Abstract
It is now known that proteoglycans are components not only of extracellular matrices but are also found associated with the plasma membrane. Cell surface proteoglycans that have been described and characterized can be relatively small molecules (140kd, Carlstedt et al., 1983) or considerably larger (~400 kd, Woods et al., 1985) and contain mainly chondroitin, dermatan and/or heparan sulfate chains on a polypeptide chain which may be either peripherally or integrally associated with the cell membrane (Hook et al., 1984; c.f. Bernfield, this volume). These molecules contrast with extracellular matrix proteoglycans both in their location and size, since all matrix proteoglycans are extremely large (>500kd) (Caplan, 1984; Anderson and Fambrough, 1983; Hassell et al., 1985). We have studied the function of both cell surface and extracellular matrix proteoglycans in peripheral nerve tissues by the use of an inhibitor of proteoglycan biosynthesis, 4-methyl umbelliferyl-β-D-xyloside.
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Ratner, N., Eldridge, C., Bunge, R., Glaser, L. (1987). Effects of an Inhibitor of Proteoglycan Biosynthesis on Neuron-Induced Schwann Cell Proliferation and Basal Lamina Formation By Schwann Cells. In: Wolff, J.R., Sievers, J., Berry, M. (eds) Mesenchymal-Epithelial Interactions in Neural Development. NATO ASI Series, vol 5. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71837-3_11
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DOI: https://doi.org/10.1007/978-3-642-71837-3_11
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