Effect of Gangliosides on Nerve Conduction Velocity During Diabetic Neuropathy in the Rat

  • W. Dimpfel
  • M. Spüler
  • H.-U. Tüllner
Conference paper
Part of the NATO ASI Series book series (volume 7)


Gangliosides, a class of glycosphingolipids, originally isolated from brain matter and described as substance X by Klenk (1), have been analyzed in detail since then and related to a number of biological functions (for review see 2,3). Among these functions a possible positive effect on neuronal degeneration has been proposed by several authors (4,5) and requires further evaluation with respect to the therapeutical potential of gangliosides in the course of neuropathies.


Neuroblastoma Cell Diabetic Neuropathy Neuronal Degeneration Nerve Conduction Velocity Compound Action Potential 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • W. Dimpfel
    • 1
  • M. Spüler
    • 1
  • H.-U. Tüllner
    • 1
  1. 1.Pro Science Private Research Institute GmbHLinden 2Federal Republic of Germany

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