Gliomas, which account for almost half of all central nervous system tumors (1), often affect middle-aged individuals and cause severe social problems. In the US approx. 20,000 cases per year are reported. The corresponding figure for Sweden is 300, and in the Federal Republic of Germany the incidence is estimated to 1/10,000. The prognosis for the malignant forms is very bad, and despite surgical excision followed by irradiation and chemotherapy there has not been any significant increase of the surrival time, which is approx. one year. This might be attributed to a number of factors such as the invasive growth, without sharp delimitation from surrounding normal tissue, the great heterogeneity within the same tumor and the lack of knowledge about the biology of the tumors. Monoclonal antibodies to tumor-associated antigens could prove very helpful in increasing our knowledge of the biology of gliomas and in improving diagnosis and therapy. However, the usefulness of such an antibody depends on its specificity, and those produced so far have shown questionable specificity (2).
KeywordsHuman Glioma Human Glioma Cell Line Neuroectodermal Origin Embryonal Carcinoma Cell Line Ganglioside Content
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