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Role of Prostaglandins, Interleukin-1, Interferon-γ and Anti-Inflammatory Compounds in the Regulation of Thymocyte Proliferation

  • M. Papiernik
  • F. Homo-Delarche
Conference paper
Part of the Proceedings in Life Sciences book series (LIFE SCIENCES)

Abstract

T-cell precursors of bone marrow origin migrate to the thymus, where they differentiate and give rise to peripheral mature T-cells. The process of differentiation of T-cells is extremely complex, depending upon their microenvironment and the cells with which they are in contact. Cells which constitute the thymic stroma, mainly thymic epithelial cells of endo-ectodermic origin and thymic accessory cells of bone marrow origin, can modulate T-cell selection, proliferation and differentiation. Cell to cell recognition signals, mainly through class I and class II antigens encoded by the major histocompatibility complex (MHC) genes, as well as the secretion of factors are implicated in T-cell differentiation.

Keywords

PGE2 Production Accessory Cell Arachidonic Acid Metabolism Secondary Culture Bone Marrow Origin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Arenzana-Seisdedos F, Virelizier JL (1983) Interferon as macrophage activating factors. II. Enhanced secretion of interleukin 1 by lipopolysaccharide-stimulated human monocytes. Eur J Immunol 13: 437PubMedCrossRefGoogle Scholar
  2. Bach JF (1983) Thymulin (FTS-Zn). Clin Immunol Allergy 3: 133Google Scholar
  3. Bach JF, Dardenne M, Berrih S, Savino W, Papiernik M (1984) Regulation of the synthesis of humoral mediators of intra-thymic T-cell differentiation (thymic hormones, interleukin 1, interleukin 2). In: Cantor H, Chess L, Seracz L (eds) Regulation of the immune system. Alan R Liss, New York, p 329Google Scholar
  4. Boraschi D, Censini S, Tagliabue A (1984a) Interferon γ reduces macrophage-suppressive activity by inhibiting prostaglandin E2 release and inducing interleukin 1 production. J Immunol 133: 764PubMedGoogle Scholar
  5. Boraschi D, Censini S, Bartalini M, Scapigliati G, Barbaruli G, Vicenzi E, Donati MB, Tagliabue A (1984b) Interferon inhibit prostaglandin biosynthesis in macrophages: effects on arachidonic acid metabolism. J Immunol 132: 1987Google Scholar
  6. Boraschi D, Censini S, Bartalini M, Tagliabue A (1985) Regulation of arachidonic acid metabolism in macrophages by immune and non immune interferons. J Immunol 135: 502PubMedGoogle Scholar
  7. Dinarello CA, Marnoy SO, Rosenwasser LJ (1983) Role of arachidonate metabolism in the im- munoregulatory function of human leukocytic pyrogen/lymphocyte-activating factor/inter- leukin 1. J Immunol 130: 890PubMedGoogle Scholar
  8. Dore-Duffy P, Shih-Yieh H, Longo M (1985) The role of prostaglandins in altered leukocyte function in multiple sclerosis. Springer Semin, Immunopathol 8: 305CrossRefGoogle Scholar
  9. Durum S, Higushi C, Ron Y (1984) Accessory cells and T cell activation. The relationship between two components of accessory cell function: I-A and IL-1. Immunobiology 168: 213PubMedCrossRefGoogle Scholar
  10. Durum SK, Takacs L, Tartakovsky B (1985) IL1 production by murine macrophages andB cells. Regulation by T cells and la antigens. In: The physiologic, metabolic and immunologic actions of interleukin 1. Alan R Liss, New York, p 287Google Scholar
  11. El Rouby S, Praz F, Halbwachs-Mecarelli L, Papiernik M (1985) Thymic reticulum in mice. IV. The rosette formation between phagocytic cells of the thymic reticulum and cortical type thymocytes is mediated by complement receptor type III. J Immunol 134: 3625PubMedGoogle Scholar
  12. Homo F, Duval D, Papiernik M (1985) Prostaglandin production by phagocytic cells of the mouse thymic reticulum in culture and its modulation by indomethacin and corticosteroids. J Immunol 135: 506Google Scholar
  13. Homo-Delarehe F, De Saint-Basile G, Le Deist F, Smets P, Griscelli C (1986) Regulation of prostaglandin E2 and plasminogen activator by various immunomodulators in human monocytes. Prostaglandins Leukotrienes Med 21: 279CrossRefGoogle Scholar
  14. Johnson HM, Torres BA (1984) Leukotriene: positive signals for regulation of 7 interferon production. J Immunol 132: 413PubMedGoogle Scholar
  15. Kunkel SL, Chensue SW, Phan SH (1986) Prostaglandins as endogenous mediators of interleukin 1 production. J Immunol 136: 186PubMedGoogle Scholar
  16. Larson EL, Iscove MN, Coutinho A (1980) Two distinct factors are required for induction of T-cell growth. Nature 283: 664CrossRefGoogle Scholar
  17. Papiernik M,Homo-Delarche F (1983) Thymic reticulum in mice. III. Phagocytic cells of the thymic reticulum in culture secrete both PGE2 and IL1 which regulate thymocyte proliferation. Eur J Immunol 13: 689PubMedCrossRefGoogle Scholar
  18. Papiernik M, Nabarra B (1981) Thymic reticulum in mice. 1. Cellular ultrastrueture in vitro and functional role. Thymus 3: 345PubMedGoogle Scholar
  19. Papiernik M, Nabarra B, Savino W, Pontoux C, Barbey S (1983) Thymic reticulum in mice. II. Culture and characterization of non epithelial phagocytic cells of the thymic reticulum. Their role in the syngenic stimulation of thymic medullary lymphocytes. Eur J Immunol 13: 147PubMedCrossRefGoogle Scholar
  20. Papiernik M, Dombret H, Stefanos S, Wietzerbin J (1986) Control of la antigen expression on phagocytic cells of the thymic reticulum by interferon gamma and prostaglandins. Eur J Im-munol 16: 296CrossRefGoogle Scholar
  21. Penit C, Papiernik M (1986) Regulation of thymocyte proliferation and survival by deoxynucleoti- des. Deoxycytidine produced by thymic accessory cells protects thymocytes from deoxyguano- sine toxicity and stimulates their spontaneous proliferation. Eur J Immunol 16: 257PubMedCrossRefGoogle Scholar
  22. Reem GH, Cook LA, Vilcek J (1983) Gamma interferon synthesis by human thymocytes and T lymphocytes inhibited by cyclosporin A. Science 24: 63CrossRefGoogle Scholar
  23. Rola-Pleszczynski M, Lemaire I (1985) Leukotrienes augment interleukin 1 production by human monocytes. J Immunol 135: 3958PubMedGoogle Scholar
  24. Smith KA,Lachman LB, Oppenheim JJ, Favata MF (1980) The functional relationship of the interleukins. J Exp Med 151: 1551PubMedCrossRefGoogle Scholar
  25. Snyder DS, Beller DI, Unanue ER (1982) Prostaglandins modulate macrophage la expression. Nature 299: 163PubMedCrossRefGoogle Scholar
  26. Sonnenfeld G (1980) Modulation of immunity by interferon. In: Pick E (ed) Lymphokine report, vol. 1. Academic Press, London, pp 113Google Scholar
  27. Steeg PS, Moore RN, Oppenheim JJ (1980) Regulation of murine macrophage la-antigen expression by products of activated spleen cells. J Exp Med 152: 1734PubMedCrossRefGoogle Scholar
  28. Walker C, Kristensen F, Bettens F, de Week AL (1983) Lymphokine regulation of activated (Gx) lymphocytes. I. Prostaglandin E2-induced inhibition of interleukin 2 production. J Immunol 130: 1770PubMedGoogle Scholar
  29. Wong GH, Clark-Lewis I, Harris AW, Schrader JM (1984) Effect of cloned interferon-7 on expression of H-2 and la antigens on cell lines of hemopoietic, lymphoid, epithelial, fibroblastic and neuronal origin. Eur J Immunol 14: 52PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • M. Papiernik
  • F. Homo-Delarche
    • 1
  1. 1.INSERM U 25, CNRS UA 122Hôpital NeckerParisFrance

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