Abstract
A unique feature of the antigenicity of glycolipids is that the specificity of antibodies produced against them is mostly determined by the carbohydrate moiety. In general, glycolipids are poorly antigenic and to improve the immune response the lipid is often coupled to some inert support such as serum albumin or is injected in the form of a liposome with phospholipid and cholesterol. None of these supports is completely inert and often the immune response is weak. In an attempt to improve antigenicity the ganglioside GM1 and sulphatide have been coupled to glass beads using a heterobifunctional crosslinking agent recently described (1).
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References
Lingwood CA (1984) Production of glycolipid affinity matrices by the use of heterobifunctional crosslinking agents. J. Lipid Res 25: 1010–1012.
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© 1987 Springer-Verlag Berlin Heidelberg
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Wynn, C.H., Brown, R.G., Evans, J.E. (1987). Antigenicity of Gangliosides. In: Rahmann, H. (eds) Gangliosides and Modulation of Neuronal Functions. NATO ASI Series, vol 7. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71932-5_42
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DOI: https://doi.org/10.1007/978-3-642-71932-5_42
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-71934-9
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