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Effect of Gangliosides on Nerve Conduction Velocity During Diabetic Neuropathy in the Rat

  • W. Dimpfel
  • M. Spüler
  • H.-U. Tüllner
Conference paper
Part of the NATO ASI Series book series (volume 7)

Abstract

Gangliosides, a class of glycosphingolipids, originally isolated from brain matter and described as substance X by Klenk (1), have been analyzed in detail since then and related to a number of biological functions (for review see 2,3). Among these functions a possible positive effect on neuronal degeneration has been proposed by several authors (4,5) and requires further evaluation with respect to the therapeutical potential of gangliosides in the course of neuropathies.

Keywords

Neuroblastoma Cell Diabetic Neuropathy Neuronal Degeneration Nerve Conduction Velocity Compound Action Potential 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Klenk E (1939) Beiträge zur Chemie der Lipoidosen. Niemann-Picksche Krankheit und amaurotische Idiotie. Hoppe-Seylers Z Physiol Chem 262: 128–143CrossRefGoogle Scholar
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    Wiegandt H (1985) Gangliosides. In: Wiegandt H (ed) Glykolipids. Elsevier Science Publishers B. V. pp 199–260CrossRefGoogle Scholar
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    Ledeen R (1984) Biology of Gangliosides. J Neurosci Res 12: 147–159PubMedCrossRefGoogle Scholar
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    Norido F, Canella R, Zanoni R and Gorio A (1984) The development of diabetic neuropathy in the C57 BL/Ks (db/db) mouse and its treatment with gangliosides. Exp Neurol 83: 221–233PubMedGoogle Scholar
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    Gorio A, Aporti F, Di Gregorio F, Schiavinato A, Siliprandi R, and Vitadello M (1984) Ganglioside treatment of genetic and alloxan-induced diabetic neuropathy. Adv Exp Med Biol 174: 549–564PubMedGoogle Scholar
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    Dimpfel W, Möller W and Mengs U (1979) Ganglioside induced fiber outgrouth in cultured neuroblastoma cells. Naunyn Schmiedeberg’s Arch Pharmacol 308: K 46Google Scholar
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    Leon A, Facci L, Toffano G, Sonnino S and Tettamanti G (1981) Activation of (Na+, K+) ATPase by nanomolar concentrations of GM1 ganglioside. J Neurochem 37: 350–357PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • W. Dimpfel
    • 1
  • M. Spüler
    • 1
  • H.-U. Tüllner
    • 1
  1. 1.Pro Science Private Research Institute GmbHLinden 2Federal Republic of Germany

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