Abstract
The chicken bursa of Fabrieius is a primary organ of differentiation for the B-cell lineage (Glick et al. 1956). Its removal during embryonic development (up to 17 days of incubation) induces severe agammaglobulinemia and prevents the animal from mounting an immune response to any immunizing antigen (Mueller et al. 1959; Cooper et al. 1969; Warner et al. 1969). The stem cells which give rise to B lymphocytes colonize the bursa from the general circulation (Moore and Owen 1965, 1966; Le Douarin etal. 1975). They migrate at a specific stage of embryonic development to the bursal mesenchyme, where some may develop into granulocytes. When they reach the bursal epithelium, they induce the formation of bursal follicles and differentiate into B lymphocytes (Houssaint et al. 1976).
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© 1987 Springer-Verlag Berlin Heidelberg
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Weill, JC., Leibowitch, M., Reynaud, CA. (1987). Questioning the Role of the Embryonic Bursa in the Molecular Differentiation of B Lymphocytes. In: Paige, C.J., Gisler, R.H. (eds) Differentiation of B Lymphocytes. Current Topics in Microbiology and Immunology, vol 135. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71851-9_8
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DOI: https://doi.org/10.1007/978-3-642-71851-9_8
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