Influence of the Notochord on the Morphogenesis of the Neural Tube

  • H. W. M. van Straaten
  • J. Drukker
Part of the NATO ASI Series book series (volume 5)


In embryogenesis a well known phenomenon of induction is the determination of the neural plate as a result of contact between notochordal tissue and ectoderm (Jacobson, 1978). The factors involved in subsequent determination and morphogenesis of the neural tube are less well understood; influences emanating from the mesoderm, ectoderm and notochord together with intrinsic factors are held responsible for this development. Based on the results of isolation and of experimental rotation of the rhombencephalic neural plate in amphibians, Källen (1965) summarized that the alar and basal parts of the neural tube are already determined at the stage of the neural plate, and that there is good evidence for the assumption that many later processes of neural differentiation are already determined at the neural plate stage as well. Similar experiments in chick embryos of 2 days (neural tube just closed) did not lead to a uniform conclusion, which is likely to be caused by differences in experimental procedures (Steding, 1962; Jacob et al.; 1976; Martin, 1977).


Neural Tube Chick Embryo Neural Crest Cell Matrix Cell Neural Plate 
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  1. Bergquist, H. (1959) Experiments on the overgrowth phenomenon in the brain of chick embryos. Anat. Anz. 106: 429–441.Google Scholar
  2. Bernfield, M.R., S.D. Banerjee, J.E. Koda, and A.C. Rapraeger (1984) Remodelling of the basement membrane as a mechanism of morphogenetic tissue interaction. In Role of Extracellular Matrix in Development, R. Trelstad, ed., pp. 545–572. Alan R. Liss, New York.Google Scholar
  3. Burda, D.J. (1968) Studies on the experimental induction of overgrowth in chick embryos. Anat. Ree. 161: 419–425.CrossRefGoogle Scholar
  4. Cajal, S. Ramon y (1960) Studies on Vertebrate Neurogenesis. Translated by L. Guth. Charles C. Thomas, Publisher.Google Scholar
  5. Cheney, C.M., and J.W. Lash (1978) Chick somites: Heterogeneity in their response to notochord. J. Cell Biol. 79: 21a.Google Scholar
  6. Corliss, C.E., and G.G. Robertson (1963) The pattern of mitotic density in the early chick neural epithelium. J. Exp. Zool. 153: 125–140.PubMedCrossRefGoogle Scholar
  7. Fuyita, S. (1963) The matrix cell and cytogenesis in the developing central nervous system. J. Comp. Neurol. 120: 37–42.CrossRefGoogle Scholar
  8. Fuyita, S. (1964) Analysis of neuron differentiation in the central nervous system by tri- tiated thymidine autoradiography. J. Comp. Neurol. 122: 311–327.CrossRefGoogle Scholar
  9. Grabowski, C.T. (1956) The effects of excision of Hensen’s node on the early development of the chick embryo. J. Exp. Zool. 133: 301–343.CrossRefGoogle Scholar
  10. Hamburger, V. (1948) The mitotic pattern in the spinal cord of the chick embryo in relation to histogenetic processes. J. Comp. Neurol. 88: 221–284.PubMedCrossRefGoogle Scholar
  11. Hamburger, V., and H.L. Hamilton (1951) A seriers of normal stages in the development of the chick embryo. J. Morphol. 88: 49–92.CrossRefGoogle Scholar
  12. Hamburger, V. (1980) Trophic interactions in neurogenesis: A personal historical account. Ann. Rev. Neurose. 3: 269–278.CrossRefGoogle Scholar
  13. Hollyday, M., and V. Hamburger (1977) An autoradiographic study on the formation of the lateral motor column in the chick embryo. Brain Res. 132: 197–208.PubMedCrossRefGoogle Scholar
  14. Jacob, H.J., B. Christ, M. Jacob, and P. Ahlström (1976) Differenzierung des Neurairohres. Experimentelle Untersuchungen an Hühner- und Wachtelembryonen. Acta Anat. 94: 204–220.PubMedCrossRefGoogle Scholar
  15. Jacob, M., H.J. Jacob, and B. Christ (1975) Die frühe Differenzierung des chordanahen Bindegewebes. Raster- und transmissionselektronenmikroscopische Untersuchungen an Hühnerembryonen. Experientia 31: 1083–1086.PubMedCrossRefGoogle Scholar
  16. Jacobson, M. (1978) Developmental Neurobiology. 2nd ed. Plenum Press, New York.Google Scholar
  17. Källen, B. (1965) Early morphogenesis and pattern formation in the central nervous system. In Organogenesis, R. de Haan and H. Ursprung, eds., pp. 107–128. Holt, Rhinehart and Winston, New York.Google Scholar
  18. Kanemitsu, A. (1977) Development of spinal motor neurons. Adv. Neurol. Sei. 21: 204–217.Google Scholar
  19. Keynes, J., and C.D. Stern (1984) Segmentation in the vertebrate nervous system. Nature 310: 786–789.PubMedCrossRefGoogle Scholar
  20. Kitchin, I. (1949) The effects of notochordectomy in Amblystoma mexicanum. J. Exp. Zool. 112: 393–415.PubMedCrossRefGoogle Scholar
  21. Landmesser, L.T. (1980) The generation of neuromuscular specificity. Ann. Rev. Neuro- sci. 3: 279–302.CrossRefGoogle Scholar
  22. Limborgh, J. van (1956) The influence of adjacent mesodermal structures upon the shape of the neural tube and plate in bird embryos. Acta Morph. Neerl.-Scand. 1: 155–166.Google Scholar
  23. Lyser, K.M. (1964) Early differentiation of motor neuroblasts in the chick embryo as studied by electron microscopy. I. General aspects. Dev. Biol. 10: 433–466.PubMedCrossRefGoogle Scholar
  24. Martin, A.H. (1971) Mitotic patterns in the neural tube of the chick after unilateral removal of 1-J somites. Acta Embryol. Exp.: 9–16.Google Scholar
  25. Martin, A.H. (1977) Neural tube - somite interaction, effect of neural tube reversal upon neuron development. Acta Embryol. Exp. 3: 305–313.Google Scholar
  26. Miki, A., Y. Atoji, and H. Mizoguti (1981a) The relationship between the proliferating ability and acetylcholinesterase activity of the neural tube cells in early chick embryos. Acta Histochem. Cytochem. 14: 461–475.CrossRefGoogle Scholar
  27. Miki, S., Y. Atoji, and H. Mizoguti (1981b) Time of origin of the neuroblasts in the neural tube of the chick embryo determined by histochemical observation of acetylcholinesterase activity. Acta Histochem. Cytochem. 14: 641–653.CrossRefGoogle Scholar
  28. Mitolo, V. (1967) Quantitative data on the mitotic activity in the brachial and thoracic segments of the chick embryo neural tube from the 4th to the 8th day. Acta Embryol. Exp. 10: 62–74.Google Scholar
  29. Newgreen, D. (1982) The role of the extracellular matrix in the control of neural crest cell migration. In Extracellular Matrix, S. Hawkes and J.L. Wang, eds., pp. 141–145. Acad. Press, New York.Google Scholar
  30. Pehleman, F.-W., J. Sievers, and M. Berry (1985) Meningeal cells are involved in foliation, lamination and neurogenesis of the cerbellum: Evidence from 6-hydroxy- dopamine-induced destruction of meningeal cells. Dev. Biol. 110: 136–146.CrossRefGoogle Scholar
  31. Pintar, J.E. (1978) Distribution and synthesis of glycosaminoglycans during quail neural crest morphogenesis. Dev. Biol. 67: 444–464.PubMedCrossRefGoogle Scholar
  32. Rogers, S.L., K.J. Edson, P.C. Letourneau, and S.C. McLoon (1986) Distribution of lami- nin in the developing peripheral nervous system of the chick. Dev. Biol. 113: 429–435.PubMedCrossRefGoogle Scholar
  33. Sievers, J., F.-W. Pehlemann, H.-G. Baumgarten, and M. Berry (1985) Selective destruction of meningeal cells by 6-hydroxydopamine: A tool to study Meningeal-neuroepithelial interaction in brain development. Dev. Biol. 110: 127–135.PubMedCrossRefGoogle Scholar
  34. Steding, G. (1962) Experimente zur Morphogenese des Rückenmarkes. Acta Anat. 49: 199–231.PubMedCrossRefGoogle Scholar
  35. Stern, C.D. (1984) Mini-review: Hyaluronidases in early embryonic development. Cell Biol. Intern. Reports 8: 703–717.CrossRefGoogle Scholar
  36. Straaten, H.W.M. van, F. Thors, E.L. Hoessels, J.W.M. Hekking, and J. Drukker (1985a) Effect of a notochordal implant on the early morphogenesis of the neural tube and neuroblasts. Histometrical and histological results. Dev. Biol. 110: 247–254.PubMedCrossRefGoogle Scholar
  37. Straaten, H.W.M. van, J.W.M. Hekking, F. Thors, E.L.J.M. Wiertz, and J. Drukker (1985b) Induction of an additional floor plate in the neural tube. Acta Morphol. Neerl.- Scand. 23: 91–97.PubMedGoogle Scholar
  38. Takaya, H. (1977) Types of neural tissue induced through the presumptive notochord of newt embryo. Differentiation 7: 187–192.PubMedCrossRefGoogle Scholar
  39. Thiery, J.P., A. Delouvée, M. Grumet, and G.M. Edelman (1985) Initial appearance and regional distribution of the neuron-glia cell adhesion molecule in the chick embryo. J. Cell Biol. 100: 442–456.PubMedCrossRefGoogle Scholar
  40. Toole, B.P. (1981) Glycosaminoglycans in morphogenesis. In Cell Biology of Extracellular Matrix, E.D.Hay, ed., pp. 259–294. Plenum Press, New York.CrossRefGoogle Scholar
  41. Thors, F., E.M.J, de Kort, and R. Nieuwenhuys (1982) On the development of the spinal cord of the clawed frog, Xenopus laevis. 11 Experimental analysis of differentiation and migration. Anat. Embryol. 164: 443–454.Google Scholar
  42. Watterson, R.L., C. Goodheart, and G. Lindberg (1955) The influence of adjacent structures upon the shape of the neural tube and neural plate of chick embryos. Anat. Rec. 122: 539–559.PubMedCrossRefGoogle Scholar
  43. Watterson, R.L. (1965) Structure and mitotic behavior of the early neural tube. In Or¬ganogenesis, R.L. de Haan and H. Ursprung, eds., pp. 129–159. Holt, Rhinehart and Winston, New York and Chicago.Google Scholar
  44. Weiss, P. (1955) Nervous system. In Analysis of Development, B.H. Willier, P. Weiss, and V. Hamburger, eds., pp. 346–401. Saunders, Philadelphia.Google Scholar
  45. Wiertz-Hoessels, E.L.M.J., K. Hara, J.W.M. Hekking, H.W.M. van Straaten, F. Thors, and J. Drukker (1986) Differentiation of gut entoderm in dependence of the notochord, submitted for publication.Google Scholar
  46. Youn, B.W., and G.M. Malacinsky (1981) Axial structure development in ultraviolet- irradiated (notochord-defective) amphibian embryos. Dev. Biol. 83: 339–352.PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1987

Authors and Affiliations

  • H. W. M. van Straaten
    • 1
  • J. Drukker
    • 1
  1. 1.Department of Anatomy and EmbryologyNational University of LimburgMaastrichtNetherlands

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