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Radioimmunoassay of Platelet Proteins

  • Chapter
Radioimmunoassay in Basic and Clinical Pharmacology

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 82))

Abstract

The platelets, formed by fragmentation from the megakaryocytes in the bone marrow, circulate in the blood and play a significant role in normal haemostasis as well as in pathological processes such as thrombosis, atherosclerosis, inflammation and immune rejection. Within the platelet are secretory storage vesicles of both dense and a granules containing respectively lower and higher molecular weight species. The contents of the a granules are largely proteins and include not only the familiar plasma proteins such as albumin and fibrinogen, but also a large proportion of unique proteins that have been referred to as platelet-specific granule proteins. Since normal plasma contains only low levels of these latter proteins, their assay measurement in plasma ex vivo constitutes a valuable method of measuring platelet activation and secretion as it occurs in vivo.

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Authors
  1. D. S. Pepper
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Editors and Affiliations

  1. Institute of Pharmacology, Catholic University of the Sacred Heart, Largo Francesco Vito, 1, I-00168, Rome, Italy

    Carlo Patrono (Professor of Molecular Pharmacology) (Professor of Molecular Pharmacology)

  2. Institute of Pharmacology and Toxicology, Ruhr-University Bochum Im Lottental, P.O. Box 102148, D-4630, Bochum 1, Germany

    Bernhard A. Peskar (Professor of Pharmacology and Toxicology) (Professor of Pharmacology and Toxicology)

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© 1987 Springer-Verlag Berlin Heidelberg

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Pepper, D.S. (1987). Radioimmunoassay of Platelet Proteins. In: Patrono, C., Peskar, B.A. (eds) Radioimmunoassay in Basic and Clinical Pharmacology. Handbook of Experimental Pharmacology, vol 82. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71809-0_21

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  • DOI: https://doi.org/10.1007/978-3-642-71809-0_21

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-71811-3

  • Online ISBN: 978-3-642-71809-0

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