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The Role of Basal Lamina in Axon Regeneration

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Mesenchymal-Epithelial Interactions in Neural Development

Part of the book series: NATO ASI Series ((ASIH,volume 5))

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Abstract

Normal and acellular peripheral nerves of adult rats have been anastomosed to the optic nerves, disc and retina. At 30 days post lesion, axons regenerated into normal PN grafts but none grew into acellular PN grafts. Similarly, central axons did not regenerate into muscle or optic nerve grafts. Treatment of a PN graft with a mitotic arrest agent (mitomycin C) markedly reduced the number of fibres regenerating therein. No regenerating optic fibres were found in muscle grafts or in acellular optic nerve grafts. The results show that central axons grow only into Schwann cell populated grafts and not into either acellular PN, muscle or optic nerves even in the presence of a laminin rich basal lamina. These findings do not support the contention that laminin per se is neurotrophic in vivo but, instead, suggest that central axons regenerate into PN because Schwann cells elaborate a chemotactic factor which attracts central axons into the basal lamina tubes of the PN. It is not clear if the substrate for growth of axons within the basal lamina tubes is the laminin rich lamina lucida or the plasmalemma of the Schwann cell.

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Authors and Affiliations

  1. Anatomy Department, Guy’s Hospital Medical School, London, Great Britain

    M. Berry, S. M. Hall, E. L. Rees & P. Yiu

  2. Anatomy Department, University of Kiel, Kiel, Federal Republic of Germany

    J. Sievers

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  1. M. Berry
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  2. S. M. Hall
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  3. E. L. Rees
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  4. P. Yiu
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Editors and Affiliations

  1. Berlin Institute for Advanced Study, Zentrum Anatomie, Kreuzbergring 36, 3400, Göttingen, Germany

    Joachim R. Wolff

  2. Universität Göttingen, Zentrum Anatomie, Kreuzbergring 36, 3400, Göttingen, Germany

    Joachim R. Wolff

  3. Anatomiches Institut, Universität Kiel, Olshausentr. 40-60, Haus N10, 2300, Kiel, Germany

    Jobst Sievers

  4. Department of Anatomy, Guy’s Hospital Medical School, London, SE1 9RT, England

    Martin Berry

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© 1988 Springer-Verlag Berlin

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Berry, M., Hall, S.M., Rees, E.L., Yiu, P., Sievers, J. (1988). The Role of Basal Lamina in Axon Regeneration. In: Wolff, J.R., Sievers, J., Berry, M. (eds) Mesenchymal-Epithelial Interactions in Neural Development. NATO ASI Series, vol 5. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71837-3_28

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