Brain Gangliosides and Neurological Mutants

  • Nicole A. Baumann
  • M. L. Harpin
  • A. Baron-Van Evercooren
  • M. Iwamori
  • Yves Maurin
Part of the NATO ASI Series book series (volume 7)


Modifications of glycolipids occur during development. Some glycosphingolipids are known to be stage-specific antigens during embryogenesis.Numerous surface antigens developmentally regulated and detected by monoclonal antibodies are glycosphingolipids,some of which being minor components of a cell. Striking modifications of the ganglioside profile occur during development of the nervous system; some of them appear to be linked to cellular proliferation (1), others to neuronal differentiation (1,2), and to myelinogenesis(3,4). Thus it is likely that,in the nervous system,these glycolipids play a role in mechanisms of cell-cell recognition and communication, hormone-receptor or growth factor-receptor interactions.


Purkinje Cell Schwann Cell Myelin Basic Protein Neural Cell Adhesion Molecule Brain Ganglioside 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • Nicole A. Baumann
    • 1
  • M. L. Harpin
    • 1
  • A. Baron-Van Evercooren
    • 1
  • M. Iwamori
    • 2
  • Yves Maurin
    • 1
  1. 1.Laboratoire de Neurochimie, INSERM U 134Hôpital de la SalpêtrièreParis cedex 13France
  2. 2.Department of BiochemistryUniversity of TokyoShinju-kuJapan

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