The Development of Intracerebral Blood Vessels Interacts With Astrocyte Development and Neuron Positioning in the Rat Neocortex

  • J. R. Wolff
Part of the NATO ASI Series book series (volume 5)


The nervous system of vertebrates and invertebrates contains neuroglial cells which completely separate neurons from the meninges. This “membrana limitans gliae” (Held, 1909) expands considerably where blood vessels enter the nervous tissue (Table 1). It is, therefore, not surprising that, in vertebrates, the number of non-radial or astrocyte-like glial cells increases with the expansion of intracerebral vascularization, while the number of radial or ependymal glial cells decreases (Sarnat et al., 1973). The correlation, however, is not absolute. Some non-radial glial cells occur in the absence of intracerebral vascularization (e.g., in the avascular spinal cord of Amphioxus; Bone 1960) and radial or ependymal glial cells (“Tanycytes”; Horstmann, 1954) can also form perivascular sheaths (e.g., Muller cells in vascularized retina). The data surveyed here may explain this lack of absolute correlation.


Glial Cell Basal Lamina Radial Glial Cell Vascular Wall Cell Neuron Position 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • J. R. Wolff
    • 1
    • 2
  1. 1.Department of AnatomyUniversity of GöttingenFederal Republic of Germany
  2. 2.Institute for Advanced Study BerlinFederal Republic of Germany

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