Cloning of Murine B-Lymphocyte Differentiation Stage-Specific Genes

  • N. Sakaguchi
  • C. N. Berger
  • F. Melchers
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 135)


During differentiation of eukaryotic cells with specialized functions selected genes must be expressed which encode structures for these functions. We expect that the expression of these selected genes will occur in the differentiated cell type only, and in no other cell of the body, if the corresponding structures and functions are unique for the type of differentiated cell. Examples of selected gene expression are known in blood cells. Globin is expressed in red blood cells, the T-cell receptor for antigen in T cells, and immunoglobulin (Ig) in B cells only.


mRNA Preparation Immunoglobulin Heavy Chain Variable Region Basel Institute Murine Plasma Cell 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • N. Sakaguchi
    • 1
  • C. N. Berger
    • 1
  • F. Melchers
    • 1
  1. 1.Basel Institute for ImmunologyBaselSwitzerland

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