Interaction of Mixed Agonist-Antagonists with Different Receptor Sites Using Nalbuphine as a Model Substance
Taking the prototype opiate receptors and their respective ligands, the mu-receptor is generally bound by morphine and the kappa-receptor by ethylketocyclazocine. A prototype for the delta-receptor, the binding site for most endogenous opioids, is leucine enkephalin (leu-enkephalin), a pentapeptide. It has a regulatory role in the nervous system for mediating analgesia, behavioural and endocrine changes. The sigma-receptor ligand is SKF10 047 (N-allylnormetazocine) which causes dysphoria and psychosis (Fig. 56).
KeywordsRespiration Fentanyl Heroin Tramadol Nitroglycerine
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