Abstract
The survival and development of neurons is regulated by epigenetic factors (for review see Thoenen and Edgar, 1985). For example, the protein, Nerve Growth Factor (NGF), has been demonstrated to play a role in the nervous system: both peripheral sympathetic and sensory neurons derived from the neural crest need NGF for survival during development, and for maintenance during adulthood (see Thoenen and Edgar, 1985). Furthermore, it now seems that NGF plays a trophic role in the maintenance of magnocellular, cholinergic neurons of the central nervous system (Otten et al., 1985). The role of NGF in vivo is also reflected by the necessity for its presence for the survival of NGF-responsive neurons in culture (Thoenen and Edgar, 1985). Recently, it has become apparent that a variety of neurons that do not respond to NGF require other soluble trophic factors if they are to survive in vitro (see Barde et al., 1983). Two putative trophic molecules have been isolated by virtue of their ability to support neuronal survival in culture (Barde et al., 1982; Barbin et al., 1984). The role of these factors in vivo remains to be determined.
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© 1988 Springer-Verlag Berlin
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Edgar, D., Nurcombe, V., Dohrmann, U. (1988). Substrates Influencing the Survival and Development of Neural Cells in Vitro. In: Wolff, J.R., Sievers, J., Berry, M. (eds) Mesenchymal-Epithelial Interactions in Neural Development. NATO ASI Series, vol 5. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71837-3_26
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DOI: https://doi.org/10.1007/978-3-642-71837-3_26
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