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Basic Principles of Antigen-Antibody Interaction

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Radioimmunoassay in Basic and Clinical Pharmacology

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 82))

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Abstract

The immune system may be viewed as the locus of a multitude of molecular interactions involving a limited number of genetically determined structures. Most of these structures act as membrane receptors (i.e., communication organs of cells) or as secreted factors. These are called antibodies (Ab), T cell receptors, or class I and II molecules coded for in the major histocompatibility complex (MHC).

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References

  • Celada F, Strom R (1972) Antibody-induced conformational changes in proteins. Q Rev Biophys 5: 395–425

    Article  PubMed  CAS  Google Scholar 

  • Celada F, Macario AJL, Conway De Macario E (1973) Enzyme activation by antibodies: a method to determine the binding constant of the activating antibody towards one determinant of E. Coli ß-D-galactosidase. Immunochemistry 10: 797–804

    Article  CAS  Google Scholar 

  • Celada F, Schumaker VN, Sercarz EE (eds) (1983) Protein conformation as an immunological signal. Plenum, New York

    Google Scholar 

  • Crumpton MJ (1966) Conformational changes in sperm whale metmyoglobin due to combination with antibodies to myoglobin. Biochem J 100: 227–234

    Google Scholar 

  • Davis MM, Kim SK, Hood L (1980) Immunoglobulin class switching: developmentally regulated DNA rearrangements during differentiation. Cell 22: 1–2

    Article  PubMed  CAS  Google Scholar 

  • Eisen HN (1980) Immunology, 2nd edn., Harper and Row, Hagerstown

    Google Scholar 

  • Gerhart P, Johnson ND, Douglas R, Hood L (1981) IgG antibodies to phosphorylcholine exhibit more diversity than their IgM counterparts. Nature. 291: 29–34

    Article  Google Scholar 

  • Givol D (1973) Structural analysis of the antibody combining site. Contemp Top Mol Immunol 2: 27–45

    PubMed  CAS  Google Scholar 

  • Jerne NK (1960) Immunological speculations. Annu Rev Microbiol. 14: 341–358

    Article  PubMed  CAS  Google Scholar 

  • Jerne NK (1974) Towards a network theory of the immune system. Ann Immunol. 125c: 373

    CAS  Google Scholar 

  • Kabat EA (1966) The nature of an antigenic determinant. J Immunol. 97: 1–11

    PubMed  CAS  Google Scholar 

  • Kabat EA (1968) Structural concepts in immunology and immunochemistry, 2nd edn. Holt, Rinehart, and Winston, New York

    Google Scholar 

  • Landsteiner K (1936) The specificity of serological reactions, 2nd edn. Harvard University Press, Cambridge

    Google Scholar 

  • Leder P (1982) The genetics of antibody diversity. Sci Am. 246: 102–113

    Article  PubMed  CAS  Google Scholar 

  • Metzger H (1978) The effect of antigen on antibodies: recent studies. Contemp Top Mol Immunol 8: 119–152

    Google Scholar 

  • Mitchison NA (1971 a) The carrier effect in the secondary response to hapten-protein con-jugates. I. Measurement of the effect with transferred cells and objections to the local environment hypothesis. Eur J Immunol. 1: 10–17

    Google Scholar 

  • Mitchison NA (1971 b) The carrier effect in the secondary response to hapten-protein conjugates. II. Cellular cooperation. Eur J Immunol. 1: 18–25

    Google Scholar 

  • Natvig JB, Kunkel HG (1973) Human immunoglobulins: classes, subclasses, genetic variants and idiotypes. Adv Immunol. 16: 1–59

    Article  PubMed  CAS  Google Scholar 

  • Poljak RJ (1975) X-ray diffraction studies of immunoglobulins. Adv Immunol. 21: 1–32

    Article  PubMed  CAS  Google Scholar 

  • Rogers J, Early P, Carter C, Calame K, Bond M (1980) Two mRNAs with different 3’ ends encode membrane-bound and secreted form of immunoglobulinµchain.Cell. 20: 303–312

    Article  PubMed  CAS  Google Scholar 

  • Rotman B, Celada F (1968) Antibody-mediated activation of a defective ß-D-galactosidase extracted from an Escherichia Coli mutant. Proc Natl Acad Sci USA. 60: 660–667

    Article  PubMed  CAS  Google Scholar 

  • Schechter B, Schechter I, Sela M (1970) Antibody combining site to a series of peptide determinants of increasing size and defined structure. J Biol Chem. 245: 1438–1447

    PubMed  CAS  Google Scholar 

  • Schechter B, Conway Jabobs A, Sela M (1971) Conformational changes in a synthetic antigen induced by specific antibodies. Eur J Biochem. 20: 321–324

    Article  PubMed  CAS  Google Scholar 

  • Sela M (1969) Antigenicity: some molecular aspects. Science. 166: 1365–1374

    Article  PubMed  CAS  Google Scholar 

  • Sela M, Schechter B, Schechter I, Borek M (1967) Antibodies to sequential and conformational determinants. Cold Spring Harb Symp Quant Biol. 32: 537–539

    CAS  Google Scholar 

  • Sips R (1949) On the structure of a catalyst’s surface. J Chem Phys. 16: 490

    Article  Google Scholar 

  • Velick SF, Parker CW, Eisen HN (1960) Excitation energy transfer and the quantitative study of the antibody hapten reaction. Proc Natl Acad Sci USA. 46: 1470–1482

    Article  PubMed  CAS  Google Scholar 

  • Weir DM (1976) Handbook of experimental immunology, 3rd edn. Blackwell Scientific, London

    Google Scholar 

  • Wu TTE, Kabat EA (1970) An analysis of the sequences of the variable regions of Bence Jones proteins and myeloma light chain and their implications for antibody complementarity. J Exp Med. 132: 211–250

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. F. Celada
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Editors and Affiliations

  1. Institute of Pharmacology, Catholic University of the Sacred Heart, Largo Francesco Vito, 1, I-00168, Rome, Italy

    Carlo Patrono (Professor of Molecular Pharmacology) (Professor of Molecular Pharmacology)

  2. Institute of Pharmacology and Toxicology, Ruhr-University Bochum Im Lottental, P.O. Box 102148, D-4630, Bochum 1, Germany

    Bernhard A. Peskar (Professor of Pharmacology and Toxicology) (Professor of Pharmacology and Toxicology)

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© 1987 Springer-Verlag Berlin Heidelberg

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Celada, F. (1987). Basic Principles of Antigen-Antibody Interaction. In: Patrono, C., Peskar, B.A. (eds) Radioimmunoassay in Basic and Clinical Pharmacology. Handbook of Experimental Pharmacology, vol 82. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71809-0_2

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  • DOI: https://doi.org/10.1007/978-3-642-71809-0_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-71811-3

  • Online ISBN: 978-3-642-71809-0

  • eBook Packages: Springer Book Archive

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