Effect of Gangliosides on Nerve Conduction Velocity During Diabetic Neuropathy in the Rat
Gangliosides, a class of glycosphingolipids, originally isolated from brain matter and described as substance X by Klenk (1), have been analyzed in detail since then and related to a number of biological functions (for review see 2,3). Among these functions a possible positive effect on neuronal degeneration has been proposed by several authors (4,5) and requires further evaluation with respect to the therapeutical potential of gangliosides in the course of neuropathies.
KeywordsNeuroblastoma Cell Diabetic Neuropathy Neuronal Degeneration Nerve Conduction Velocity Compound Action Potential
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