The Arachidonate Cascade and Mouse Skin Tumor Promotion

  • S. M. Fischer
Part of the Proceedings in Life Sciences book series (LIFE SCIENCES)

Abstract

The observations of Janoff et al. (1970) and Marks et al. (1982) that the application of the tumor promoter TPA induces cytotoxicity, inflammation, and vascular permeability changes provided the basis for inquiry into the involvement of arachidonate metabolites in such manifestations and in the tumor promotion process. Mouse skin is one of the more commonly used organs in experimental carcinogenesis studies and has proved to be one of the best model systems for studying the multistage nature of carcinogenesis (Berenblum and Shubik 1947; Slaga et al. 1980a, 1981a). Skin tumors in mice can be readily induced by the sequential application of a subthreshold dose of a carcinogen (initiation stage) followed by repetitive treatment with a noncarcinogenic tumor promoter (promotion stage). Promotion is most often accomplished by using 12-O-tetradecanoyl phorbol-13-acetate (TPA), although a variety of agents have been identified as skin tumor promoters, including benzoyl peroxide, anthralin, and dihydroteleocidin B (Slaga 1984). Promotion can be further subdivided such that the appropriate sequential use of incomplete or partial promoters such as the calcium ionophore A-23187 (first stage promoter) and mezerein (second stage) can supplant the use of a complete promoter.

Keywords

Lipase Superoxide Psoriasis Catalase PGE2 

Abbreviations

TPA

12-O-tetradecanoyl phorbol-13-acetate

ODC

ornithine decarboxylase

PGs

prostaglandins

NDGA

nordihydroguaiaretic acid

HETE

hydroxyeicosatetraenoic acid

HPETE

hydroperoxyeicosatetraenoic acid

SOD

superoxide dismutase

CuDIPS = Cu(II)(3,4

diisopropyl salicylic acid)2

CL

chemiluminescence.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • S. M. Fischer
    • 1
  1. 1.Science Park-Research DivisionUniversity of Texas System Cancer CenterSmithvilleUSA

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