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Gastrointestinaler Proteinverlust

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Part of the book series: Interdisziplinäre Gastroenterologie ((GASTROENTEROLOG))

Zusammenfassung

Bei intestinalen Erkrankungen können vermehrt Plasmaproteine über den Magen-Darm-Trakt ausgeschieden werden. Wird ein exzessiver Proteinverlust nicht durch einen verminderten endogenen Katabolismus und eine gesteigerte Syntheserate kompensiert, kommt es zur Hypoproteinämie, die häufig mit Ödemen einhergeht.

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Literatur

  1. Baynes JW, Thorpe SR (1981) Identification of the sites of albumin catabolism in the rat. Arch Biochem Biophys 206:372–379

    Article  PubMed  CAS  Google Scholar 

  2. Crossley JR, Elliott RB (1977) Simple method for diagnosing protein-losing enteropathies. Br Med J 11: 428–429

    Article  Google Scholar 

  3. Dive Ch, Heremans JF (1974) Nature and origin of the proteins of bile I. A comparative analysis of serum and bile proteins in man. Eur J Clin Invest 4: 235–239

    Google Scholar 

  4. Florent C, L’Hirondel C, Desmazures C, Aymes C, Bernier JJ (1981) Intestinal clearance of a!-antitrypsin. A sensitive method for the detection of protein-losing enteropathy. Gastroenterology 81: 777–780

    Google Scholar 

  5. Granger DN, Cook BH, Taylor AE (1976) Structural locus of transmucosal albumin efflux in canine ileum. A fluorescent study. Gastroenterology 71: 1023–1027

    Google Scholar 

  6. Hardwicke J, Rankin JG, Baker KJ, Preisig R (1964) The loss of protein in human and canine hepatic bile. Clin Sc 26: 509–517

    CAS  Google Scholar 

  7. Iida F, Wada R, Sato A, Yamada T (1980) Clinicopathologic consideration of proteinlosing enteropathy due to lymphangiectasia of the intestine. Surg Gynecol Obstet 151: 391–395

    PubMed  CAS  Google Scholar 

  8. Jarnum S, Jensen KB (1972) Plasma protein turnover (albumin, transferrin, IgG, IgM) in Ménétrier’s disease (giant hypertrophic gastritis ): Evidence of non-selective protein loss. Gut 13: 128–137

    Google Scholar 

  9. Jones EA, Young WB, Morson BC, Dawson AM (1972) A study of six patients with hypertrophy of the gastric mucosa with particular reference to albumin metabolism. Gut 13: 270–277

    Article  PubMed  CAS  Google Scholar 

  10. Karbach U, Ewe K, Bodenstein H (1983) Alphar-antitrypsin, a reliable endogenous marker for intestinal protein loss and its application in patients with Crohn’s disease. Gut 24: 718–723

    Article  PubMed  CAS  Google Scholar 

  11. Kelly DG, Miller LJ, Malagelada JR, Huizenga KA, Markowitz H (1982) Giant hypertrophic gastropathy (Ménétrier’s disease): pharmacologic effects on protein leakage and mucosal ultrastructure. Gastroenterology 83: 581–589

    PubMed  CAS  Google Scholar 

  12. Kondo M, Bamba T, Hosokawa K, Hosoda S, Kawai K, Masuda M (1976) Tissue plasminogen activator in the pathogenesis of protein-losing gastroenteropathy. Gastroenterology 70: 1045–1047

    PubMed  CAS  Google Scholar 

  13. Krag E, Frederiksen H-J, Olson N, Henriksen JH (1978). Cimetidine treatment of protein- losing gastropathy Ménétrier’s Disease). A clinical and pathophysiological study. Scand J Gastroentol 13: 635–639

    Google Scholar 

  14. Krejs GJ, Horica C, Benes I, Blum AL (1975) Modifizierter r-Chrom-Albumin-Test zur Unterscheidung von exsudativer Gastro- und Enteropathie. Schweiz Med Wochenschr 105: 1135–1137

    PubMed  CAS  Google Scholar 

  15. Lev R, Brus I (1971). Morphologic and histochemical demonstration of protein in gastric surface epithelium in protein-losing gastropathies. Dig Dis 16: 589–598

    Article  CAS  Google Scholar 

  16. Miura S, Asakura H, Tsuchiya M (1981) Lymphatic abnormalities in protein-losing gastropathy, especially in Ménétrier’s disease. Angiology 32: 345–354

    Article  PubMed  CAS  Google Scholar 

  17. Munro DR (1974) Route of protein loss during a model protein-losing gastropathy in dogs. Gastroenterology 66: 960–972

    PubMed  CAS  Google Scholar 

  18. Reinhart WH, Weigand K, Rappeler M, Roesler H, Halter F (1983) Comparison of gastrointestinal loss of alpha-1-antitrypsin and chromium-51 -albumin in Ménétrier’s disease and the influence of ranitidine. Digestion 26: 192–196

    Article  PubMed  CAS  Google Scholar 

  19. Renston RH, Maloney DG, Jones AL, Hradek GT, Wong KY, Goldfine JD (1980) Bile secretory apparatus: evidence for a vesicular transport mechanism for proteins in the rat, using horseradish peroxidase and (125I)Insulin. Gastroenterology 78: 1373–1388

    PubMed  CAS  Google Scholar 

  20. Rogos R (1978) Untersuchungen zur Albuminexkretion der Leber in die Galle. I. Postoperative Albuminexkretion in die T-Drainage Galle Dtsch Z Verdau Stoffwechselkr 38: 21–26

    CAS  Google Scholar 

  21. Schiraldi O, Pastore C, Strada C, Marano R (1968) A histoautoradiographic study of protein loss in the intestine of antifolic treated rats. Experientia 24: 45–46

    Article  PubMed  CAS  Google Scholar 

  22. Schultze HE, Heremans JF (1966) In: Molecular biology of plasma proteins, vol I. Nature and metabolism of extracellular protein. Elsevier, Amsterdam

    Google Scholar 

  23. Tavill AS (1971) Protein-losing enteropathy. J Clin Path 24:Suppl. 5: 45–54

    Google Scholar 

  24. Waldmann TA (1966) Protein-losing enteropathy. Gastroenterology 50: 422–443

    PubMed  CAS  Google Scholar 

  25. Waldmann TA, Wochner RD, Strober W (1969) The role of the gastrointestinal tract in plasma protein metabolism. Am J Med 46: 275–285

    Article  PubMed  CAS  Google Scholar 

  26. Waldmann TA, Broder S, Strober W (1974) Protein-losing enteropathies in malignancy. Ann Amer NY Acad Sei 230: 306–317

    Article  CAS  Google Scholar 

  27. Weigand K (1977) Die Regulation des Serumalbuminspiegels unter physiologischen und pathologischen Bedingungen. Klin Wochenschr 55: 295–305

    Article  PubMed  CAS  Google Scholar 

  28. Weigand K (1980) Synthese, Verteilung und Bedeutung von Serumalbumin. In: Ahnefeld FW et al. (Hrsg) Therapie mit Blutkomponenten. Klinische Anästhesiologie und Intensivtherapie, Bd 21, S 52–64

    Google Scholar 

  29. Wochner RD, Weissman SM, Waldmann TA, Houston D, Berlin NI (1968) Direct measurement of the rates of synthesis of plasma proteins in control subjects and patients with gastrointestinal protein loss. J Clin Invest 47: 971–982

    Article  PubMed  CAS  Google Scholar 

  30. Yedgar S, Carew TE, Pittman RC, Beltz WF, Steinberg D (1983) Tissue sites of catabolism of albumin in rabbits. Am J Physiol 244:E101–E107

    PubMed  CAS  Google Scholar 

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© 1987 Springer-Verlag Berlin Heidelberg

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Weigand, K. (1987). Gastrointestinaler Proteinverlust. In: Koelz, H.R., Aeberhard, P. (eds) Gastroenterologische Pathophysiologie. Interdisziplinäre Gastroenterologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71876-2_16

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  • DOI: https://doi.org/10.1007/978-3-642-71876-2_16

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-71877-9

  • Online ISBN: 978-3-642-71876-2

  • eBook Packages: Springer Book Archive

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