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Anti-Inflammatory Drugs and the Arachidonic Acid Cascade

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Prostaglandins in Cancer Research

Part of the book series: Proceedings in Life Sciences ((LIFE SCIENCES))

Abstract

As pharmacologists, we seek to find new drugs by many different interventions—anti-thrombotics or vasodilators for vascular disease, bronchodilators for asthma, antisecretory or cytoprotective drugs for ulcers, uterotropic substances and so on, but a single compound which has all of these activities (like some of the prostaglandins) does not make a useful drug—especially if it also causes diarrhoea. We have to have selectivity. The first real indication of selectivity in a prostaglandin with the possibility of therapeutic potential came with the discovery of prostacyclin (for review, see Vane 1982). The rest of the therapeutic promise arising from recent discoveries in the field of arachidonic acid metabolism is associated with enzyme inhibitors or eicosanoid antagonists.

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Authors and Affiliations

  1. The William Harvey Research Institute, St. Bartholomew’s Hospital Medical College, Charterhouse Square, London, EC1M 6BQ, England

    J. R. Vane

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  1. J. R. Vane
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Editors and Affiliations

  1. Department of Experimental Medicine, II University of Rome, Via O. Raimondo, 00173, Rome, Italy

    Enrico Garaci

  2. Institute of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133, Milan, Italy

    Rodolfo Paoletti

  3. Institute of Experimental Medicine, CNR, II University of Rome, Via O. Raimondo, 00173, Rome, Italy

    M. Gabriella Santoro

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© 1987 Springer-Verlag Berlin Heidelberg

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Vane, J.R. (1987). Anti-Inflammatory Drugs and the Arachidonic Acid Cascade. In: Garaci, E., Paoletti, R., Santoro, M.G. (eds) Prostaglandins in Cancer Research. Proceedings in Life Sciences. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71904-2_2

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  • DOI: https://doi.org/10.1007/978-3-642-71904-2_2

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