are both involved in p53 growth suppression. Oncogene 12: 177–185

    PubMed  Google Scholar 

  • Desai D, Wessling HC, Fisher RP, Morgan DO (1995) Effects of phosphorylation by CAK on cyclin binding by CDC2 and CDK2. Mol Cell Biol 15: 345–350

    PubMed  CAS  Google Scholar 

  • Deng C, Zhang P, Harper JW, Elledge SJ, Leder P (1995) Mice lacking p21c1Pi/WAF1 undergo normal development, but are defective in GI checkpoint control. Cell 82: 675–684

    Article  PubMed  CAS  Google Scholar 

  • DiGiuseppe JA, Redstone MS, Yeo CJ, Kern SE, Hruban RH (1995) p53-independent expression of the cyclin-dependent kinase inhibitor p21 in pacreatic carcinoma. Am J Pathol 147: 884–888

    Google Scholar 

  • Donehower LA, Harvey M, Slagle BL, McArthur MJ, Montgomery CA Jr, Butel JS, Bradley A (1992) Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumors. Nature 356: 215–221

    Article  PubMed  CAS  Google Scholar 

  • Dover R, Wright NA (1991) The cell proliferation kinetics of the epidermis. In: Goldsmith LA (ed) Physiology, biochemistry, and molecular biology of the skin. Oxford University Press, New York, pp 239–265

    Google Scholar 

  • Dracopoli NC, Sam B, Fountain JW, Schartl M (1992) A homolog of the Xiphophorus melanoma-inducing locus Xmrk maps to 6q27 a region frequently involved in rearrangements and deletions in human melanomas. Abstr Am J Hum Genet 54: A51

    Google Scholar 

  • Dulie V, Kaufmann WK, Wilson SJ, Tlsty TD, Lees E, Harper JW, Elledge SJ, Reed SI (1994) p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced GI arrest. Cell 76: 1013–1023

    Google Scholar 

  • Duro D, Bernard O, Della Valle V, Berger R, Larsen CJ (1995) A new type of p16INK4/MTSI gene transcript expressed in B-cell malignancies. Oncogene 11: 21–29

    PubMed  CAS  Google Scholar 

  • Duro D, Bernard O, Della Valle V, Leblanc T, Berger R, Larsen CJ (1996) Inactivation of the PI6INK4/ MTSI gene by a chromosome translocation t(9;14)(p21–22;811) in an acute lymphoblastic leukemia of B-cell type. Cancer Res 56: 848–854

    PubMed  CAS  Google Scholar 

  • Elbendary A, Berchuck A, Davis P, Havrilesky L, Bast RC, Iglehart JD, Marks JR (1994) Transforming growth factor ßl can induce CIPI/WAFT expression independent of the p53 pathway in ovarian cancer cells. Cell Growth Diff 5: 1301–1307

    PubMed  CAS  Google Scholar 

  • EI-Deiry WS, Tokino T, Velculesco VE, Levy DB, Parsons R, Trent JM, Lin D, Mercer WE, Kinzler, KW, Vogelstein B (1993) WAFT, a potential mediator of p53 tumor suppression. Cell 75: 817–825

    Article  Google Scholar 

  • Elledge SJ, Harper JW (1994) Cdk inhibitors: on the threshold of checkpoints and development. Curr Opin Cell Biol 6: 847–852

    Article  PubMed  CAS  Google Scholar 

  • Ewen ME (1994) The cell cycle and the retinoblastoma protein family. Cancer Metastas Reviews 13: 45–66

    Article  CAS  Google Scholar 

  • Ewen ME, Sluss HK, Sherr CJ, Matsushime H, Kato J, Livingston DM (1993) Functional interactions of the retinoblastoma protein with mammalian D-type cyclins. Cell 73: 487–497

    Article  PubMed  CAS  Google Scholar 

  • Fero ML, Rivkin M, Tasch M, Porter P, Carow CE, Firpo E, Polyak K, Tsai LH, Broudy V, Perlmutter RM, Kaushansky K, Roberts JM (1996) A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kipl)-deficient mice. Cell 85: 733–744

    Article  PubMed  CAS  Google Scholar 

  • Filvaroff E, Stern DF, Dotto GP (1990) Tyrosine phosphorylation is an early and specific event involved in primary keratinocyte differentiation. Mol Cell Biol 10: 1164–1173

    PubMed  CAS  Google Scholar 

  • Firpo EJ, Koff A, Solomon MJ, Roberts JM (1994) Inactivation of cdk2 inhibitor during interleukin 2-induced proliferation of human T-lymphocytes. Mol Cell Biol 14: 4889–4901

    PubMed  CAS  Google Scholar 

  • Fisher PB, Schachter D, Abbott RE, Callaham MF, Huberman E (1984) Membrane lipid dynamics in human promyelocytic leukemia cells sensitive and resistant to 12-O-tetradecanoyl-phorbol-l3-acetate induction of differentiation. Cancer Res 44: 5550–5554

    PubMed  CAS  Google Scholar 

  • Fisher PB, Prignoli DR, Hermo H Jr, Weinstein IB, Pestka S (1985) Effects of combined treatment with interferon and mezerein on melanogenesis and growth in human melanoma cells. J Interferon Res 5: 11–22

    Article  PubMed  CAS  Google Scholar 

  • Fisher RP, Morgan DO (1994) A novel cyclin associates MO15/CDK7 to form the CDK-activating kinase. Cell 78: 713–724

    Article  PubMed  CAS  Google Scholar 

  • Flores-Rozas H, Kelman Z, Dean FB, Pan Z, Harper WJ, Elledge SJ, O’Donnell M, Hurwitz J (1994) Cdk- interacting protein 1 directly binds with proliferating cell nuclear antigen and inhibits DNA replication catalyzed by the DNA polymerase and holoenzyme. Proc Natl Acad Sci USA 91:8655–8659

    Article  PubMed  CAS  Google Scholar 

  • Fountain JW, Bale SJ, Housman DE, Dracopoli NC (1990) Genetics of melanoma. Cancer Sury 9: 645–671

    CAS  Google Scholar 

  • Freemerman AJ, Vrana JA, Tombes RM, Jiang H, Fisher PB, Chellappan SP, Grant S (1997) Effects of antisense p21 (WAF1/CIPI/MDA-6) expression on the induction of differentiation and drug-mediated apoptosis in human myeloid leukemia cells (HL-60). Leukemia 11: 504–513

    Article  PubMed  CAS  Google Scholar 

  • Galktionov K, Jesus C, Beach D (1995) Raf-1 interaction with Cdc25 phosphatase ties mitogenic signaling to cell cycle activation. Genes Dev 9: 1046–1058

    Article  Google Scholar 

  • Gautier J, Solomon M, Booher R, Bazan J, Kirshner M (1991) Cdc25 is a specific tyrosine phosphatase that directly activates p34cdc2. Cell 67: 197–211

    Article  PubMed  CAS  Google Scholar 

  • Giordano A, Kaiser H (1996) The retinoblastoma gene: its role in cell cycle and cancer. In Vivo, 10: 223–228

    Google Scholar 

  • Goldstein S (1990) Replicative senescence: the human fibroblast comes of age. Science 249: 1129–1133

    Article  PubMed  CAS  Google Scholar 

  • Gonzalez-Zulueta M, Bender CM, Yang AS, Nguyen T, Beart RW, Van Tornout JM (1995) Methylation of the 5’ CpG island of the p16/CDKN2 tumor suppressor gene in normal and transformed human tissues correlates with gene silencing. Cancer Res 55: 4531–4535

    PubMed  CAS  Google Scholar 

  • Grana X, Reddy EP (1995) Cell cycle control in mammalian cells: role of cyclins, cyclin dependent kinases (CDKs), growth suppressor genes and cyclin-dependent kinase inhibitors ( CKIs ). Oncogene 11: 211–219

    PubMed  CAS  Google Scholar 

  • Greenblatt MS, Bennett WP, Hollstein M, Harris CC (1994) Mutations in the p53 tumour suppressor gene: clues to cancer etiology and molecular pathogenesis. Cancer Res 54: 4855–4878

    PubMed  CAS  Google Scholar 

  • Gu W, Schneider JW, Condorelli G, Nadal-Ginard B (1993) Interaction of myogenic factors and the retinoblastoma protein mediates muscle cell commitment and differentiation. Cell 72: 309–324

    Article  PubMed  CAS  Google Scholar 

  • Gu Y, Rosenblatt J, Morgan DO (1992) Cell cycle regulation of CDK2 activity by phosphorylation of Thr160 and Tyr15. EMBO J 11. 3995–4005

    PubMed  CAS  Google Scholar 

  • Gu Y, Turck CW, Morgan DO (1993) Inhibition of CDK2 activity in vivo by an associated 20 K regulatory subunit. Nature 366: 707–710

    Article  PubMed  CAS  Google Scholar 

  • Guan K, Jenkins CW, Li Y. Nichols MA, Wu X, O’Keefe CL, Matera AG, Xiong Y (1994) Growth suppression by p18, a p16INK/MTSI and pl4INK4/MTS2-related CDK6 inhibitor, correlates with wild-type RB function. Genes Dev 8: 2939–2952

    Article  PubMed  CAS  Google Scholar 

  • Guan X, Meltzer PS, Can J, Trent, JM (1992) Rapid generation of region-specific genomic clones by chromosome microdissection: isolation of DNA from a region frequently deleted in malignant melanoma. Genomics 14: 680–684

    Article  PubMed  CAS  Google Scholar 

  • Guo K, Wang J, Andres V, Smith RC, Walsh K (1995) MyoD-induced expression of p2I inhibits cyclin- dependent kinase activity upon myocyte terminal differentiation. Mol Cell Biol 15: 3823–3829

    PubMed  CAS  Google Scholar 

  • Halevy O. Novitch BG, Spicer DB, Skapek SX, Rhee J, Hannon GJ, Beach D, Lassar AB (1995) Correlation of terminal cell cycle arrest of skeletal muscle with induction of p21 by MyoD. Science 267: 1018–1021

    Article  PubMed  CAS  Google Scholar 

  • Hall M, Bates S, Peters G (1995) Evidence for different modes of action of cyclin-dependent kinase inhibitors: pl5 and p16 bind to kinases, p21 and p27 bind to cyclins. Oncogene 11: 1581–1588

    PubMed  CAS  Google Scholar 

  • Hannon GJ, Beach D (1994) pl5INK4b is a potential effector of cell cycle arrest mediated by TGF13. Nature 371: 257–261

    Google Scholar 

  • Harper JW, Adami GR, Wei N, Keyomarsi K, Elledge Si (1993) The p21 CDK-interacting protein CIPI is a potential inhibitor of GI cyclin-dependent kinases. Cell 75: 805–816

    Article  PubMed  CAS  Google Scholar 

  • Hartwell LH, Kastan MB (1994) Cell cycle control and cancer. Science 266: 1821–1828

    Article  PubMed  CAS  Google Scholar 

  • Harvey M, McArthur MJ, Montgomery CA, Butel JS, Bradley A, Donehower LA (1994) Spontaneous and carcinogen-induced tumorigenesis in p53-deficient mice. Nature Genet 5: 225–229

    Article  Google Scholar 

  • Hebert J, Cayuela JM, Berkeley J, Sigaux F (1994) Candidate tumor-suppressor genes MTSI (p16INK4A) and MTS2 (p151NK4B) display frequent homozygous deletions in primary cells from T- but not from B-cell lineage acute lymphoblastic leukemias. Blood 84: 4038–4044

    PubMed  CAS  Google Scholar 

  • Hengst L, Reed SI (1996) Translational control of p27Kipl accumulation during the cell cycle. Science 271: 1861–1864

    Article  PubMed  CAS  Google Scholar 

  • Hennings H, Micahel D, Cheng C, Steinert P, Holbrook K, Yuspa SH (1980) Calcium regulation of growth and differentiation of mouse epidermal cells in culture. Cell 19: 245–254

    Article  PubMed  CAS  Google Scholar 

  • Hermeking H, Funk JO, Reichert M, Ellwart JW, Eick D (1995) Abrogation of p53-induced cell cycle arrest by c-Myc: evidence for an inhibitor of p21wAFr/CIPI /SDI Oncogene 11: 1409–1415

    CAS  Google Scholar 

  • Herlyn M (1990) Human melanoma: development and progression. Cancer Metastas Rev 9: 101–112

    Article  CAS  Google Scholar 

  • Hirai H, Roussel MF, Kato JY, Ashmun RA, Sherr CJ (1995) Novel INK4 proteins, p19 and pIll, are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6. Mol Cell Biol 15: 2672–2681

    PubMed  CAS  Google Scholar 

  • Hollenstein M, Sidransky D, Vogelstein B, Harris CC (1991) p53 mutations in human cancers. Science, 253: 49–53

    Google Scholar 

  • Hollingsworth RJ, Hensey CE, Lee WH (1993) Retinoblastoma protein and the cell cycle. Curr Opin Genet Dev 3: 55–62

    Article  PubMed  CAS  Google Scholar 

  • Hooper ML (1994) The role of the p53 and Rb-I genes in cancer, development and apoptosis. J Cell Sci Suppl 18: 13–17

    PubMed  CAS  Google Scholar 

  • Horowitz JM, Udvadia AJ, (1995) Regulation of transcription by the retinoblastoma (Rb) protein. Mol Cell Diff 3 (4): 275–314

    CAS  Google Scholar 

  • Huberman E, Callaham MF (1979) Induction of terminal differentiation in human promyeolcytic leukemia cells by tumor-promoting agents. Proc Natl Acad Sci USA 76: 1293–1297

    Article  PubMed  CAS  Google Scholar 

  • Hunter T, Pines J (1994) Cyclins and cancer II: cyclin D and CDK inhibitors come of age. Cell 79: 573–582

    Article  PubMed  CAS  Google Scholar 

  • Jacks T, Fazeli A, Schmitt EM, Bronson RY, Goodell MA, Weinberg RA (1992) Effects of an Rh mutation in the mouse. Nature 359: 295–300

    Article  PubMed  CAS  Google Scholar 

  • Jacks T, Remington L, Wiliams BO, Schmitt EM, Halachmi S, Bronson RT, Weinberg RA (1994) Tumor spectrum analysis in p53-mutant mice. Curr Biol 4: 1–7

    Article  PubMed  CAS  Google Scholar 

  • Jiang H. Fisher PB (1993) Use of a sensitive and efficient subtraction hybridization protocol for the identification of genes differentially regulated during the induction of differentiation in human melanoma cells. Mol Cell Diff 1 (3): 285–299

    CAS  Google Scholar 

  • Jiang H, Su Z-Z, Boyd J, Fisher PB (1993) Gene expression changes associated with reversible growth suppression and the induction of terminal differentiation in human melanoma cells. Mol Cell Dill 1 (1): 4l - 66

    Google Scholar 

  • Jiang H, Lin J, Fisher PB (1994a) A molecular definition of terminal cell differentiation in human melanoma cells. Mol Cell Diff 2 (3): 221–239

    CAS  Google Scholar 

  • Jiang H, Lin J, Su Z-Z, Collart FR, Huberman E, Fisher PB (1994b) Induction of differentiation in human promyelocytic HL-60 leukemia cells activates p21, WAFI/CIPI, expression in the absence of p53. Oncogene 9: 3389–3396

    Google Scholar 

  • Jiang H, Lin JJ, Su Z-Z, Goldstein NI, Fisher PB (1995a) Subtraction hybridization identifies a novel melanoma differentiation associated gene, mda-7, modulated during human melanoma differentiation, growth and progression. Oncogene 11: 2477–2486

    PubMed  CAS  Google Scholar 

  • Jiang H, Lin J, Su Z-Z, Herlyn M, Kerbel RS, Weissman BE, Welch DR, Fisher PB, (1995b) The melanoma differentiation associated gene mda-6, which encodes the cyclin-dependent kinase inhibitor p21, is differentially expressed during growth, differentiation and progression in human melanoma cells. Oncogene 10: 1855–1864

    PubMed  CAS  Google Scholar 

  • Jiang H, Lin J, Young S-M, Goldstein NI, Waxman S, Davilla V, Chellappan SP, Fisher PB (1995e) Cell cycle gene expression and E2F transcription factor complexes in human melanoma cells induced to terminally differentiate. Oncogene 11: 1179–1189

    PubMed  CAS  Google Scholar 

  • Jiang H, Lin J, Su Z-Z, Fisher PB (1996a) The melanoma differentiation associated gene-6 (mda-6), which encodes the cyclin-dependent kinase inhibitor p21, may function as a negative regulator of human melanoma growth and progression. Mol Cell Diff 4 (1): 67–89

    CAS  Google Scholar 

  • Jiang H, Su Z-Z, Lin JJ, Goldstein NI, Young CSH, Fisher PB (1996b) The melanoma differentiation associated gene mda-7 suppresses cancer cell growth. Proc Natl Acad Sci USA 93: 9160–9165

    Article  PubMed  CAS  Google Scholar 

  • Jinno S, Suto K, Nagata A, Igarashi M, Kanaoka Y, Nojima H, Okayama H (1994) Cdc25A is a novel phosphatase functioning early in the cell cycle. EMBO J 13: 1549–1556

    PubMed  CAS  Google Scholar 

  • Kacker RK, Giovanella BC, Pathak S (1990) Consistent karyotypic abnormalities in human malignant melanomas. Anticancer Res 10: 859–872

    PubMed  CAS  Google Scholar 

  • Kamb A (1995) Cell-cycle regulators and cancer. Trends Genet 11: 136–140

    Article  PubMed  CAS  Google Scholar 

  • Kamb A, Gruis NA, Weaver-Feldhaus J, Liu Q, Harshman K, Tavtigian SV, Stockert E, Day RS III, Johnson BE, Skolnick MH (1994) A cell cycle regulator involved in genesis of many tumor types. Science 264: 436–440

    Article  PubMed  CAS  Google Scholar 

  • Kato J, Matsushime H, Hiebert SW, Ewen ME, Sherr CJ (1993) Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4. Genes Dev 7: 331–342

    Article  PubMed  CAS  Google Scholar 

  • Kato JY, Matsuoka M, Polyak K, Massague J, Sherr CJ (1994a) Cyclic AMP-induced GI phase arrest mediated by an inhibitor (p27Kipl) of cyclin-dependent kinase 4 activation. Cell 79: 487–496

    Article  PubMed  CAS  Google Scholar 

  • Kato JY, Matsuoka M, Strom DK, Sherr CJ (1994b) Regulation of cyclin D-dependent kinase 4 (cdk4)–by cdk4-activating kinase. Mol Cell Biol 14: 2713–2721

    PubMed  CAS  Google Scholar 

  • Kerbel RS (1990) Growth dominance and the metastatic cancer cell: cellular and molecular aspects. Adv Cancer Res 55: 87–132

    Article  PubMed  CAS  Google Scholar 

  • Kiyokawa H, Kineman RD, Manova-Todorova KO, Soares VC, Hoffman ES, Ono M, Khanam D, Hayday AC, Frohman LA, Koff A (1996) Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27(Kip1). Cell 85: 721–732

    Article  PubMed  CAS  Google Scholar 

  • Kobayashi H, Man S, MacDougall JR, Graham CH, Lu C, Kerbel RS (1994) Variant sublines of early-stage human melanomas selected for tumorigenicity in nude mice express a multicytokine-resistant phenotype. Am J Pathol 144: 776–786

    PubMed  CAS  Google Scholar 

  • Koff A, Ohtuski M, Polyak K, Roberts JM, Massague J (1993) Negative regulation of GI in mammalian cells: Inhibition of cyclin E-dependent kinase by TGFß. Science 260: 536–539

    Google Scholar 

  • Koh J, Enders GH, Dynlacht BD, Harlow E (1995) Tumour-derived p16 alleles encoding proteins defective in cell-cycle inhibition. Nature 375: 506–510

    Article  PubMed  CAS  Google Scholar 

  • Laiho M, DeCaprio J, Ludlow J, Livingston DM, Massague J (1990) Growth suppression by TGFß linked to suppression of retinoblastoma protein phosphorylation. Cell 62: 175–185

    Article  PubMed  CAS  Google Scholar 

  • Lassar AB, Skapek SX, Novitch B (1994) Regulatory mechanisms that coordinate skeletal muscle differentiation and cell cycle withdrawal. Curr Opin Cell Biol 6: 788–794

    Article  PubMed  CAS  Google Scholar 

  • Lee EY-HP, Chang CY, Hu N, Wang Y-CJ, Lai C-C, Herrup K, Lee WH, Bradley A (1992) Mice deficient for Rb are nonviable and show defects in neurogenesis and hematopoiesis. Nature 359: 288–294

    Article  PubMed  CAS  Google Scholar 

  • Lee MHJ, Reynisdottir I, Massague J (1995) Cloning of p57KIP2, a cyclin-dependent kinase inhibitor with unique domain structure and tissue distribution. Genes Dev 9: 639–649

    Article  PubMed  CAS  Google Scholar 

  • Lee MH, Nikolic M, Baptista CA, Lai E, Tsai LH, Massague J (1996) The brain-specific activator p35 allows CdkS to escape inhibition by p27KIPI in neurons. Proc Natl Acad Sci USA 93: 3259–3263

    Article  PubMed  CAS  Google Scholar 

  • Li R, Waga S, Hannon GJ, Beach D, Stillman B (1994) Differential effects by the p21 CDK inhibitor on PCNA-dependent DNA replication and repair. Nature 371: 534–537

    Article  PubMed  CAS  Google Scholar 

  • Li S, MacLachlan TK, De Luca A, Claudio PP, Condorelli G, Giordano A (1995) The cdc-2-related PISSLRE, is essential for cell growth and acts in G2 phase of the cell cycle. Cancer Res 55: 3992–3996

    PubMed  CAS  Google Scholar 

  • Li Y, Jenkins CW, Nichols MA, Xiong Y (1994) Cell cycle expression and p53 regulation of the cyclindependent kinase inhibitor p21. Oncogene 9: 2261–2268

    PubMed  CAS  Google Scholar 

  • Liotta LA, Steeg PG, Stetler-Stevenson WG (1991) Cancer metastasis and angiogenesis: an imbalance of positive and negative regulation. Cell 64: 327–336

    Article  PubMed  CAS  Google Scholar 

  • Liu M, Lee M-H, Cohen M, Bommakanti M, Freedman LP (1996) Transcriptional activation of the Cdk inhibitor p21 by vitamin D3 leads to the induced differentiation of the myelomonocytic cell line U937. Genes Dev 10: 142–153

    Article  PubMed  CAS  Google Scholar 

  • Loganzo F Jr, Nabeya Y, Maslak P, Albino AP (1994) Stabilization of p53 protein is a critical response to UV radiation in human melanocytes: implications for melanoma development. Mol Cell Diff 2 (1): 23–43

    CAS  Google Scholar 

  • Lotem J, Sachs L (1979) Regulation of normal differentiation in mouse and human myeloid leukemic cells by phorbol esters and the mechanism of tumor promotion. Proc Natl Acad Sci USA 76: 5158–5162

    Article  PubMed  CAS  Google Scholar 

  • Lu C, Kerbel RS (1994) Cytokines, growth factors and the loss of negative growth controls in the progression of human cutaneous malignant melanoma. Curr Opin Oncol 6: 212–220

    Article  PubMed  CAS  Google Scholar 

  • Lukas J, Parry D, Aagaard L, Mann DJ, Bartkova J, Strauss M, Peters G, Bartek J (1995) Retino-blastoma-protein-dependent cell-cycle inhibition by the tumour suppressor p16. Nature 375: 503–506

    Article  PubMed  CAS  Google Scholar 

  • Luo Y, Hurwitz J, Massague, J (1995) Cell-cycle inhibition by independent CDK and PCNA binding domains in p21Kip1. Nature 375: 159–161

    Article  PubMed  CAS  Google Scholar 

  • MacDougall JR, Kobayashi H, Kerbel RS (1993) Responsiveness of normal/dysplastic melanocytes and melanoma cells from different lesional stages of disease progression to the growth inhibitory effects of TGF-ß. Mol Cell Diff 1 (1): 21–40

    CAS  Google Scholar 

  • MacLachlan TK, Sang N, Giordano A (1995) Cyclins, cyclin-dependent kinases and Cdk inhibitors: implications in cell cycle control and cancer. Crit Rev Eukaryot Gene Express 5 (2): 127–156

    CAS  Google Scholar 

  • Macleod FF, Sherry N, Hannon G, Beach D, Tokino T, Kinzler K, Vogelstein B, Jacks T (1995) p53-dependent and independent expression of p21 during cell growth, differentiation and DNA damage. Genes Dev 9: 935–944

    Google Scholar 

  • MacJohnson DD, Vojta PJ, Barrett JC, Noda A, Pereira-Smith OM, Smith JR (1994) Evidence for a p53-independent pathway for upregulation of SDI1/CIPI/WAF1/p21 RNA in human cells. Mol Carcinog 11: 59–64

    Article  Google Scholar 

  • Mal A, Poon RY, Howe PH, Toyoshima H, Hunter T, Harter ML (1996) Inactivation of p27Kipl by the viral EIA oncoprotein in TGFbeta-treated cells. Nature 380: 262–265

    Article  PubMed  CAS  Google Scholar 

  • Mangelsdorf DJ, Pike JW, Haussier MR (1984) I25-dihydroxyvitamin D3-induced differentiation in a human promyelocytic leukemia cell line (HL-60): receptor-mediated maturation to macrophage-like cells. J Cell Biol 98: 391–398

    Article  PubMed  CAS  Google Scholar 

  • Massague J, Polyak K (1995) Mammalian antiproliferative signals and their targets. Curr Opin Genet Dev 5: 91–96

    Article  PubMed  CAS  Google Scholar 

  • Marshall CJ (1991) Tumor suppressor genes. Cell 64: 313–326

    Article  PubMed  CAS  Google Scholar 

  • Matsuoka M, Kato JY, Fisher RP, Morgan DO, Sherr CJ (1994) Activation of cyclin-dependent kinase 4 (cdk4) by mouse MO15-associated kinase. Mol Cell Biol 14: 7265–7275

    PubMed  CAS  Google Scholar 

  • Matsuoka S, Edwards MC, Bai C, Parker S, Zhang P, Baldini A, Harper JW, Elledge SJ (1995) p57KIP2, a structurally distinct member of the p21CIP1 Cdk inhibitor family, is a candidate tumor suppressor gene. Genes Dev 9(6):650–662

    Article  PubMed  CAS  Google Scholar 

  • Matsushime H, Roussel M, Ashmun R, Sherr CJ (1991) Colony stimulating factor 1 regulates novel cyclins during the GI phase of the cell cycle. Cell 65: 701–713

    Article  PubMed  CAS  Google Scholar 

  • Matsushime H, Quelle DE, Shurtleff SA, Shibuya M, Sherr CJ, Kato JY (1994) D-type cyclin-dependent kinase activity in mammalian cells. Mol Cell Biol 14: 2066–2076

    PubMed  CAS  Google Scholar 

  • McCarthy DM, San Miguel J, Freake HC, Green PM, Zola H, Catowsky D, Goldman.1 (1983) 1,25dihydroxyvitamin D3 inhibits the proliferation of human promyelocytic leukemia cell line (HL-60) cells and induces monocyte-macrophage differentiation in HL-60 and normal bone marrow cells. Leuk Res 7: 51–55

    Google Scholar 

  • Michieli P, Chedid M, Lin D, Pierce JH, Mercer WE, Givol D (1994) Induction of WAFT/CIPI by a p53-independent pathway. Cancer Res 54: 3391–3395

    PubMed  CAS  Google Scholar 

  • Miele ME, Robertson G, Lee J-H, Coleman A, McGary CT, Fisher PB, Lugo TG, Welch DR (1996) Metastasis suppressed, but tumorigenicity and local invasiveness unaffected, in the human melanoma cell line MelJuSo after introduction of human chromosome 1 or 6. Mol Carcinog 15: 284–299

    Article  PubMed  CAS  Google Scholar 

  • Missero C, Calautti E, Eckner R, Chin J, Tsai LH, Livingston DM, Dotto PG (1995) Involvement of the cell-cycle inhibitor Cipl/Wafl and the EIA-associated p300 protein in terminal differentiation. Proc Natl Acad Sci USA 92: 5451–5455

    Article  PubMed  CAS  Google Scholar 

  • Missero M, Dotto GP (1996) p21wAFUCIPI and terminal differentiation control of normal epithelia. Mol Cell Diff 4(1):1–16

    CAS  Google Scholar 

  • Miyaura C, Abe E, Kuribayashi T, Tanaka H, Konno K, Nishii Y, Suda T (1981) P25-dihydroxyvitaroin D; induces differentiation of human myeloid leukemia cells. Biochcm Bipophys Res Commun 102: 937–943

    Article  CAS  Google Scholar 

  • Montano X, Shamsher M, Whitehead P, Dawson K, Newton J (1994) Analysis of p53 in human cutaneous melanoma cell lines. Oncogene 9: 1455–1459

    PubMed  CAS  Google Scholar 

  • Morgan DO (1992) Cell cycle control in normal and neoplastic cells. Curr Opin Genet Dev 2:33–37 Morgan DO (1995) Principles of CDK regulation. Nature 374: 131–134

    Google Scholar 

  • Morgan DO (1996) Under arrest at atomic resolution. Nature 382: 295–296

    Article  PubMed  CAS  Google Scholar 

  • Morgan DO, De Bondt HL (1994) Protein kinase regulation: insights from crystal structure analysis. Curr Opin Cell Biol 6 (2): 239–246

    Article  PubMed  CAS  Google Scholar 

  • Murao S-I, Gemmell MA, Callahan MF, Anderson NL, Huberman E (1983) Control of macrophage cell differentiation in human promyelocytic HL-60 leukemia cells by 1,25-dihydroxyvitamin D3 and phorbol-l2-myristate-13-acetate. Cancer Res 43: 4989–4996

    PubMed  CAS  Google Scholar 

  • Nakanishi M, Robetorge RS, Adami GR, Pereira-Smith OM, Smith JR (1995) Identification of the active region of the DNA synthesis inhibitory gene p21IIPI/wAF. EMBO J 14: 555–563

    PubMed  CAS  Google Scholar 

  • Nakayama K, Ishida N, Shirane M, Inomata A, Inoue T, Shishido N, Horii I, Loh DY, Nakayama K (1996) Mice lacking p27(Kipl) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors. Cell 85: 707–720

    Article  PubMed  CAS  Google Scholar 

  • Nevins JR (1992) E2F: a link between the Rb tumor suppressor protein and viral oncoproteins. Science 258: 424–429

    Article  PubMed  CAS  Google Scholar 

  • Nobori T, Miura K, Wu DJ, Lois A, Takabayashi K, Carson DA (1994) Deletions of the cyclin dependent kinase 4 inhibitor gene in multiple human cancers. Nature 368: 753–756

    Article  PubMed  CAS  Google Scholar 

  • Noda A, Ning Y, Venable SF, Pereira-Smith OM, Smith JR (1994) Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen. Exp Cell Res 211: 90–98

    Article  PubMed  CAS  Google Scholar 

  • Nourse J, Firpo E, Flanagan WM, Coats S, Polyak K, Lee MH, Massague J, Crabtree J, Roberts JM (1994) Interleukin 2-mediated elimination of p27KIPl cyclin-dependent kinase inhibitor prevented by rapamycin. Nature 372: 570–573

    Article  PubMed  CAS  Google Scholar 

  • Okamoto A, Demetrick DJ, Spillare EA, Hagiwara K, Hussain SP, Bennett WP, Forrester K, Gerwin B, Serrano M, Beach DH, Harris CC (1994) Mutations and altered expression p16INK4 in human cancer. Proc Natl Acad Sci USA 91: 11045–11049

    Article  PubMed  CAS  Google Scholar 

  • Okuda T, Hirai H, Valentine VA, Shurtleff SA, Kidd Vi, Lahti JM, Sherr CJ, Downing JR (1995a) Molecular cloning, expression pattern, and chromosomal localization of human CDKN2D/INK4d, an inhibitor of cyclin D-dependent kinases. Genomics 29: 623–630

    Article  PubMed  CAS  Google Scholar 

  • Okuda T, Shurtleff SA, Valentine MB, Raimondi SC, Head DR, Behm F, Curcio-Brint AM, Liu Q, Pui C-H, Sherr CJ, Beach D, Look AT, Downing JR (1995b) Frequent deletion of pl6INK4a/MTSI and pl5lNK4b/MTS2 in pediatric acute lymphoblastic leukemia. Blood 85: 2321–2330

    PubMed  CAS  Google Scholar 

  • Olson EN, Klein WH (1994) bHLH factors in muscle development: dead lines and commitments, what to leave in and what to leave out. Genes Dev 8: 1–8

    Google Scholar 

  • Pagano M, Tam SW, Theodoras AM, Beer-Romero P, Del Sal G, Chau V, Yew PR, Draetta GF, Rolfe M (1995) Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27. Science 269: 682–685

    Article  PubMed  CAS  Google Scholar 

  • Paggi MG, Baldi A, Bonetto F, Giordano A (1996) The retinoblastoma protein family in cell cycle and cancer. J Cell Biochem 62: 418–430

    Article  PubMed  CAS  Google Scholar 

  • Parker SB, Eichele G, Zhang P, Rawls A, Sands AT, Bradley A, Olson EN, Harper JW, Elledge SJ (1995) p53-independent expression of p21cIPI in muscle and other terminally differentiating cells. Science 267: 1024–1027

    Google Scholar 

  • Parry D, Bates S, Mann DJ, Peters G (1995) Lack of cyclin D-Cdk complexes in Rh-negative cells correlates with high levels of p16INK4/MTSI tumour suppressor gene product. EMBO J 14 (3): 503–511

    PubMed  CAS  Google Scholar 

  • Pathak S, Drwinga HL, Hsu TC (1983) Involvement of chromosome 6 in rearrangements in human malignant melanoma. Cancer Genet Cytotgenet 36: 573–579

    Article  CAS  Google Scholar 

  • Picksley SM, Lane DP (1994) p53 and Rb: their cellular roles. Curr Opin Cell Biol 6: 853–858

    Google Scholar 

  • Pientenpol JA, Bohlander SK, Sato Y, Papadopoulos N, Liu B, Friedman C, Trask III, Roberts JM, Kinzler KW, Rowley JD, Vogelstein B (1995) Assignment of the human p27Kipl gene to 12p13 and its analysis in leukemias. Cancer Res 55: 1206–1210

    Google Scholar 

  • Pines J (1995a) Cyclins and cyclin-dependent kinases: theme and variations. Adv Cancer Res 66:181–212

    Article  PubMed  CAS  Google Scholar 

  • Pines J (1995b) Cyclins, CDKs and cancer. Semin Cancer Biol 6: 63–72

    Article  PubMed  CAS  Google Scholar 

  • Pines J (1995c) Cyclins and cyclin-dependent kinases: a biochemical view. Biochem J 308: 697–711

    PubMed  CAS  Google Scholar 

  • Polyak K, Kato JY, Solomon MJ, Sherr CJ, Massague J, Roberts JM, Koff A (1994a) p27KipI, a cyclin- Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest. Genes Dev 8: 9–22

    Google Scholar 

  • Polyak K, Lee M-H, Erdjument-Bromage H, Koff A, Roberts JM, Tempst P, Massague,l (1994b) Cloning of p27KIPI, a cyclin-dependent-kinase inhibitior and a potential mediator of extracellular antimitogenic signals. Cell 78: 59–76

    CAS  Google Scholar 

  • Ponce-Castaneda MV, Lee MH, Latres E, Polyack K, Lacombe L, Montgomery K, Mathew S, Krauter K, Massague J, Cordon-Cardo C (1995) p27: chromosomal mapping to 12p12 and absence of mutations in human tumors. Cancer Res 55: 1211–1214

    Google Scholar 

  • Poon RY, Hunter T (1995) Cell regulation. Innocent bystanders or chosen collaborators? Curr Biol 5: 1243–1247

    Article  PubMed  CAS  Google Scholar 

  • Poon RY, Yamashita K, Adamczewski JP, Hunt T, Shuttleworth J (1993) The cdc2-related protein p40MOI5 is the catalytic subunit of a protein kinase that can activate cdc2. EMBO J 12(8):3123–3132

    PubMed  CAS  Google Scholar 

  • Poon RY, Toyoshima H, Hunter T (1995) Redistribution of the CDK inhibitor p27 between different cyclin-CDK complexes in the mouse fibroblast cell cycle and in cells arrested with lovastatin or ultraviolet irradiation. Mol Biol Cell 6: 1197–1213

    PubMed  CAS  Google Scholar 

  • Quelle DE, Zindy F, Ashmun RA, Sherr CJ (1995a) Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest. Cell 83: 993–1000

    Article  PubMed  CAS  Google Scholar 

  • Quelle DE, Ashmun RA, Hannon GJ, Rehberger PA, Trono D, Richter KH, Walker C, Beach D, Sherr CJ, Serrano M (1995b) Cloning and characterization of murine p16INK4a and pI5INK4b genes. Oncogene 11: 635–645

    PubMed  CAS  Google Scholar 

  • Rao SS, Chu C, Kohtz DS (1994) Ectopic expression of cyclin Dl prevents activation of gene transcription by myogenic basic helix-loop-helix regulators. Mol Cell Biol 14: 5259–5267

    PubMed  CAS  Google Scholar 

  • Reddy GP (1994) Cell cycle: regulatory events in GI-S transition of mammalian cells. J Cell Biochem 54: 379–386

    Article  PubMed  CAS  Google Scholar 

  • Reed SI, Bailly E, Dulic V, Hengst L, Resnitzky D, Slingerland J (1994) GI control in mammalian cells. J Cell Sci Suppl 18: 69–73

    PubMed  CAS  Google Scholar 

  • Reynisdottir I, Polyak K, Iavarone A, Massague J (1995) Kip/Cil) and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-beta. Genes Dev 9: 1831–1845

    Article  PubMed  CAS  Google Scholar 

  • Robetorye RS, Nakanishi M, Venable SF, Pereira-Smith OM, Smith JR (1996) Regulation of p2lsd~i~c~n~w.~nh„d“-6 and expression of other cyclin-dependent kinase inhibitors in senescent cell. Mol Cell Diff4(1): 113–126

    Google Scholar 

  • Rovera G, Santoli D, Damsky C (1979) Human promyeolcytic leukemia cells in culture differentiate into macrophage-like cells when treated with a phorbol diester. Proc Natl Acad Sci USA 76: 2779–2783

    Article  PubMed  CAS  Google Scholar 

  • Russo AA, Jeffrey PD, Patten AK, Massague J, Pavletich NP (1996) Crystal structure of the p27Kipl cyclin-dependent-kinase inhibitor bound to the cyclin A-cdk2 complex. Nature 382: 325–331

    Article  PubMed  CAS  Google Scholar 

  • Sang N, Baldi A, Giordano A (1995) The roles of tumor suppressors pRb and p53 in cell proliferation and cancer. Mol Cell Diff 3 (1): 1–29

    CAS  Google Scholar 

  • Schneider JW, Gu W, Zhu L, Mandavi V, Nadal-Ginard B (1995) Reversal of terminal differentiation meidated by p107 in Rb-/- muscle cells. Science 264: 1467–1471

    Article  Google Scholar 

  • Schwaller J, Koeffler HP, Niklaus G, Loetscher P, Magd S, Fey MF, Tobler A (1995) Posttranscriptional stabilization underlies p53-independent induction of p21/WAFT/CIP1/SDI I in differentiating human leukemic cells. J Clin Invest 95: 973–979

    Article  PubMed  CAS  Google Scholar 

  • Serrano M, Hannon GJ, Beach D (1993) A new regulatory motif in cell cycle control causing specific inhibition of cyclinD-cdk4. Nature 366: 704–707

    Article  PubMed  CAS  Google Scholar 

  • Serrano M, Gomez-Lahoz E, DePinho RA, Beach D, Bar-Sagi D (1995) Inhibition of ras-induced proliferation and cellular transformation by pl6INK4. Science 267: 249–252

    Article  PubMed  CAS  Google Scholar 

  • Serrano M, Lee H, Chin L, Cordon-Cardo C, Beach D, DePinho RA (1996) Role of INK4a locus in tumor suppression and cell mortality. Cell 85: 27–37

    Article  PubMed  CAS  Google Scholar 

  • Sheikh MS, Li X-S, Chen J-C, Shao Z-M, Ordonez JV, Fontana JA (1994) Mechanisms of regulation of WAF1/CipI gene expression in human breast carcinoma: role of p53-dependent and independent signal transduction pathways. Oncogene 9: 3407–3415

    PubMed  CAS  Google Scholar 

  • Sherr CJ (1993) Mammalian GI cyclins. Cell 73: 1059–1065

    Article  PubMed  CAS  Google Scholar 

  • Sherr CJ (1994a) GI phase progression: cycling on cue. Cell 79: 551–555

    Article  PubMed  CAS  Google Scholar 

  • Sherr CJ (1994b) Growth-factor-regulated GI cyclins. Stem Cells 12[Suppl] 1: 47–55

    Google Scholar 

  • Sherr CJ (1995) D-type cyclins. Trends Biochem. Sci 20: 187–190

    CAS  Google Scholar 

  • Sherr CJ, Roberts JM (1995) Inhibitors of mammalian Gicyclin-dependent kinases. Genes Dev 9: 1149–1163

    Article  PubMed  CAS  Google Scholar 

  • Sherr CJ, Kato J, Quelle DE, Matsuoka M, Roussel MF (1994) D-type cyclins and their cyclin-dependent kinases: GI phase integrators of the mitogenic response. Cold Spring Harb Symp Quant Biol 59: 1 1–19

    Google Scholar 

  • Shiekhattar R, Mermelstein F, Fisher, RP, Drapkin R, Dynlacht B, Wessling HC, Morgan DO, Reinberg D (1995) Cdk-activating kinase complex is a component of human transcription factor TFIIH. Nature 374: 283–287

    Article  PubMed  CAS  Google Scholar 

  • Shivji MKK, Grey SJ, Strausfeld UP, Wood RD, Blow JJ (1994) CipI inhibits DNA replication but not PCNA-dependent nucleotide excision-repair. Curr Biol 4: 1062–1068

    Article  PubMed  CAS  Google Scholar 

  • Skapek SX, Rhee J, Spicer DB, Lassar AB (1995) Inhibition of myogenic differentiation in proliferating myoblasts by cyclin DI-dependent kinase. Science 267: 1022–1027

    Article  PubMed  CAS  Google Scholar 

  • Smith JR, Pereira-Smith OM (1996) Replicative senescence: implications for in vivo aging and tumor suppression. Science 273: 63–67

    Article  PubMed  CAS  Google Scholar 

  • Steinman RA, Hoffman B, Iro A, Guillouf C, Liebermann DA, El-Houseini ME (1994) Induction of p21 (WAFT/CIP1) during differentiation. Oncogene 9: 3389–3396

    PubMed  CAS  Google Scholar 

  • Stone S, Jiang P, Dayananth P, Tavtigian SV, Katcher H, Parry D, Peters G, Kamb A (1995) Complex structure and regulation of the PI6 (MTS1) locus. Cancer Res 55: 2988–2994

    PubMed  CAS  Google Scholar 

  • Su Z-Z, Austin VA, Zimmer SG, Fisher PB (1993) Defining the critical gene expression changes associated with expression and suppression of the tumorigenic and metastatic phenotype in Ha-rastransformed cloned rat embryo fibroblast cells. Oncogene 8: 1211–1219

    PubMed  CAS  Google Scholar 

  • Su Z-Z, Yemul S, Estabrook A, Zimmer SG, Friedman RM, Fisher PB (1995) Transcriptional switching model for the regulation of tumorigenesis and metastasis by the Ha-ras oncogene: transcriptional changes in the Ha-ras tumor suppressor gene lysyl oxidase. Intl J Oncology 7: 1279–1284

    CAS  Google Scholar 

  • Tam SW, Shay JW, Pagano M (1994) Differential expression and cell cycle regulation of the cyclin dependent kinase 4 inhibitior pI6INK4. Cancer Res 54: 5816–5820

    PubMed  CAS  Google Scholar 

  • Toyoshima H, Hunter T (1994) p27, a novel inhibitior of Gl-cyclin-cdk protein kinase activity is related to p21. Cell 78: 67–74

    Google Scholar 

  • Trent JM (1991) Cytogenetics of human malignant melanoma. Cancer Metastas Rev 10: 103–113

    Article  CAS  Google Scholar 

  • Trent JM, Stanbridge EJ, McBride HL, Meese EU, Casey G, Araujo DE, Witkowski CM, Nagle RB (1990) Tumorigenicity in human melanoma cell lines controlled by introduction of human chromosome 6. Science 247: 568–571

    Article  PubMed  CAS  Google Scholar 

  • lJeki K, Ono Y, Henson JW, Efird JT, von Deimling A, Louis DN (1996) CDKN2/p16 or RB alterations occur in the majority of glioblastomas and are inversely correlated. Cancer Res 56: 150–153

    Google Scholar 

  • Volkenandt M, Schlegel U, Manus DM, Albino AP (1991) Mutational analysis of the human p53 gene in malignant melanoma. Pigment Cell Res 4: 35–40

    Article  PubMed  CAS  Google Scholar 

  • Waga S, Hannon GJ, Beach D, Stillman B (1994) The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA. Nature 369: 574–578

    Article  PubMed  CAS  Google Scholar 

  • Walsch K, Guo K, Wang J, Andres V (1996) p21 Regulation and function during myogenesis. Mol Cell Diff 4(I):17–31

    CAS  Google Scholar 

  • Wang J, Walsh K (1996) Resistance to apoptosis conferred by Cdk inhibitors during myocyte differentiation. Science 273: 359–361

    Article  PubMed  CAS  Google Scholar 

  • Weinberg RA (1995) The retinoblastoma protein and cell cycle control. Cell 81: 323–330

    Article  PubMed  CAS  Google Scholar 

  • Weintraub H (1993) The MyoD family and myogenesis: redundancy, networks and thresholds. Cell 75: 1241–1244

    Article  PubMed  CAS  Google Scholar 

  • Welch DR, Rieber M (1996) Is p21 WAFT a suppressor of malignant melanoma metastasis? Mol Cell Diff 4(1):91–11l

    CAS  Google Scholar 

  • Welch DR, Bisi JE, Miller BE, Conaway D, Seftor EA, Gilmore LB, Seftor REB, Nakajima M, Hendrix MJC (1991) Characterization of a highly invasive and spontaneously metastatic human malignant melanoma cell line. Int J Cancer 47: 227–237

    Article  PubMed  CAS  Google Scholar 

  • Welch DR, Chen P, Miele ME, McGary CT, Bower JM, Weissman BE, Stanbridge EJ (1994) Microcellmediated transfer of chromosome 6 into metastatic human C8161 melanoma cells suppresses metastasis but does not inhibit tumorigenicity. Oncogene 9: 255–262

    PubMed  CAS  Google Scholar 

  • Whyte P (1995) The retinoblastoma protein and its relatives. Semin Cancer Biol 6: 83–90

    Article  PubMed  CAS  Google Scholar 

  • Williams BO, Schmitt, EM, Remington L, Bronson RT, Albert DM, Weinberg RA, Jacks T (1994a) Extensive contribution of Rb deficient cells to adult chimeric mice with limited histopathological consequences. EMBO J 13: 4251–4259

    PubMed  CAS  Google Scholar 

  • Williams BO, Remington L, Albert DM, Mukai S, Bronson RT, Jacks T (1994) Cooperative tumorigenic effects of germ-line mutations in Rb and p53. Nature Genet 7: 480–484

    Article  PubMed  CAS  Google Scholar 

  • Wu H, Wade M, Krall L, Grisham J, Xiong Y, Van Dyke T (1996) Targeted in vivo expression of the cyclin-dependent kinase inhibitor p21 halts hepatocyte cell-cycle progression, postnatal liver development, and regeneration. Genes Dev 10: 245–260

    Article  PubMed  CAS  Google Scholar 

  • Xiong Y, Zhang H, Beach D (1992) D-type cyclins associate with multiple protein kinases and the DNA replication and repair factor PCNA. Cell 71: 505–514

    Article  PubMed  CAS  Google Scholar 

  • Xiong Y, Hannon GJ, Zhang H, Casso D, Kobayashi R, Beach D (1993a) p21 is a universal inhibitor of cyclin kinases. Nature 366: 701–704

    Google Scholar 

  • Xiong Y, Zhang H, Beach D (1993b) Subunit rearrangement of the cyclin-dependent kinases is associated with cellular transformation. Genes Dev 7: 1572–1583

    Article  PubMed  CAS  Google Scholar 

  • Yang Z-Y, Perkins ND, Ohno O, Nabel EG, Nabel GJ (1995) The p21 cyclin-dependent kinase inhibitor suppresses tumorigenicity in vivo. Nature Med 1: 1052–1056

    Article  PubMed  CAS  Google Scholar 

  • Yuan W, Condorelli G, Caruso M, Felsani A, Giordano A (1996) Human p300 protein is a coactivator for the transcription factor MyoD. J Biol Chem 271: 9009–9013

    Article  PubMed  CAS  Google Scholar 

  • Zakut R, Givol D (1995) The tumor suppressor function of p21 is contained in its N-terminal half (`half-WAF’). Oncogene 11: 393–395

    PubMed  CAS  Google Scholar 

  • Zhang H, Xiong Y, Beach D (1993) Proliferating cell nuclear antigen and p21 are components of multiple cell cycle kinase complexes. Mol Biol Cell 4: 897–906

    PubMed  CAS  Google Scholar 

  • Zhang H, Hannon GJ, Beach D (1994) p21-containing cyclin kinases exist in both active and inactive states. Genes Dev 8: 1750–1758

    Article  PubMed  CAS  Google Scholar 

  • Zhang W, Grasso L, McClain CD, Gambel AM, Cham Y, Travali S, Deisseroth AB, Mercer WE (1995) p53-independent induction of WAFI/CIP] in human leukemia cells is correlated with growth arrest accompanying monocyte/macrophage differentiation. Cancer Res 55: 668–674

    PubMed  CAS  Google Scholar 

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  1. Department of Pathology, Herbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons of Columbia University, 630 West 168th St, New York, NY, 10032, USA

    S. P. Chellappan & P. B. Fisher

  2. Department of Urology, Herbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons of Columbia University, New York, NY, 10032, USA

    P. B. Fisher

  3. Department of Pathology, Anatomy and Cell Biology, Kimmel Cancer Institute, Thomas Jefferson University, Sbarro Institute for Cancer Research and Molecular Medicine, 233 South 10th Street, Philadelphia, PA, 19107, USA

    A. Giordano

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  1. Division of Oncovirology, Department of Molecular and Experimental Medicine, The Scripps Research Institute, SBR7, Rm. SR311, 10550 North Torrey Pines Road, 92037, La Jolla, CA, USA

    Peter K. Vogt Ph.D.

  2. Department of Molecular Medicine, MB-7, The Scripps Research Institute, 10550 North Torrey Pines Road, 92037, La Jolla, CA, USA

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Chellappan, S.P., Giordano, A., Fisher, P.B. (1998). Role of Cyclin-Dependent Kinases and Their Inhibitors in Cellular Differentiation and Development. In: Vogt, P.K., Reed, S.I. (eds) Cyclin Dependent Kinase (CDK) Inhibitors. Current Topics in Microbiology and Immunology, vol 227. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71941-7_4

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