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Involvement of Protein Synthesis in the Antiproliferative and the Antiviral Action of Prostaglandins

  • M. G. Santoro
Part of the Proceedings in Life Sciences book series (LIFE SCIENCES)

Abstract

For several years, we have studied the role of prostaglandins in the proliferation and differentiation of tumor cells.

Keywords

Virus Replication Antiviral Action K562 Cell Vesicular Stomatitis Virus Sendai Virus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

cAMP

cyclic adenosine 3′:5′-monophosphate

m.o.i.

multiplicity of infection

p.f.u.

plaque forming unit

p.i.

post infection

SDS

sodium dodecyl sulphate

PAGE

Polyacrylamide gel electrophoresis

Act. D

actinomycin D

HAU

hemagglutinating units

HAD

hemadsorption

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References

  1. Amici C, Benedetto A, Elia G, Garaci E, Santoro MG (1986a) Mechanism of the antiviral action of prostaglandin A in Sendai virus-infected cells. In: International Conference on Prostaglandins (Abstracts), 3-6 June 1986. Florence, Italy, p 202Google Scholar
  2. Amici C, Elia G, Benedetto A (1986b) Effect of prostaglandins on the growth, morphology and metabolic activity of an adhesive variant of FLC. In: 1986 International Conference on Prostaglandins and Cancer Abstracts, 8–10 June 1986. Rome, Italy, p 41Google Scholar
  3. Ankel H, Ahrens P (1986) Effect of prostaglandins on virus replication, cell growth and NK cell activity. In: International Conference on Prostaglandins (Abstracts), 3-6 June 1986. Florence, Italy, p 197Google Scholar
  4. Ankel H, Mittnacht S, Jacobsen H (1985) Antiviral activity of Prostaglandin A on encephalomyocarditis virus-infected cells: a unique effect unrelated to interferon. J Gen Virol 66: 2355–2364PubMedCrossRefGoogle Scholar
  5. Baker K, Thomas J, Epstein J, Possilico D, Stone M (1982) The effect of prostaglandins on the multiplication and cell-to-cell spread of herpes simplex virus type 2 in vitro. Am J Obstet Gynecol 144: 346–349PubMedGoogle Scholar
  6. Benavente J, Esteban M, Jaffe BM, Santoro MG (1984) Selective inhibition of viral gene expression as the mechanism of the antiviral action of PGA1 in vaccinia virus-infected cells. J Gen Virol 65: 599–608PubMedCrossRefGoogle Scholar
  7. Benedetto A, Zaniratti S, Meo P, Rossi GB (1979) Modulation by cell trypsinization of Sendai virus expression in African green monkey kidney cells: first infection and establishment of a carrier state. J Gen Virol 45: 407–421PubMedCrossRefGoogle Scholar
  8. Bhuyan BK, Adams EG, Badiner GJ, Li LH, Barden K (1986) Cell cycle effects of prostaglandins A1, A2 and D2 in human and murine melanoma cells in culture. Cancer Res 46: 1688–1693PubMedGoogle Scholar
  9. Burdon RH (1982) The human heat-shock proteins: their induction and possible intracellular functions. In: Schlesinger MJ, Ashburner M, Tissieres A (eds) Heat shock from bacteria to man. Cold Spring Harbor Laboratory, New York, pp 283–288Google Scholar
  10. Chatis PA, Morrison TG (1983) Characterization of the soluble glycoprotein released from vesicular stomatitis virus-infected cell. J Virol 45: 80–90PubMedGoogle Scholar
  11. Dore-Duffy P (1982) Differential effects of prostaglandins and other products of arachidonic acid metabolism on measles virus replication in Vero cells. Prostaglandin Leukotriene Med 8: 73–82CrossRefGoogle Scholar
  12. Giron DJ (1982) Inhibition of viral replication in cell cultures treated with Prostaglandin Et. Proc Soc Exp Biol Med 170: 25–28PubMedGoogle Scholar
  13. Hammarström S (1977) Prostaglandins production by normal and transformed 3T3 fibroblasts in cell culture. Eur J Biochem 74: 7–12PubMedCrossRefGoogle Scholar
  14. Harbour DA, Blyth WA, Hill TJ (1978) Prostaglandins enhance spread of herpes simplex virus in cell cultures. J Gen Virol 41: 87–95PubMedCrossRefGoogle Scholar
  15. Honma Y, Kasukabe T, Hozumi M, Koshihara Y (1980) Regulation of prostaglandin synthesis during differentiation of cultured mouse myeloid leukemia cells. J Cell Physiol 104: 349–357PubMedCrossRefGoogle Scholar
  16. Hughes-Fulford M, Wu J, Kato T, Fukushima M (1985) Inhibition of DNA synthesis and cell cycle by prostaglandins independent of cyclic AMP. In: Hayaishi O, Yamamoto S (eds) Advances in Prostaglandin, Thromboxane and Leukotriene Research, vol 15. Raven, New York, pp 401–404Google Scholar
  17. Jimenez de Asua L, Poskoeil S, Foecking MK, Otto AM (1984) N-glycosylation of nascent proteins in the prereplicative phase constitutes a process for controlling animal cell proliferation. In: Dumont JE, Ninez J (eds) Hormones and cell regulation, vol 8. Elsevier, Amsterdam, pp 37–51Google Scholar
  18. Karmali RA, Sarkar NH, Whittington E, Good RA (1982) Prostaglandin regulation of murine mammary tumor virus production: a basis for some of the glucocorticoid and prolactin actions on mammary tumor cell cultures. Prostaglandin Leukotriene Med 9: 641–655CrossRefGoogle Scholar
  19. Kawamura M, Koshihara Y (1984) Prostaglandin D2 lowers nuclear DNA polymerase activity in cultured mastocytoma cells. Prostaglandins 27: 517–525PubMedCrossRefGoogle Scholar
  20. Lewin B (1985) Genes I I. Wiley, New YorkGoogle Scholar
  21. Lozzio CB, Lozzio BB(1975) Human chronic myelogenous leukemia cell-line with positive Philadelphia chromosome. Blood 45: 321–334Google Scholar
  22. Luczak K, Gumulka S, Szmigielski S, Korbecki M (1975) Inhibition of multiplication of parainfluenza 3 virus in prostaglandin-treated WISH cells. Arch Virol 49: 377–380PubMedCrossRefGoogle Scholar
  23. Maheshwari RK, Banerjee DK, Waechter CJ, Olden K, Friedman RN (1980) Interferon treatment inhibits glycosylation of a viral protein. Nature 287: 454–456PubMedCrossRefGoogle Scholar
  24. Moore MAS (1982) G-CSF: its relationship to leukemia differentiation-inducing activity and other hemopoietic regulators. J Cell Physiol 1: 53–64CrossRefGoogle Scholar
  25. Narumiya S, Fukushima M (1985) Δ12-prostaglandin J2, an ultimate metabolite of prostaglandin D2 exerting cell growth inhibition. Biochem Biophys Res Commun 127: 739–745Google Scholar
  26. Olsson IL, Breitman TR, Gallo RC (1982) Priming of human myeloid leukemia cell lines HL-60 and U-937 with retinoic acid for differentiation effects of cyclic adenosine 3′:5′-monophosphate-inducing agents and a T-lymphocyte-derived differentiation factor. Cancer Res 42: 3928–3933PubMedGoogle Scholar
  27. Ono K, Nakane H, Kato T, Fukushima M (1986) Inhibitory effects of various prostaglandin derivatives on the activity levels of DNA polymerase in cultured cells. In: International Conference on Prostaglandins (Abstracts), 3-6 June 1986. Florence, Italy, p 413Google Scholar
  28. Ritzi EM, Stylos WA (1976) Prostaglandin production in cultures of BALB/3T3 and SV3T3 mouse fibroblasts. JNCI 56: 529–533PubMedGoogle Scholar
  29. Santoro MG, Jaffe BM (1987) Prostaglandins and differentiation of Friend erythroleukemia cells. In: Hammarström S (ed) Prostaglandins and tumor cell proliferation and differentiation. Martinus Nijhoff, The Hague (in press)Google Scholar
  30. Santoro MG, Philpott GW, Jaffe BM (1976) Inhibition of tumor growth in vivo and in vitro by prostaglandin E. Nature 263: 777–779CrossRefGoogle Scholar
  31. Santoro MG, Benedetto A, Jaffe BM (1979) Prostaglandin A1 induces differentiation in Friend erythroleukemia cells. Prostaglandins 17: 719–727PubMedCrossRefGoogle Scholar
  32. Santoro MG, Benedetto A, Carruba G, Garaci E, Jaffe BM (1980) Prostaglandin A compounds as antiviral agents. Science 209: 1032–1034PubMedCrossRefGoogle Scholar
  33. Santoro MG, Carruba G, Garaci E, Jaffe BM, Benedetto A (1981) Prostaglandins of the A series inhibit Sendai virus replication in cultured cells. J Gen Virol 53: 75–83PubMedCrossRefGoogle Scholar
  34. Santoro MG, Jaffe BM, Elia G, Benedetto A (1982a) Prostaglandin At induces the synthesis of a new protein in cultured AGMK cells. Biochem Biophys Res Commun 107: 1179–1184PubMedCrossRefGoogle Scholar
  35. Santoro MG, Jaffe BM, Garaci E, Esteban M (1982b) Antiviral effect of prostaglandin of the A series: inhibition of vaccinia virus replication in cultured cells. J Gen Virol 63: 435–440PubMedCrossRefGoogle Scholar
  36. Santoro MG, Jaffe BM, Esteban M (1983a) Prostaglandin A inhibits the replication of vesicular stomatitis virus: effect on virus glycoprotein. J Gen Virol 64: 2797–2801PubMedCrossRefGoogle Scholar
  37. Santoro MG, Benedetto A, Zaniratti S, Garaci E, Jaffe BM (1983b) The relationship between prostaglandins and virus replication. Prostaglandins 25: 353–364PubMedCrossRefGoogle Scholar
  38. Santoro MG, Crisari A, Benedetto A, Amici C (1986) Modulation of the growth of a human erythroleukemic cell line (K562) by prostaglandins: antiproliferative action of PGAs. Cancer Res 46: 6073–6077PubMedGoogle Scholar
  39. Santoro MG, Fukushima M, Benedetto A, Amici C (1987) PGJ2, a new antiviral prostaglandin: inhibition of Sendai virus replication and alteration of virus protein synthesis. J Gen Virol 68 (in press)Google Scholar
  40. Schmidt MF, Schlesinger MJ (1979) Fatty acid binding to vesicular stomatitis virus glycoprotein: a new type of post-translational modification of the viral glycoprotein. Cell 17: 813–819PubMedCrossRefGoogle Scholar
  41. Svec J, Svec P, Halcak L, Thurzo V (1982) Role of natural prostaglandins in the control of murine mammary tumor virus expression. J Cancer Res Clin Oncol 103: 55–67PubMedCrossRefGoogle Scholar
  42. Tabuse Y, Furusawa M, Eisen H, Shibata K (1977) Prostaglandin Ex, an inducer of erythroid differentiation of Friend erythroleukemia cells. Exp Cell Res 108: 41–45PubMedGoogle Scholar
  43. Trofatter K, Daniels C (1980) Effect of prostaglandins and cyclic adenosine 3′,5′-monophosphate modulators on herpes simplex virus growth and interferon response in human cells. Infect Immun 27: 158–164PubMedGoogle Scholar
  44. Yaron M, Yaron I, Caspi D, Smetana O, Eylan E, Zor U (1981) RNA and DNA viral stimulation of prostaglandin E production by human synovial fibroblasts. Arthritis Rheum 24: 1582–1586Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • M. G. Santoro
    • 1
  1. 1.Institute of Experimental MedicineCNR, II University of RomeRomeItaly

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