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Clinical Aspects on Bio-Medical Potential of Exogenous Gangliqside Application

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Gangliosides and Modulation of Neuronal Functions

Part of the book series: NATO ASI Series ((ASIH,volume 7))

Abstract

The therapy of neurological diseases of the centralor peripheral nervous system with an intramuscularly given ganglioside mixture is a symptomatic and non-causal treatment. Diseases of ganglioside deficiency are not known. The indication for therapy with gangliosides is based on the observation that gangliosides seem to stimulate nerve cell sprouting (1, 2). Even in biological systems a faster regeneration of neurites was observed after ganglioside mixtures were given intraperitoneally or locally. These results are reported elsewhere in this symposium. They leave many questions open, especially with respect to the efficiency and the site of action of this drug.

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References

  1. Norido F, Canella R, Anorti F (1981) Accleration of nerve regeneration by gangliosides estimated by the somatosensory evoked potentials (SEP) Experimentia 37: 301

    CAS  Google Scholar 

  2. Gorio A, Carmignoto G, Ferari A (1981) Axon sprouting stimulated by gangliosides: A new model for elongation and spronting. Rapport A Gerio, Gangliosides in Neurological and Neuromuscular Function, Revelopment and Repair. Raven Press, New York pp. 177–195

    Google Scholar 

  3. Bassi S, Albizzati M, Sbacchi M, Frattola L, Massarotti M (1984) Double-Blind Evaluation of Monosialogangliosid (GM 1) Therapy in Stroke, J of Neurosci Res 12: 493–498

    Article  CAS  Google Scholar 

  4. Tackmann W (1986) Elektromyographie und Nervenleitgeschwindigkeit bei diabetischen, alkoholischen und medikamentös induzierten Polyneuropathien In:Neundörfer B, Sailer D. Interdisziplinäre Bestandaufnahme der Polyneuropathien. Perimed Erlangen pp. 120–122

    Google Scholar 

  5. Greene DA, Brown MJ, Braunstein SN, Schwartz SS, Abury AK, Winegard AJ (1981) Comparison of clinical course and segmential electrophysiological tests in diabetics with symptomatic polyneuropathy and its implications for clinical triaets. Diabetes 30: 139

    Article  PubMed  CAS  Google Scholar 

  6. Buchthal F, Rosenfalck A, Behse F (1984) Sensory potentials of normal and diseased nerves. In:Dyck PJ, Thomas PK, Lambert EH, Bunge R (eds.) Peripheral Neuropathy, Saunders, Philadelphia pp. 981–1015

    Google Scholar 

  7. Tackmann WG, Spalke G, Orginszus (1976) Quantitative histometric studies and relation of number and diameter of myelinated fibres to electrophysiological parameters in normal and sensory nerves of man. J Neurol 212: 71–84

    CAS  Google Scholar 

  8. Tackmann W. Kaeser HE, Berger W, Rüeger AN (1980) Sensory and motor parameters in leg nerves of diabetics: Inter-correlations and relationships to clinical symptoms. Eur Neurol 20: 344–350

    Google Scholar 

  9. De Blas Orlando A, Martinez Cubells J, Hernando Arrivas C, Del Pozo Garcia JM (1983) Gangliosides in the Post-surgery Treatment of Disc Protrusion. Revista Clinica Espanda 168: 193–198

    Google Scholar 

  10. Bernardi A, Uliari U, De Stefani D, Poluzzi P, Bernardi G, Dainese R, Caniato G (1983) I gangliosidi: nuova pro-spettiva terapeutica della neuropatia uremica. Clin Ter 104: 211–218

    PubMed  CAS  Google Scholar 

  11. Mamoli B, Brunner G, Mader R, Schanda H (1980) Effects of cerebral gangliosides in the alcoholic polyneuropathies. Europ Neurol 19: 320–326

    Article  PubMed  CAS  Google Scholar 

  12. Hallet M, Harrington H. Tyler HR, Flood T, Slater N (1984) Trials of Gangliodide Therapy for Amyotrophic lateral sclerosis and Diabetic Neuropathy in: Leeden RM, Yu RK, Rapport M, Suzuki K, Ganglioside structure, function, and biomedical potential. Plenum Press New York, London pp 575–579

    Google Scholar 

  13. Horowitz SH (1984) Ganglioside (Cronassial) Therapy in Diabetic Neuropathy in: Leeden RW, Yu LRU, Rapport M, Suzuki K (eds), Gangliosides structure, function, and biomedial potential. Plenum Press New York, London pp 593–600

    Google Scholar 

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Authors and Affiliations

  1. Department of Neurology, University of Hamburg, Martinistr. 52, D-2000, Hamburg 20, Germany

    B. Weisner

Authors
  1. B. Weisner
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Editor information

Editors and Affiliations

  1. Zoological Institute, University of Stuttgart-Hohenheim, Garbenstr. 30, 7000, Stuttgart 70, Germany

    Hinrich Rahmann

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© 1987 Springer-Verlag Berlin Heidelberg

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Weisner, B. (1987). Clinical Aspects on Bio-Medical Potential of Exogenous Gangliqside Application. In: Rahmann, H. (eds) Gangliosides and Modulation of Neuronal Functions. NATO ASI Series, vol 7. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71932-5_55

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  • DOI: https://doi.org/10.1007/978-3-642-71932-5_55

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-71934-9

  • Online ISBN: 978-3-642-71932-5

  • eBook Packages: Springer Book Archive

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