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Interaction of Mixed Agonist-Antagonists with Different Receptor Sites Using Nalbuphine as a Model Substance

  • Enno Freye

Abstract

Taking the prototype opiate receptors and their respective ligands, the mu-receptor is generally bound by morphine and the kappa-receptor by ethylketocyclazocine. A prototype for the delta-receptor, the binding site for most endogenous opioids, is leucine enkephalin (leu-enkephalin), a pentapeptide. It has a regulatory role in the nervous system for mediating analgesia, behavioural and endocrine changes. The sigma-receptor ligand is SKF10 047 (N-allylnormetazocine) which causes dysphoria and psychosis (Fig. 56).

Keywords

Respiratory Depression Receptor Site Myocardial Infarc Opioid Agonist Myocardial Oxygen Demand 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • Enno Freye
    • 1
    • 2
  1. 1.University of DüsseldorfDüsseldorf 1Germany
  2. 2.Department of Central DiagnosticsUniversity Clinic of EssenEssen 1Germany

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