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The INK4 Family of CDK Inhibitors

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Cyclin Dependent Kinase (CDK) Inhibitors

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 227))

Abstract

Decisions concerning the fate of a cell are intimately linked to the proliferative state of that cell. Proliferation of certain cell populations is required to maintain or repair tissues in an aging organism. However, this proliferation must be tightly regulated. Failure to control proliferation may interfere with differentiation, causing a cell to fail to achieve its fully determined state. Potentially more severe consequences could also ensue from uncontrolled cell division. When this is accompanied by a failure of programmed cell death, a cancerous tumor can result.

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Author notes

  1. A. Carnero

    Present address: Institute of Child Health, 30 Guilford Street, London, WC1N 1EH, UK

Authors and Affiliations

  1. Cold Spring Harbor Laboratory, P.O. BOX 100, Cold Spring Harbor, NY, 11724, USA

    A. Carnero & G. J. Hannon

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  1. A. Carnero
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  2. G. J. Hannon
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Editors and Affiliations

  1. Division of Oncovirology, Department of Molecular and Experimental Medicine, The Scripps Research Institute, SBR7, Rm. SR311, 10550 North Torrey Pines Road, 92037, La Jolla, CA, USA

    Peter K. Vogt Ph.D.

  2. Department of Molecular Medicine, MB-7, The Scripps Research Institute, 10550 North Torrey Pines Road, 92037, La Jolla, CA, USA

    Steven I. Reed Ph.D.

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© 1998 Springer-Verlag Berlin Heidelberg

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Carnero, A., Hannon, G.J. (1998). The INK4 Family of CDK Inhibitors. In: Vogt, P.K., Reed, S.I. (eds) Cyclin Dependent Kinase (CDK) Inhibitors. Current Topics in Microbiology and Immunology, vol 227. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71941-7_3

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  • DOI: https://doi.org/10.1007/978-3-642-71941-7_3

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-71943-1

  • Online ISBN: 978-3-642-71941-7

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