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Hormonal Regulation of Epithelial Morphogenesis, Growth and Cytodifferentiation in Fetal and Adult Urogenital Tracts: Roles of Mesenchymal-Epithelial Interactions

  • G. R. Cunha
  • R. M. Bigsby
  • A. A. Donjacour
  • P. S. Cooke
Part of the NATO ASI Series book series (volume 5)

Abstract

The importance of mesenchymal-epithelial interactions for normal development is well established for a variety of structures and organs within the integumental, skeletal, gastro-intestinal, and neural systems (Kratochwil, 1972; Bernfield et al., 1973; Deuchar, 1975; Sengel, 1976; Saxen et al., 1976; Wessells, 1977; Fallon, 1983). Likewise, in the urogenital tract epithelial morphogenesis, growth, cytodifferentiation and function are induced and specified regionally by mesenchyme (Cunha, 1976a; Cunha et al., 1980a, 1983a). A special feature of the genital tract is that sex steroids and their analogs have profound developmental effects (Takasugi, 1976; McLachlan et al., 1980; Newbold and McLachlan, 1985; Bern and Talamantes, 1981; Clark and McCormack, 1977, 1980; Forsberg and Kalland, 1981; Taguchi and Nishizuka, 1985; Burns, 1961). These hormones may act in part by affecting mesenchymal-epithelial interactions in developing accessory sexual organs; such hormonal regulation provides unique opportunities for detailed analyses of the mechanism and control of these tissue interactions.

Keywords

Androgen Receptor Mouse Mammary Gland Luminal Epithelium Uterine Epithelium Tissue Interaction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Hedelberg 1987

Authors and Affiliations

  • G. R. Cunha
    • 1
    • 2
  • R. M. Bigsby
    • 2
  • A. A. Donjacour
    • 2
  • P. S. Cooke
    • 2
  1. 1.Cancer Research LaboratoryUniversity of CaliforniaBerkeleyUSA
  2. 2.Department of AnatomyUniversity of CaliforniaSan FranciscoUSA

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