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Chemical Carcinogens in Tobacco

  • Conference paper
Cancer Risks

Abstract

The association of tobacco usage and cancer has been known for more than five decades. Clinical observations by F.H.Mueller in Cologne in 1939 and by Schairer and Schoeniger in Jena in 1943 were among the first reports to indicate an increased risk for lung cancer among smokers. However, it was not until 1950 that the evidence from case-control studies in the UK and the USA directed attention towards the association of cigarette smoking with lung cancer (Doll and Hill 1950; Levin et al. 1950; Wynder and Graham 1950). In the following 35 years, more than 100 epidemiological reports from at least 15 countries have formed the basis for the conclusions of the US Surgeon General (1982), the Royal College of Physicians (1983), and the International Agency for Research on Cancer (IARC 1986) that cigarette smoking is causally associated with cancer of the lung, larynx, oral cavity, and esophagus, and correlated with cancer of the pancreas, kidney, and urinary bladder, and, possibly also with cancer of the cervix. Cigar and pipe smoking are also causally associated with cancer of the lung, larynx, oral cavity, and esophagus, although the association of these tobacco habits with cancer of the lung and of the larynx is less strong than that of cigarette smoking. Passive smoking gives rise to some risk of cancer (IARC 1986). It has also been concluded that oral use of snuff is carcinogenic to humans (IARC 1985;US Surgeon General 1986).

Our tobacco research program is supported by U.S. National Cancer Institute grant P01-CA-29580

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References

  • Belinsky SA, White CM, Boucheron JA, Richardson FC, Swenberg JA, Anderson M (1986) Accumulation and persistence of DNA adducts in respiratory tissue of rats following multiple administration of the tobacco-specific carcinogen 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone. Cancer Res 46:1280–1284

    PubMed  CAS  Google Scholar 

  • Bernfeld P, Homburger F, Russfield AB (1974) Strain differences in the response of inbred Syrian hamsters to cigarette smoke inhalation. JNCI 53:1141–1157

    PubMed  CAS  Google Scholar 

  • Bock FG, Swain AP, Stedman RL (1971) Composition studies on tobacco LXIV. Tumor-promoting activity of subfractions of the weak acid fraction of cigarette smoke condensate. JNCI 47:429–436

    PubMed  CAS  Google Scholar 

  • Brunnemann KD, Scott JC, Hoffmann D (1982) N-nitrosomorpholine and other volatile N-nitrosamines in snuff tobacco. Carcinogenesis 3:693–696

    Article  PubMed  CAS  Google Scholar 

  • Brunnemann KD, Genoble L, Hoffmann D (1987) Identification and analysis of a new tobaccospecific N-nitrosamine, 4-(methylnitrosamino)-4-(3-pyridyl)-1-butanol. Carcinogenesis 8 (in press)

    Google Scholar 

  • Butts WC, Kuehneman M, Widdowson GM (1974) Automated method for determining serum thiocyanate to distinguish smokers from nonsmokers. Clin Chem 20:1344–1348

    PubMed  CAS  Google Scholar 

  • Castonguay A, Stoner GD, Schut HAJ, Hecht SS (1983) Metabolism of tobacco-specific N-nitrosamines by cultured human tissues. Proc Natl Acad Sci USA 80:6694–6697

    Article  PubMed  CAS  Google Scholar 

  • Castonguay A, Tharp R, Hecht SS (1984) Kinetics of DNA methylation of the tobacco specific carcinogen 5-(methyl-nitrosamino)-1-(3-pyridyl)-1-butanone in F344 rats. IARC Sci Publ 57:805–810

    PubMed  CAS  Google Scholar 

  • Dalbey WE, Nettesheim P, Griesemer R, Caton JE, Guerin MR (1980) Chronic inhalation of cigarette smoke by F344 rats. JNCI 64:383–388

    PubMed  CAS  Google Scholar 

  • Doll R (1971) Cancers related to smoking. Proceedings of the 2nd world conference on smoking and health. Pitman Medical, London, pp 10–23

    Google Scholar 

  • Doll R, Hill AB (1950) Smoking and carcinoma of the lung. Preliminary report. Br Med J 2:739–748

    Article  PubMed  CAS  Google Scholar 

  • Dontenwill WP (1974) Tumorigenic effect of chronic cigarette smoke inhalation on Syrian golden hamsters. In: Karbe E, Park JF (eds) Experimental lung cancer. Carcinogenesis and bioassays. Springer, Berlin Heidelberg New York, pp 331–359

    Google Scholar 

  • Dontenwill W, Chevalier HJ, Harke HP, Lafrenz U, Reckzeh G, Schneider B (1973) Investigations on the effects of chronic cigarette smoke inhalation in Syrian golden hamsters. JNCI 51:1781–1832

    PubMed  CAS  Google Scholar 

  • Dontenwill W, Chevalier HJ, Harke HP, Klimisch HJ, Reckzeh G, Fleischmann B, Keller W (1977) Experimentelle Untersuchungen über die tumorerzeugende Wirkung von Zigarettenrauch-Kondensaten an der Mäusehaut, VII. Mitteilung. Einzelbefunde von Kondensaten verschiedener modifizierter Zigaretten. Z Krebsforsch 89:145–151

    Article  CAS  Google Scholar 

  • Eudy LW, Thorne FA, Heavor DL, Green CR, Ingebrethsen BJ (1985) Studies on vapor-particulate phase distribution of environmental nicotine by selected trapping and detection methods. 39th Tobacco Chemists Research Conference, Montreal, Canada, abstract, p 25

    Google Scholar 

  • Haley NJ, Sepkovic DW, Hoffmann D, Wynder EL (1985) Cigarette smoking as a risk for cardiovascular disease, part VI. Compensation with nicotine availability as a single variable. Clin Pharmacol Ther 38:164–170

    Article  PubMed  CAS  Google Scholar 

  • Hecht SS, Thorne RL, Maronpot RR, Hoffmann D (1975) A study of tobacco carcinogenesis XIII. Tumor-promoting subfractions of the weakly acidic fraction. JNCI 55:1329–1336

    PubMed  CAS  Google Scholar 

  • Hecht SS, Carmella S, Mori H, Hoffmann D (1981) A study of tobacco carcinogenesis XX. Role of catechol as major cocarcinogen in the weakly acidic fraction of smoke condensate. JNCI 66:163–169

    PubMed  CAS  Google Scholar 

  • Hecht SS, Castonguay A, Rivenson A, Mu B, Hoffmann D (1983) Tobacco specific nitrosamines: carcinogenicity, metabolism and possible role in human cancer. J Environ Sci Health [C] 1:1–54

    Google Scholar 

  • Hecht SS, Trushin N, Castonguay A, Rivenson A (1986) A study of chemical carcinogenesis 88. Comparative carcinogenicity and DNA methylation in F344 rats by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and N-nitrosodimethylamine. Cancer 46:498–502

    CAS  Google Scholar 

  • Herning RI, Jones RT, Bachman J, Mines AH (1981) Puff volume increases when low-nicotine cigarettes are smoked. Br Med J 283:187–189

    Article  CAS  Google Scholar 

  • Hoffmann D, Brunnemann KD (1983) Endogenous formation of N-nitrosoproline in cigarette smokers. Cancer Res 43:5570–5574

    PubMed  CAS  Google Scholar 

  • Hoffmann D, Hecht SS (1985) Perspectives in cancer research. Nicotine-derived N-nitrosamines and tobacco-related cancer: current status and future directions. Cancer Res 45:935–944

    PubMed  CAS  Google Scholar 

  • Hoffmann D, Wynder EL (1971) A study of tobacco carcinogenesis XI. Tumor initiators, tumor accelerators, and tumor promoting activity of condensate fractions. Cancer 27:848–864

    Article  PubMed  CAS  Google Scholar 

  • Hoffmann D, Wynder EL (1972) Selective reduction of tumorigenicity of tobacco smoke II. Experimental approaches. JNCI 48:1855–1868

    PubMed  CAS  Google Scholar 

  • Hoffmann D, Wynder EL (1986) A study of tobacco carcinogenesis XXX. Chemical constituents and bioactivity of tobacco smoke. In: Zaridze DG, Peto R (eds) A Major International Health Hazard. IARC Sci Publ 74 (in press)

    Google Scholar 

  • Hoffmann D, Tso TC, Gori GB (1980) The less harmful cigarette. Prev Med 9:287–296

    Article  PubMed  CAS  Google Scholar 

  • Hoffmann D, Haley NJ, Adams JD, Brunnemann KD (1984) Tobacco sidestream smoke: uptake by nonsmokers. Prev Med 13:608–617

    Article  PubMed  CAS  Google Scholar 

  • Hoffmann D, Harley NH, Fisenne I, Adams JD, Brunnemann KD (1986) Carcinogenic agents in snuff. JNCI 76:435–437

    PubMed  CAS  Google Scholar 

  • Holly EA, Petrakis NL, Friend NF, Sarles DL, Lee RE, Flander LD (1986) Mutagenic mucus in the cervix of smokers. JNCI 76:983–986

    PubMed  CAS  Google Scholar 

  • IARC: International Agency for Research on Cancer (1985) Tobacco habits other than smoking; betel-quid and areca-nut chewing; and some related nitrosamines. IARC, Lyon, France (Monograph No 37)

    Google Scholar 

  • IARC: International Agency for Research on Cancer (1986) Tobacco smoking. IARC, Lyon, France (Monograph No 38)

    Google Scholar 

  • Jarvis MJ, Tunstall-Pedoe H, Feyerabend C, Vesley C, Salvojee Y (1984) Biochemical markers of smoke absorption and self-reported exposure to passive smoking. J Epidemiol Commun Health 38:335–339

    Article  CAS  Google Scholar 

  • Ladd KF, Newmark HL, Archer MC (1984) N-Nitrosation of proline in smokers and nonsmokers. JNCI 73:83–87

    PubMed  CAS  Google Scholar 

  • La Voie EL, Shigematsu A, Tucciarone PL, Adams JD, Hoffmann D (1985) Comparison of the steam-volatile components in commercial cigarette, pipe, and chewing tobaccos. J Agilc Food Chem 33:547–552

    Google Scholar 

  • Leuchtenberger C, Leuchtenberger R (1970) Effects of chronic inhalation of whole fresh cigarette smoke and of its gas phase on pulmonary tumorigenesis in Snell’s mice. In: Nettesheim P, Hanna MG Jr, Daatherage JW Jr (eds) Morphology of experimental respiratory carcinogenesis. US AEC, Oak Ridge, TN, pp 329–346

    Google Scholar 

  • Levin ML, Goldstein H, Gerhardt PR (1950) Cancer and tobacco smoking. A preliminary report. JAMA 143:336–338

    CAS  Google Scholar 

  • Lu SH, Ohshima H, Fu HM, Tian Y, Li FM, Blettner M, Wahrendorf J, Bartsch H (1986) Urinary excretion of N-nitrosamino acids and nitrate by inhabitants of high- and low-risk areas for esophageal cancer in Northern China: endogenous formation of nitrosoproline and its inhibition by vitamin C. Cancer Res 46:1485–1491

    PubMed  CAS  Google Scholar 

  • Mohr U, Reznik G (1978) Tobacco carcinogenesis. In: Harris CC (ed) Pathogenesis and therapy of lung cancer. Dekker, New York, pp 263–367

    Google Scholar 

  • Mueller FH (1939) Tabakmissbrauch und Lungencarcinom. Z Krebsforsch 49:57–84

    Google Scholar 

  • National Research Council (1981) The health effects of nitrate, nitrite and N-nitroso compounds. National Academy Press, Washington, DC, p 51

    Google Scholar 

  • Royal College of Physicians (1983) Health or smoking? Follow-up report of the Royal College of Physicians. Pitman, London

    Google Scholar 

  • Sasson IM, Haley NJ, Hoffmann D, Wynder EL, Hellberg D, Nilsson S (1985) Cervical neoplasia and cigarette smoking: quantitation of smoke constituents in cervical mucus. New Engl J Med 312:315–316

    PubMed  CAS  Google Scholar 

  • Schairer E, Schoeninger E (1943) Lungenkrebs and Tabakverbrauch. Z Krebsforsch 54:261–269

    Google Scholar 

  • Sepkovic DW, Haley NJ (1986) Metabolism of nicotine in smokers and nonsmokers. In: William RM et al (eds) Physiology and pharmacology of nicotine. Plenum, New York (in press)

    Google Scholar 

  • Tsuda M, Nutsuma J, Sato S, Hirayama T, Kakizoe T, Sugimura T (1986) Increase in the levels of N-nitrosoproline, N-nitrosothioproline, and N-nitroso-2-methylthioproline in human urine by cigarette smoking. Cancer Lett 30:117–124

    Article  PubMed  CAS  Google Scholar 

  • US Surgeon General (1982) The health consequences of smoking: cancer US Public Health Service, DHHS publication No (PHS) 82-50179

    Google Scholar 

  • US Surgeon General (1983) The health consequences of smoking: cardiovascular disease. US Public Health Service, DHHS publication No (PHS) 84-50204

    Google Scholar 

  • US Surgeon General (1986) Report of the surgeon general’s advisory committee on the health consequences of using smokeless tobacco. Washington, DC, NIH Publ No 862874

    Google Scholar 

  • Van Duuren BL, Goldschmidt BM (1976) Cocarcinogenic and tumor promoting agents in tobacco carcinogenesis. JNCI 56:1237–1242

    PubMed  Google Scholar 

  • Vogt TM, Selvin S, Billings JH (1979) Smoking cessation program: baseline carbon monoxide and serum thiocyanate levels as predictors of outcome. Am J Publ Health 69:1156–1159

    Article  CAS  Google Scholar 

  • Wald NJ, Boreham J, Bailey A, Ritchie C, Haddow JE, Knight G (1984) Urinary cotinine as marker for breathing other people’s tobacco smoke. Lancet 1:230–231

    Article  PubMed  CAS  Google Scholar 

  • Wynder EL, Graham EA (1950) Tobacco smoking as a possible etiological factor in bronchiogenic carcinoma. A study of six hundred and eighty-four proven cases. JAMA 143:329–336

    CAS  Google Scholar 

  • Wynder EL, Hoffmann D (1961) Present status of laboratory studies on tobacco carcinogenesis. Acta Pathol Microbiol Scand 52:110–132

    Google Scholar 

  • Wynder EL, Hoffmann D (1967) Tobacco and tobacco smoke. Studies in experimental carcinogenesis. Academic, New York

    Google Scholar 

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Authors
  1. D. Hoffmann
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  2. E. L. Wynder
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  3. S. S. Hecht
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  4. K. D. Brunnemann
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  5. E. J. La Voie
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  6. N. J. Haley
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Editor information

Editors and Affiliations

  1. Institut für Experimentelle Pathologie, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D-6900, Heidelberg, Germany

    Peter Bannasch

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© 1987 Springer-Verlag Berlin Heidelberg

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Hoffmann, D., Wynder, E.L., Hecht, S.S., Brunnemann, K.D., La Voie, E.J., Haley, N.J. (1987). Chemical Carcinogens in Tobacco. In: Bannasch, P. (eds) Cancer Risks. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71843-4_9

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  • DOI: https://doi.org/10.1007/978-3-642-71843-4_9

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-17465-3

  • Online ISBN: 978-3-642-71843-4

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