Skip to main content

Prostaglandins and Cancer: Clinical Approaches

  • Conference paper
  • 43 Accesses

Part of the book series: Proceedings in Life Sciences ((LIFE SCIENCES))

Abstract

Synthesis of prostaglandins (PCs) has been implicated in many aspects of cancer growth and development. In particular, experimental evidence indicates that PGs are involved in tumour osteolysis and development of bone metastases, in the interaction with the anti-tumour effects and toxicity of cytotoxic chemotherapy, and in cell replication, tumour development and growth.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Bennett A, Houghton J, Leaper DJ, Stamford IF (1979) Cancer growth, response to treatment and survival time in mice: beneficial effect of the prostaglandin synthesis inhibitor flurbiprofen. Prostaglandins 17: 179–191

    Article  PubMed  CAS  Google Scholar 

  • Eling TE, Honn KV, Busse WD, Senter F, Marnett LJ (1982) Stimulation of PGI2 biosynthesis by nafazatrom. In: Powles T J, Bockman RS, Honn KV, Ramwell P (eds) Prostaglandins and Cancer. Alan R Liss, New York, pp 783–787

    Google Scholar 

  • Favalli C, Gaxaci E, Santoro MG, Santucci L, Jaffe BM (1980) The effect of PGA1 on the immuno-response in melanoma bearing mice. Prostaglandins 19: 897–904

    Article  Google Scholar 

  • Galasko CSB, Bennett A (1976) Relationships of bone destruction in skeletal metastases to osteoclast activation and prostaglandins. Nature 263: 508–510

    Article  PubMed  CAS  Google Scholar 

  • Honn KV (1982) Prostacyclin/thromboxane ratios in tumor growth and metastasis. In: Powles TJ, Bockman RS, Honn KV, Ramwell P (eds) Prostaglandins and Cancer. Alan R Liss, New York, pp 733–752

    Google Scholar 

  • Honn KV, Davidowicz K, Bienowski M, Morgan LR, Marnett LJ (1979) Effects of prostaglandin A1 on Harding-passey melanoma macromolecular synthesis. Abstracts of 4th International Prostaglandin Conference, 27–31 May 1979. Washington DC, p 50

    Google Scholar 

  • Honn KV, Romine M, Skoff A (1981) Prostaglandins analogs as inhibitors of tumor cell DNA synthesis. Proc Soc Expt Biol Med 166: 562–567

    CAS  Google Scholar 

  • Powles TJ (1983) Administration of PGA, PGE and anti-inflammatory drugs to patients with cancer. Adv Prostaglandin Thromboxane Leukotriene Res 12: 327–331

    CAS  Google Scholar 

  • Powles TJ, Clark SA, Easty DM, Easty GC, Neville AM (1973) The inhibition by aspirin and indo-methacin of osteolytic tumour deposits and hypercalcaemia in rats with Walker tumour, and its possible application to human breast cancer. Br J Cancer 28: 316–321

    Article  PubMed  CAS  Google Scholar 

  • Powles TJ, Alexander P, Millar JL (1978) Enhancement of anticancer activity of cytotoxic chemotherapy with production of normal tissues by inhibition of prostaglandin synthesis. Biochem Pharmacol 27: 1389–1392

    Article  PubMed  CAS  Google Scholar 

  • Powles TJ, Muindi J, Coombes RC (1982) Mechanisms for development of bone metastases and effects of anti-inflammatory drugs. In: Powles TJ, Bockman R, Honn KV, Ramwell PW (eds) Prostaglandins and Cancer. Alan R Liss, New York, pp 541–553

    Google Scholar 

  • Santoro MG, Philpott GW, Jaffe BM (1976) Inhibition of tumour growth in vivo and in vitro by prostaglandin E. Nature 263: 777–779

    Article  CAS  Google Scholar 

  • Santoro MG, Benedetto A, Jaffe BM (1979) Prostaglandin A1 induces differentiation in Friend erythroleukemia cells. Prostaglandins 17: 719–727

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1987 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Powles, T.J. (1987). Prostaglandins and Cancer: Clinical Approaches. In: Garaci, E., Paoletti, R., Santoro, M.G. (eds) Prostaglandins in Cancer Research. Proceedings in Life Sciences. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71904-2_16

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-71904-2_16

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-71906-6

  • Online ISBN: 978-3-642-71904-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics