Skip to main content
SpringerLink
Log in
SpringerLink
Log in

Gangliosides as Autoantigens and Differentiation Antigens

  • Conference paper
Gangliosides and Modulation of Neuronal Functions

Part of the book series: NATO ASI Series ((ASIH,volume 7))

Abstract

In this article I shall briefly review our studies on gangliosides, glycolipids and related glycoconjugates that are target antigens of monoclonal autoantibodies in sera of patients with autoimmune haemolytic disorders. These natural monoclonal autoantibodies are known as cold autoagglutinins because they cause intense agglutination of erythrocytes in the cold (ie below body temperature). They are of unusual interest, first, because their specificities involve carbohydrate differentiation antigens on erythrocytes and other cell types, and, second, they have provided clues to the pathogenesis of autoantibody production following infections.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Childs RA. Feizi T. Fukuda M, Hakomori S (1978) Blood group I activity associated with Band 3, the major intrinsic membrane protein of human erythrocytes. Biochem J 173: 333–336

    PubMed  CAS  Google Scholar 

  • Childs RA, Feizi T (1981) Differences in carbohydrate moieties of high molecular weight glycoproteins of human lymphocytes of T and B origins revealed by monoclonal autoantibodies with anti-l and anti-i specificities. Biochem Biophys Res Commun 102: 1158–1164

    Article  PubMed  CAS  Google Scholar 

  • Childs RA. Dalchau R. Scudder P. Hounsell EF, Fabre JW, Feizi T (1983) Evidence for the occurrence of O-glycosidically linked oligosaccharides of poly-N- acetyllactosamine type on the human leucocyte common antigen. Biochem: Biophys Res Commun 110: 424–431

    Article  CAS  Google Scholar 

  • Feizi T (1981a) The blood group li system: a carbohydrate antigen system defined by naturally monoclonal or oligoclonal autoantibodies of man. Immunol Commun 10: 127–156

    PubMed  CAS  Google Scholar 

  • Feizi T (1981b) Carbohydrate differentiation antigens. Trends Biochem Sci 6: 333–335

    Article  CAS  Google Scholar 

  • Feizi T (1985) Demonstration by monoclonal antibodies that carbohydrate structures of glycoproteins and glycolipids are onco-developmental antigens. Nature 314: 53–57

    Article  PubMed  CAS  Google Scholar 

  • Feizi T, Taylor-Robinson D, Shields MD, Carter RA (1969) Production of cold agglutinins in rabbits immunized with human erythrocytes treated with Mycoplasma pneumoniae. Nature 222: 1253–1256.

    Article  PubMed  CAS  Google Scholar 

  • Feizi T, Kabat EA, Vicari G, Anderson B., Marsh W (1971a) Immunochemical studies on blood groups. XLVII. The I antigen complex — Precursors in the A, B, H, Lea, and Leb blood group system-hemagglutination inhibition studies. J Exp Med 133: 39–52

    Article  PubMed  CAS  Google Scholar 

  • Feizi T, Kabat EA, Vicari G, Anderson B. March W (1971b) Immunochemical studies on blood groups XLIX. The I antigen complex; specificity differences among nti-l sera revealed by quantitative precipitin studies: partial structure of the I determinant specific for one anti-I serum. J Immunol 106: 1578–1592

    PubMed  CAS  Google Scholar 

  • Feizi T, Childs RA. Hakomori S. Powell ME (1978) Blood group l active gangliosides of human erythrocyte membranes. Biochem J 173: 245–254

    PubMed  CAS  Google Scholar 

  • Feizi T, Childs RA, Watanabe K, Hakomori S (1979) Three types of blood group I specificity among monoclonal anti-l autoantibodies revealed by analogues of a branched erythrocyte glycolipid. J Exp Med 149: 975–980

    Article  PubMed  CAS  Google Scholar 

  • Feizi T, Kapadia A, Gool HC, Evans M. (1982) Human monoclonal autoantibodies detect changes in expression and polarization of the li antigens during cell differentiation in early mouse embryos and teratocarcinomas. In: Teratocarcinoma and Embryonic cell interactions. Muramatsu T, Gachelin G, Moscona A, Ikawa Y (eds) Japan Scientific Societies Press & Academic Press, Tokyo pp. 201–215

    Google Scholar 

  • Feizi T and Hadier N. (1983) Autoantibodies and disease. In: Biochemical Aspects of Human Disease. Blackwell Scientific Publications pp. 656–692

    Google Scholar 

  • Feizi T, Gool HC, Loomes LM, Suzuki Y, Suzuki T, Matsumoto M (1984) Cryptic I antigen activity and Mycoplasma pneumoniae receptor activity associated with sialoglycoprotein GP-2 bovine eryithrocyte membranes. Biosci Rep 4: 743–749

    Article  PubMed  CAS  Google Scholar 

  • Feizi T, Childs RA (1985) Carbohydrate structures of glycoproteins and glycolipids as differentiation antigens, tumour-associated antigens and components of receptor systems. Trends Biochem Sci 10: 24–29

    Article  CAS  Google Scholar 

  • Hakomori S (1985) Aberrant glycosylation in cancer cell membranes as focused on glycolipids: overview and perspectives. Cancer Res 45: 2405–2414

    PubMed  CAS  Google Scholar 

  • Hansson GC, Karlsson K-A, Larson G, Stromberg N, Thurin J, Orvell C. Norrby E (1984) A novel approach to the study of glycolipid receptors for viruses. Binding of sendai virus to thin-layer chromatograms. FEBS Letts 170: 15–18.

    Article  CAS  Google Scholar 

  • Kabat EA (1982): Contributions of quantitative immunochemistry to knowledge of blood group A, B, H, Le, I and i antigens. Am J Clin Pathol 78: 281–292

    PubMed  CAS  Google Scholar 

  • Kabat EA, Liao J, Shyong J, Osserman EF (1982) A monoclonal IgM macroglobulin with specificity for lacto-N-tetraose in a patient with bronchogenic carcinoma. J Immunol 128: 540–544

    PubMed  CAS  Google Scholar 

  • Kannagi R, Roelcke D, Peterson KS, Okada Y, Levery SB, Hakomori S (1983) Characterization of an epitope (determinant) structure in a developmental regulated glycolipid antigen defined by a cold agglutinin Fl, recognition of α-sialsyl and α-L-fucosyl groups in a branched structure. Carbohyd Res 120: 143–157

    Article  CAS  Google Scholar 

  • Kapadia A, Feizi T, Evans MJ (1981a) Changes in the expression and polarization of blood group I and i antigens in post-implantation embryos and teratocarcinomas of mouse associated with cell differentiation. Exp Cell Res 131: 185–195

    Article  PubMed  CAS  Google Scholar 

  • Kapadia A, Feizi T, Jewell D, Keeling J, Slavin G (1981b) Immunocytochemical studies of blood group A, H, I and i antigens in gastric mucosae of infants with normal gastric histology and of patients with gastric carcinoma and chronic benign peptic ulceration. J Clin Path 34: 320–337

    Article  PubMed  CAS  Google Scholar 

  • Koscielak J, Miller-Podraza H, Krauze R, Piasek A (1976) Isolation and characterization of poly(glycosyl) ceramides (megaloglycolipids) with A, H and I blood-group activities. Europ J Biochem 71: 9–18

    Article  PubMed  CAS  Google Scholar 

  • Loomes LM, Uemura K-I, Childs RA, Paulson JC, Rogers GN, Scudder PR, Michalski J-C, Hounsell EF, Taylor-Robinson D, Feizi T (1984) Erythrocyte receptors for Mycoplasma pneumoniae are sialylated oligosaccharides of li antigen type. Nature 307: 560–563

    Article  PubMed  CAS  Google Scholar 

  • Loomes LM, Uemura K-I, Feizi T (1985) Interaction of Mycoplasma pneumoniae with erythrocyte glycolipids of I and i antigen types. Infect Immun 47: 15–20

    PubMed  CAS  Google Scholar 

  • Magnani JL, Smith, D. F. and Ginsburg, V. (1980) Detection of gangliosides that bind cholera toxin: direct binding of 125l-labeled toxin to thin-layer chromatograms. Analyt Biochem 109: 399–402.

    Article  PubMed  CAS  Google Scholar 

  • Niemann H, Watanabe K, Hakomori S, Childs RA & Feizi, T. (1978) Blood group i and I activities of “Lacto-N-norhexaosyl ceramide” and its analogues: the structural requirements for i-specificities. Biochem Biophys Res Commun, 81, 1286–1293.

    Article  PubMed  CAS  Google Scholar 

  • Picard J, Waldron Edward D & Feizi T. (1978) Changes in the expression of the blood group A, B, H, Lea and Leb antigens and the blood group precursor associated l(Ma) antigen in glycoprotein-rich extracts of gastric carcinomas. J Clin Lab Immunol 1: 119–128

    CAS  Google Scholar 

  • Picard JK, and Feizi T (1984) Carbohydrate antigens on glycoproteins of the neoplastic and uninvolved mucosae of patients with carcimoma of the stomach and colon. Biochem Soc Tansact 12, 651–653.

    Google Scholar 

  • Picard JK, Loveday D, Feizi T (1985) Evidence for sialylated Type 1 blood group chains on human erythrocyte membranes revealed by agglutination of neuraminidase-treated erythrocytes with Waldenstrom’s macroglobulin lgMWOO and hybridoma antibody FC 10.2. Vox Sang, 48: 26–33.

    Article  PubMed  CAS  Google Scholar 

  • Pruzanski W, and Shumak KH (1977). Biological activity of cold-reacting autoantibodies. N. Engl J Med 297: 583–589.

    Article  PubMed  CAS  Google Scholar 

  • Roelcke D, (1974) cold agglutination. Antibodies and antigens. Clin Immunol Immunopath 2: 266–280.

    Article  CAS  Google Scholar 

  • Roelcke D, (1981) A further cold aglutinin, F1, recognizing a N-Acetyineuraminic acid-determined antigen. Vox Sang 41: 98–101.

    Article  PubMed  CAS  Google Scholar 

  • Tang PW. Gool HC, Hardy M, Lee YC & Feizi T (1985) Novel approach to the study of the antigenicities and receptor functions of carbohydrate chains of glycoproteins. Biochem Biophys Res Commun 132: 474–480.

    Article  PubMed  CAS  Google Scholar 

  • Tang PW & Feizi T (1987) New glycolipid micro-immunoasays applied to the oligosaccharides of human milk galactosyltransferase detect blood group related antigens on both O- and N-linked chains. Carbohydr Res (in press).

    Google Scholar 

  • Thorpe SJ and Feizi T (1984) Species differences in the expression of carbohydrate differentiation antigens on mammalian blood cells revealed by immuno¬fluorescence with monoclonal antibodies. Biosci Reps 4: 673–685.

    Article  CAS  Google Scholar 

  • Uemura K, Childs RA, Hanfland P, and Feizi T (1983) A multiplicity of erythrocyte glycolipids of the neolacto series revealed by immuno-thin layer chromatography with monoclonal anti-l and anti-i antibodies. Biosci Reps 3: 577–588.

    Article  CAS  Google Scholar 

  • Uemura K, Roelcke D, Nagai Y, Feizi T (1984) The reactivities of human erythrocytes antoantibodies anti-Prg, anti-Gd, F1 and Sa with gangliosides in a chromatogram binding assay. Biochem J 219: 865–874.

    PubMed  CAS  Google Scholar 

  • Uemura K-I, Macher, BA, DeGregorio, M, Scudder P, Buehler J, Knapp W, Feizi T (1985). Glycosyphingolipid carriers of carbohydrate antigens of human myeloid cells recognized by monoclonal antibodies. Biochem Biophys Acta 846: 26–36.

    Article  PubMed  CAS  Google Scholar 

  • Watanabe K, Hakomori S, Childs RA. Feizi T (1979). Characterization of a blood group l-active ganglioside. Structural requirements for I and i specificities. J Biol Chem 254., 3221–3228.

    Google Scholar 

  • Walkins, MW (1980) Biochemistry and genetics of the ABO, Lewis and P blood group systems. In: Advances in Hman Genetics. Vol. 10 (Harris, H., Hirschhorn, K.) (eds) pp 1–136, 379–385. Plenum Press Co. New York.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Applied Immunochemistry Research Group, MRC Clinical Research Centre, Watford Road, Harrow, Middlesex, HA1 3UJ, UK

    T. Feizi

Authors
  1. T. Feizi
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Zoological Institute, University of Stuttgart-Hohenheim, Garbenstr. 30, 7000, Stuttgart 70, Germany

    Hinrich Rahmann

Rights and permissions

Reprints and permissions

Copyright information

© 1987 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Feizi, T. (1987). Gangliosides as Autoantigens and Differentiation Antigens. In: Rahmann, H. (eds) Gangliosides and Modulation of Neuronal Functions. NATO ASI Series, vol 7. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71932-5_36

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-71932-5_36

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-71934-9

  • Online ISBN: 978-3-642-71932-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation