Hormonal Regulation of Epithelial Morphogenesis, Growth and Cytodifferentiation in Fetal and Adult Urogenital Tracts: Roles of Mesenchymal-Epithelial Interactions

  • G. R. Cunha
  • R. M. Bigsby
  • A. A. Donjacour
  • P. S. Cooke
Part of the NATO ASI Series book series (volume 5)


The importance of mesenchymal-epithelial interactions for normal development is well established for a variety of structures and organs within the integumental, skeletal, gastro-intestinal, and neural systems (Kratochwil, 1972; Bernfield et al., 1973; Deuchar, 1975; Sengel, 1976; Saxen et al., 1976; Wessells, 1977; Fallon, 1983). Likewise, in the urogenital tract epithelial morphogenesis, growth, cytodifferentiation and function are induced and specified regionally by mesenchyme (Cunha, 1976a; Cunha et al., 1980a, 1983a). A special feature of the genital tract is that sex steroids and their analogs have profound developmental effects (Takasugi, 1976; McLachlan et al., 1980; Newbold and McLachlan, 1985; Bern and Talamantes, 1981; Clark and McCormack, 1977, 1980; Forsberg and Kalland, 1981; Taguchi and Nishizuka, 1985; Burns, 1961). These hormones may act in part by affecting mesenchymal-epithelial interactions in developing accessory sexual organs; such hormonal regulation provides unique opportunities for detailed analyses of the mechanism and control of these tissue interactions.


Androgen Receptor Mouse Mammary Gland Luminal Epithelium Uterine Epithelium Tissue Interaction 
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Copyright information

© Springer-Verlag Berlin Hedelberg 1987

Authors and Affiliations

  • G. R. Cunha
    • 1
    • 2
  • R. M. Bigsby
    • 2
  • A. A. Donjacour
    • 2
  • P. S. Cooke
    • 2
  1. 1.Cancer Research LaboratoryUniversity of CaliforniaBerkeleyUSA
  2. 2.Department of AnatomyUniversity of CaliforniaSan FranciscoUSA

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