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Fibroblast Growth Factor: Molecular and Biological Properties

  • Conference paper
Mesenchymal-Epithelial Interactions in Neural Development

Part of the book series: NATO ASI Series ((ASIH,volume 5))

Abstract

Many aspects of gene replication and expression have been solved by modern molecular biology and the study of viruses, bacteria and yeasts. The fundamental problem of cell proliferation and differentiation in eukaryotic cells still remains in most parts unresolved. The recently developed field of growth factors could provide answers at least in part as to the nature of the factors involved in cell proliferation and differentiation in developing organisms. In the following review we outline our present knowledge on one specific growth factor, Fibroblast growth factor (FGF). This factor which exists under two closely related forms (one basic, the other acidic) has been shown to trigger the proliferation and differentiation of a wide variety of mesoderm and neuroectoderm derived cells. Its mode of action could be intimately linked to that of extracellular matrix (ECM), which is known to regulate cell proliferation and gene expression, as well as morphogenetic tissue interactions.

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  1. Cancer Research Institute, University of California, Medical Center, San Francisco, CA, USA

    D. Gospodarowicz & G. Neufeld

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  1. D. Gospodarowicz
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  2. G. Neufeld
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  1. Berlin Institute for Advanced Study, Zentrum Anatomie, Kreuzbergring 36, 3400, Göttingen, Germany

    Joachim R. Wolff

  2. Universität Göttingen, Zentrum Anatomie, Kreuzbergring 36, 3400, Göttingen, Germany

    Joachim R. Wolff

  3. Anatomiches Institut, Universität Kiel, Olshausentr. 40-60, Haus N10, 2300, Kiel, Germany

    Jobst Sievers

  4. Department of Anatomy, Guy’s Hospital Medical School, London, SE1 9RT, England

    Martin Berry

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Gospodarowicz, D., Neufeld, G. (1987). Fibroblast Growth Factor: Molecular and Biological Properties. In: Wolff, J.R., Sievers, J., Berry, M. (eds) Mesenchymal-Epithelial Interactions in Neural Development. NATO ASI Series, vol 5. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71837-3_16

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