Radioimmunoassay of Platelet Proteins

  • D. S. Pepper
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 82)


The platelets, formed by fragmentation from the megakaryocytes in the bone marrow, circulate in the blood and play a significant role in normal haemostasis as well as in pathological processes such as thrombosis, atherosclerosis, inflammation and immune rejection. Within the platelet are secretory storage vesicles of both dense and a granules containing respectively lower and higher molecular weight species. The contents of the a granules are largely proteins and include not only the familiar plasma proteins such as albumin and fibrinogen, but also a large proportion of unique proteins that have been referred to as platelet-specific granule proteins. Since normal plasma contains only low levels of these latter proteins, their assay measurement in plasma ex vivo constitutes a valuable method of measuring platelet activation and secretion as it occurs in vivo.


Platelet Activation Human Platelet Anti Platelet Drug Platelet Protein Platelet Release 
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© Springer-Verlag Berlin Heidelberg 1987

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  • D. S. Pepper

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